Evaluation of the usefulness of saliva for mosaic loss of chromosome Y analysis

Abstract Mosaic loss of chromosome Y (mLOY) in leukocytes has attracted much attention as an emerging biomarker of aging and aging-related diseases. We evaluated the usefulness of saliva for mLOY analysis and showed that saliva-derived mLOY is significantly associated with aging and increased physic...

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Autores principales:	Tsuyoshi Hachiya, Takuro Kobayashi, Wataru Tsutae, Pamela Hui Peng Gan, Iri Sato Baran, Shigeo Horie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5f696ba12a9547d09eeb108bedab312c
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spelling	oai:doaj.org-article:5f696ba12a9547d09eeb108bedab312c2021-12-02T13:30:17ZEvaluation of the usefulness of saliva for mosaic loss of chromosome Y analysis10.1038/s41598-021-83308-82045-2322https://doaj.org/article/5f696ba12a9547d09eeb108bedab312c2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83308-8https://doaj.org/toc/2045-2322Abstract Mosaic loss of chromosome Y (mLOY) in leukocytes has attracted much attention as an emerging biomarker of aging and aging-related diseases. We evaluated the usefulness of saliva for mLOY analysis and showed that saliva-derived mLOY is significantly associated with aging and increased physical activity, but not with smoking. While these data support the robust association between saliva-derived mLOY and aging, caution is required when comparing data from saliva-derived and blood-derived mLOY.Tsuyoshi HachiyaTakuro KobayashiWataru TsutaePamela Hui Peng GanIri Sato BaranShigeo HorieNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tsuyoshi Hachiya Takuro Kobayashi Wataru Tsutae Pamela Hui Peng Gan Iri Sato Baran Shigeo Horie Evaluation of the usefulness of saliva for mosaic loss of chromosome Y analysis
description	Abstract Mosaic loss of chromosome Y (mLOY) in leukocytes has attracted much attention as an emerging biomarker of aging and aging-related diseases. We evaluated the usefulness of saliva for mLOY analysis and showed that saliva-derived mLOY is significantly associated with aging and increased physical activity, but not with smoking. While these data support the robust association between saliva-derived mLOY and aging, caution is required when comparing data from saliva-derived and blood-derived mLOY.
format	article
author	Tsuyoshi Hachiya Takuro Kobayashi Wataru Tsutae Pamela Hui Peng Gan Iri Sato Baran Shigeo Horie
author_facet	Tsuyoshi Hachiya Takuro Kobayashi Wataru Tsutae Pamela Hui Peng Gan Iri Sato Baran Shigeo Horie
author_sort	Tsuyoshi Hachiya
title	Evaluation of the usefulness of saliva for mosaic loss of chromosome Y analysis
title_short	Evaluation of the usefulness of saliva for mosaic loss of chromosome Y analysis
title_full	Evaluation of the usefulness of saliva for mosaic loss of chromosome Y analysis
title_fullStr	Evaluation of the usefulness of saliva for mosaic loss of chromosome Y analysis
title_full_unstemmed	Evaluation of the usefulness of saliva for mosaic loss of chromosome Y analysis
title_sort	evaluation of the usefulness of saliva for mosaic loss of chromosome y analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5f696ba12a9547d09eeb108bedab312c
work_keys_str_mv	AT tsuyoshihachiya evaluationoftheusefulnessofsalivaformosaiclossofchromosomeyanalysis AT takurokobayashi evaluationoftheusefulnessofsalivaformosaiclossofchromosomeyanalysis AT watarutsutae evaluationoftheusefulnessofsalivaformosaiclossofchromosomeyanalysis AT pamelahuipenggan evaluationoftheusefulnessofsalivaformosaiclossofchromosomeyanalysis AT irisatobaran evaluationoftheusefulnessofsalivaformosaiclossofchromosomeyanalysis AT shigeohorie evaluationoftheusefulnessofsalivaformosaiclossofchromosomeyanalysis
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Evaluation of the usefulness of saliva for mosaic loss of chromosome Y analysis

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