Cryo-EM structure of mammalian RNA polymerase II in complex with human RPAP2

RNA polymerase II needs to be imported into the nucleus to perform transcription. Fianu et al. show that RPAP2 binds to Pol II and enters the nucleus with it, before releasing it to perform transcription and returning to the cytoplasm.

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Auteurs principaux:	Isaac Fianu, Christian Dienemann, Shintaro Aibara, Sandra Schilbach, Patrick Cramer
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Biology (General) QH301-705.5
Accès en ligne:	https://doaj.org/article/5f61211da5b646c69952d51767e5f8fe
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id	oai:doaj.org-article:5f61211da5b646c69952d51767e5f8fe
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spelling	oai:doaj.org-article:5f61211da5b646c69952d51767e5f8fe2021-12-02T15:45:15ZCryo-EM structure of mammalian RNA polymerase II in complex with human RPAP210.1038/s42003-021-02088-z2399-3642https://doaj.org/article/5f61211da5b646c69952d51767e5f8fe2021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02088-zhttps://doaj.org/toc/2399-3642RNA polymerase II needs to be imported into the nucleus to perform transcription. Fianu et al. show that RPAP2 binds to Pol II and enters the nucleus with it, before releasing it to perform transcription and returning to the cytoplasm.Isaac FianuChristian DienemannShintaro AibaraSandra SchilbachPatrick CramerNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Isaac Fianu Christian Dienemann Shintaro Aibara Sandra Schilbach Patrick Cramer Cryo-EM structure of mammalian RNA polymerase II in complex with human RPAP2
description	RNA polymerase II needs to be imported into the nucleus to perform transcription. Fianu et al. show that RPAP2 binds to Pol II and enters the nucleus with it, before releasing it to perform transcription and returning to the cytoplasm.
format	article
author	Isaac Fianu Christian Dienemann Shintaro Aibara Sandra Schilbach Patrick Cramer
author_facet	Isaac Fianu Christian Dienemann Shintaro Aibara Sandra Schilbach Patrick Cramer
author_sort	Isaac Fianu
title	Cryo-EM structure of mammalian RNA polymerase II in complex with human RPAP2
title_short	Cryo-EM structure of mammalian RNA polymerase II in complex with human RPAP2
title_full	Cryo-EM structure of mammalian RNA polymerase II in complex with human RPAP2
title_fullStr	Cryo-EM structure of mammalian RNA polymerase II in complex with human RPAP2
title_full_unstemmed	Cryo-EM structure of mammalian RNA polymerase II in complex with human RPAP2
title_sort	cryo-em structure of mammalian rna polymerase ii in complex with human rpap2
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5f61211da5b646c69952d51767e5f8fe
work_keys_str_mv	AT isaacfianu cryoemstructureofmammalianrnapolymeraseiiincomplexwithhumanrpap2 AT christiandienemann cryoemstructureofmammalianrnapolymeraseiiincomplexwithhumanrpap2 AT shintaroaibara cryoemstructureofmammalianrnapolymeraseiiincomplexwithhumanrpap2 AT sandraschilbach cryoemstructureofmammalianrnapolymeraseiiincomplexwithhumanrpap2 AT patrickcramer cryoemstructureofmammalianrnapolymeraseiiincomplexwithhumanrpap2
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Cryo-EM structure of mammalian RNA polymerase II in complex with human RPAP2

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