Tongue Strength Training Increases Daytime Upper Airway Stability in Rats
Hong Huang, Wenyang Li, Hongyu Jin, Lei Zhang, Zhijing Wei, Wei Wang Institute of Respiratory and Critical Care, The First Hospital of China Medical University, Shenyang, People’s Republic of ChinaCorrespondence: Wei WangInstitute of Respiratory and Critical Care, The First Hospital of China Medical...
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Dove Medical Press
2021
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oai:doaj.org-article:5f6e538c2fb8403fadfe4c5b6d969af32021-12-02T17:40:32ZTongue Strength Training Increases Daytime Upper Airway Stability in Rats1179-1608https://doaj.org/article/5f6e538c2fb8403fadfe4c5b6d969af32021-09-01T00:00:00Zhttps://www.dovepress.com/tongue-strength-training-increases-daytime-upper-airway-stability-in-r-peer-reviewed-fulltext-article-NSShttps://doaj.org/toc/1179-1608Hong Huang, Wenyang Li, Hongyu Jin, Lei Zhang, Zhijing Wei, Wei Wang Institute of Respiratory and Critical Care, The First Hospital of China Medical University, Shenyang, People’s Republic of ChinaCorrespondence: Wei WangInstitute of Respiratory and Critical Care, The First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, Liaoning, 110001, People’s Republic of ChinaTel +86 24 83282529Fax +86 2483282002Email wwbycmu@126.comPurpose: Tongue strength training (TST) has been shown to decrease the apnea-hypopnea index in some patients with obstructive sleep apnea (OSA). However, whether TST modulates the central regulation of genioglossus and influences the stability of the upper airway remains unknown. The purpose of this study was to dynamically assess the effect of TST on the upper airway.Methods: Sixteen adult male Sprague–Dawley rats were studied to explore the mechanism of TST improving the upper airway function. The rats were randomly assigned to the normal control (NC) and TST groups. The TST group underwent 8-week progressive resistance tongue exercise training. Transcranial magnetic stimulation (TMS) responses and EMG activities were consistently recorded for 2 h on days 0, 14, 28, and 56 of the experiments in both groups. Theoretical critical pressure (Pcrit) value was measured on days 0, 14, 28, and 56.Results: The TST group showed shorter TMS latency and higher genioglossus EMG activity, which lasted from 5 min to 80 min after training on day 56 of training, than the NC group. The TST group showed significantly lower theoretical Pcrit values on days 28 and 56 of training than the NC group (-4.07± 0.92 vs -3.12± 0.77 cmH2O, P< 0.05, -4.66± 0.74 vs -3.07± 0.38 cmH2O, P< 0.01).Conclusion: This study revealed that an 8-week TST could gradually and transiently increase corticomotor excitability of genioglossus, elevate the genioglossus EMG activity, and ultimately enhance the stability of the upper airway during daytime. Moreover, improved neuromuscular excitability occurred prior to the enhanced upper airway stability. These findings provide a theoretical foundation for TST as a promising treatment for OSA patients.Keywords: tongue strength training, genioglossus, upper airway critical pressure, transcranial magnetic stimulation, corticomotor excitabilityHuang HLi WJin HZhang LWei ZWang WDove Medical Pressarticletongue strength traininggenioglossusupper airway critical pressuretranscranial magnetic stimulationcorticomotor excitabilityPsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol Volume 13, Pp 1653-1661 (2021) |
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tongue strength training genioglossus upper airway critical pressure transcranial magnetic stimulation corticomotor excitability Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 |
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tongue strength training genioglossus upper airway critical pressure transcranial magnetic stimulation corticomotor excitability Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Huang H Li W Jin H Zhang L Wei Z Wang W Tongue Strength Training Increases Daytime Upper Airway Stability in Rats |
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Hong Huang, Wenyang Li, Hongyu Jin, Lei Zhang, Zhijing Wei, Wei Wang Institute of Respiratory and Critical Care, The First Hospital of China Medical University, Shenyang, People’s Republic of ChinaCorrespondence: Wei WangInstitute of Respiratory and Critical Care, The First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, Liaoning, 110001, People’s Republic of ChinaTel +86 24 83282529Fax +86 2483282002Email wwbycmu@126.comPurpose: Tongue strength training (TST) has been shown to decrease the apnea-hypopnea index in some patients with obstructive sleep apnea (OSA). However, whether TST modulates the central regulation of genioglossus and influences the stability of the upper airway remains unknown. The purpose of this study was to dynamically assess the effect of TST on the upper airway.Methods: Sixteen adult male Sprague–Dawley rats were studied to explore the mechanism of TST improving the upper airway function. The rats were randomly assigned to the normal control (NC) and TST groups. The TST group underwent 8-week progressive resistance tongue exercise training. Transcranial magnetic stimulation (TMS) responses and EMG activities were consistently recorded for 2 h on days 0, 14, 28, and 56 of the experiments in both groups. Theoretical critical pressure (Pcrit) value was measured on days 0, 14, 28, and 56.Results: The TST group showed shorter TMS latency and higher genioglossus EMG activity, which lasted from 5 min to 80 min after training on day 56 of training, than the NC group. The TST group showed significantly lower theoretical Pcrit values on days 28 and 56 of training than the NC group (-4.07± 0.92 vs -3.12± 0.77 cmH2O, P< 0.05, -4.66± 0.74 vs -3.07± 0.38 cmH2O, P< 0.01).Conclusion: This study revealed that an 8-week TST could gradually and transiently increase corticomotor excitability of genioglossus, elevate the genioglossus EMG activity, and ultimately enhance the stability of the upper airway during daytime. Moreover, improved neuromuscular excitability occurred prior to the enhanced upper airway stability. These findings provide a theoretical foundation for TST as a promising treatment for OSA patients.Keywords: tongue strength training, genioglossus, upper airway critical pressure, transcranial magnetic stimulation, corticomotor excitability |
| format |
article |
| author |
Huang H Li W Jin H Zhang L Wei Z Wang W |
| author_facet |
Huang H Li W Jin H Zhang L Wei Z Wang W |
| author_sort |
Huang H |
| title |
Tongue Strength Training Increases Daytime Upper Airway Stability in Rats |
| title_short |
Tongue Strength Training Increases Daytime Upper Airway Stability in Rats |
| title_full |
Tongue Strength Training Increases Daytime Upper Airway Stability in Rats |
| title_fullStr |
Tongue Strength Training Increases Daytime Upper Airway Stability in Rats |
| title_full_unstemmed |
Tongue Strength Training Increases Daytime Upper Airway Stability in Rats |
| title_sort |
tongue strength training increases daytime upper airway stability in rats |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/5f6e538c2fb8403fadfe4c5b6d969af3 |
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