Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase

The suppressor of cytokine signaling 2 (SOCS2) is a component of the Cullin5 E3 ubiquitin ligase complex. Here the authors provide insights into substrate recognition and specificity of SOCS2 by determining the crystal structures of the SOCS2-ElonginB-ElonginC in complex with phosphorylated peptides...

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Autores principales:	Wei-Wei Kung, Sarath Ramachandran, Nikolai Makukhin, Elvira Bruno, Alessio Ciulli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5f64f9c2c7dd475d9276013f7571de57
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spelling	oai:doaj.org-article:5f64f9c2c7dd475d9276013f7571de572021-12-02T17:02:14ZStructural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase10.1038/s41467-019-10190-42041-1723https://doaj.org/article/5f64f9c2c7dd475d9276013f7571de572019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10190-4https://doaj.org/toc/2041-1723The suppressor of cytokine signaling 2 (SOCS2) is a component of the Cullin5 E3 ubiquitin ligase complex. Here the authors provide insights into substrate recognition and specificity of SOCS2 by determining the crystal structures of the SOCS2-ElonginB-ElonginC in complex with phosphorylated peptides from two of its substrates the growth hormone receptor and erythropoietin receptor.Wei-Wei KungSarath RamachandranNikolai MakukhinElvira BrunoAlessio CiulliNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wei-Wei Kung Sarath Ramachandran Nikolai Makukhin Elvira Bruno Alessio Ciulli Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase
description	The suppressor of cytokine signaling 2 (SOCS2) is a component of the Cullin5 E3 ubiquitin ligase complex. Here the authors provide insights into substrate recognition and specificity of SOCS2 by determining the crystal structures of the SOCS2-ElonginB-ElonginC in complex with phosphorylated peptides from two of its substrates the growth hormone receptor and erythropoietin receptor.
format	article
author	Wei-Wei Kung Sarath Ramachandran Nikolai Makukhin Elvira Bruno Alessio Ciulli
author_facet	Wei-Wei Kung Sarath Ramachandran Nikolai Makukhin Elvira Bruno Alessio Ciulli
author_sort	Wei-Wei Kung
title	Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase
title_short	Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase
title_full	Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase
title_fullStr	Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase
title_full_unstemmed	Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase
title_sort	structural insights into substrate recognition by the socs2 e3 ubiquitin ligase
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/5f64f9c2c7dd475d9276013f7571de57
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Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase

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