K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation

Receptor-interacting protein kinase 1 (RIPK1) is a critical regulator of cell death but its regulation is unclear. Here, the authors report that RIPK1 kinase activity is regulated by ubiquitination.

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Autores principales:	Yong Tang, Hailin Tu, Jie Zhang, Xueqiang Zhao, Yini Wang, Jun Qin, Xin Lin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5f6a89e4047e44afb3649cdadbb4c91f
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spelling	oai:doaj.org-article:5f6a89e4047e44afb3649cdadbb4c91f2021-12-02T17:01:37ZK63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation10.1038/s41467-019-12033-82041-1723https://doaj.org/article/5f6a89e4047e44afb3649cdadbb4c91f2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12033-8https://doaj.org/toc/2041-1723Receptor-interacting protein kinase 1 (RIPK1) is a critical regulator of cell death but its regulation is unclear. Here, the authors report that RIPK1 kinase activity is regulated by ubiquitination.Yong TangHailin TuJie ZhangXueqiang ZhaoYini WangJun QinXin LinNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yong Tang Hailin Tu Jie Zhang Xueqiang Zhao Yini Wang Jun Qin Xin Lin K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation
description	Receptor-interacting protein kinase 1 (RIPK1) is a critical regulator of cell death but its regulation is unclear. Here, the authors report that RIPK1 kinase activity is regulated by ubiquitination.
format	article
author	Yong Tang Hailin Tu Jie Zhang Xueqiang Zhao Yini Wang Jun Qin Xin Lin
author_facet	Yong Tang Hailin Tu Jie Zhang Xueqiang Zhao Yini Wang Jun Qin Xin Lin
author_sort	Yong Tang
title	K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation
title_short	K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation
title_full	K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation
title_fullStr	K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation
title_full_unstemmed	K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation
title_sort	k63-linked ubiquitination regulates ripk1 kinase activity to prevent cell death during embryogenesis and inflammation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/5f6a89e4047e44afb3649cdadbb4c91f
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K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation

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