K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation

Receptor-interacting protein kinase 1 (RIPK1) is a critical regulator of cell death but its regulation is unclear. Here, the authors report that RIPK1 kinase activity is regulated by ubiquitination.

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Detalles Bibliográficos
Autores principales: Yong Tang, Hailin Tu, Jie Zhang, Xueqiang Zhao, Yini Wang, Jun Qin, Xin Lin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/5f6a89e4047e44afb3649cdadbb4c91f
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