Approaching Neoadjuvant Therapy in the Management of Early-Stage Breast Cancer

Tara Hyder,1 Saveri Bhattacharya,2,* Kristine Gade,3,* Azadeh Nasrazadani,3 Adam M Brufsky3 1University of Pittsburgh Physicians, Pittsburgh, PA, USA; 2Department of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA; 3UPMC Hillman Cancer Center, Magee...

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Autores principales:	Hyder T, Bhattacharya S, Gade K, Nasrazadani A, Brufsky AM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	neoadjuvant chemotherapy neoadjuvant endocrine therapy pcr breast conserving surgery Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/5f635ff8701c42129f91df04a69b4463
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spelling	oai:doaj.org-article:5f635ff8701c42129f91df04a69b44632021-12-02T15:59:22ZApproaching Neoadjuvant Therapy in the Management of Early-Stage Breast Cancer1179-1314https://doaj.org/article/5f635ff8701c42129f91df04a69b44632021-03-01T00:00:00Zhttps://www.dovepress.com/approaching-neoadjuvant-therapy-in-the-management-of-early-stage-breas-peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Tara Hyder,1 Saveri Bhattacharya,2,* Kristine Gade,3,* Azadeh Nasrazadani,3 Adam M Brufsky3 1University of Pittsburgh Physicians, Pittsburgh, PA, USA; 2Department of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA; 3UPMC Hillman Cancer Center, Magee Women’s Hospital, Pittsburgh, PA, USA*These authors contributed equally to this workCorrespondence: Adam M BrufskyUPMC Hillman Cancer Center, Magee Women’s Hospital, Suite 4628, 300 Halket Street, Pittsburgh, PA, 15213, USAEmail brufskyam@upmc.eduAbstract: Neoadjuvant therapy is integral to the treatment of early-stage breast cancer. Goals of treatment include surgical downstaging of the tumor, rendering inoperable tumors resectable, and de-escalating axillary surgery in those with clinically positive nodes. Additionally, response to treatment provides important prognostic information regarding risk of recurrence and guides future adjuvant treatment. Although chemotherapy serves as the backbone of neoadjuvant treatment, an increased understanding of the tumor’s clinical course as well as its molecular and genetic make-up aids in individualizing treatment and developing novel agents. This review summarizes current clinical approaches and the future direction to the management of breast cancer patients in the neoadjuvant setting.Keywords: neoadjuvant chemotherapy, neoadjuvant endocrine therapy, pCR, breast-conserving surgeryHyder TBhattacharya SGade KNasrazadani ABrufsky AMDove Medical Pressarticleneoadjuvant chemotherapyneoadjuvant endocrine therapypcrbreast conserving surgeryNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 13, Pp 199-211 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neoadjuvant chemotherapy neoadjuvant endocrine therapy pcr breast conserving surgery Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	neoadjuvant chemotherapy neoadjuvant endocrine therapy pcr breast conserving surgery Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Hyder T Bhattacharya S Gade K Nasrazadani A Brufsky AM Approaching Neoadjuvant Therapy in the Management of Early-Stage Breast Cancer
description	Tara Hyder,1 Saveri Bhattacharya,2,* Kristine Gade,3,* Azadeh Nasrazadani,3 Adam M Brufsky3 1University of Pittsburgh Physicians, Pittsburgh, PA, USA; 2Department of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA; 3UPMC Hillman Cancer Center, Magee Women’s Hospital, Pittsburgh, PA, USA*These authors contributed equally to this workCorrespondence: Adam M BrufskyUPMC Hillman Cancer Center, Magee Women’s Hospital, Suite 4628, 300 Halket Street, Pittsburgh, PA, 15213, USAEmail brufskyam@upmc.eduAbstract: Neoadjuvant therapy is integral to the treatment of early-stage breast cancer. Goals of treatment include surgical downstaging of the tumor, rendering inoperable tumors resectable, and de-escalating axillary surgery in those with clinically positive nodes. Additionally, response to treatment provides important prognostic information regarding risk of recurrence and guides future adjuvant treatment. Although chemotherapy serves as the backbone of neoadjuvant treatment, an increased understanding of the tumor’s clinical course as well as its molecular and genetic make-up aids in individualizing treatment and developing novel agents. This review summarizes current clinical approaches and the future direction to the management of breast cancer patients in the neoadjuvant setting.Keywords: neoadjuvant chemotherapy, neoadjuvant endocrine therapy, pCR, breast-conserving surgery
format	article
author	Hyder T Bhattacharya S Gade K Nasrazadani A Brufsky AM
author_facet	Hyder T Bhattacharya S Gade K Nasrazadani A Brufsky AM
author_sort	Hyder T
title	Approaching Neoadjuvant Therapy in the Management of Early-Stage Breast Cancer
title_short	Approaching Neoadjuvant Therapy in the Management of Early-Stage Breast Cancer
title_full	Approaching Neoadjuvant Therapy in the Management of Early-Stage Breast Cancer
title_fullStr	Approaching Neoadjuvant Therapy in the Management of Early-Stage Breast Cancer
title_full_unstemmed	Approaching Neoadjuvant Therapy in the Management of Early-Stage Breast Cancer
title_sort	approaching neoadjuvant therapy in the management of early-stage breast cancer
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/5f635ff8701c42129f91df04a69b4463
work_keys_str_mv	AT hydert approachingneoadjuvanttherapyinthemanagementofearlystagebreastcancer AT bhattacharyas approachingneoadjuvanttherapyinthemanagementofearlystagebreastcancer AT gadek approachingneoadjuvanttherapyinthemanagementofearlystagebreastcancer AT nasrazadania approachingneoadjuvanttherapyinthemanagementofearlystagebreastcancer AT brufskyam approachingneoadjuvanttherapyinthemanagementofearlystagebreastcancer
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Approaching Neoadjuvant Therapy in the Management of Early-Stage Breast Cancer

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