Current Knowledge in Genetics, Molecular Diagnostic Tools, and Treatments for Mantle Cell Lymphomas

Mantle Cell lymphoma (MCL) is a mature B-cell lymphoma with a well-known hallmark genetic alteration in most cases, t (11,14)(q13q32)/CCND1-IGH. However, our understanding of the genetic and epigenetic alterations in MCL has evolved over the years, and it is now known that translocations involving C...

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Autores principales:	Shenon Sethi, Zachary Epstein-Peterson, Anita Kumar, Caleb Ho
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	mantle cell lymphoma genetic epigenetic molecular diagnostics immunochemotherapy targeted therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/5f6ee5b47fbc4382af261981744ce33d
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spelling	oai:doaj.org-article:5f6ee5b47fbc4382af261981744ce33d2021-11-30T12:27:23ZCurrent Knowledge in Genetics, Molecular Diagnostic Tools, and Treatments for Mantle Cell Lymphomas2234-943X10.3389/fonc.2021.739441https://doaj.org/article/5f6ee5b47fbc4382af261981744ce33d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.739441/fullhttps://doaj.org/toc/2234-943XMantle Cell lymphoma (MCL) is a mature B-cell lymphoma with a well-known hallmark genetic alteration in most cases, t (11,14)(q13q32)/CCND1-IGH. However, our understanding of the genetic and epigenetic alterations in MCL has evolved over the years, and it is now known that translocations involving CCND2, or cryptic insertion of enhancer elements of IGK or IGL gene, can also lead to MCL. On a molecular level, MCL can be broadly classified into two subtypes, conventional MCL (cMCL) and non-nodal MCL (nnMCL), each with different postulated tumor cell origin, clinical presentation and behavior, mutational pattern as well as genomic complexity. This article reviews both the common and rare alterations in MCL on a gene mutational, chromosomal arm, and epigenetic level, in the context of their contribution to the lymphomagenesis and disease evolution in MCL. This article also summarizes the important prognostic factors, molecular diagnostic tools, and treatment options based on the most recent MCL literature.Shenon SethiZachary Epstein-PetersonAnita KumarCaleb HoFrontiers Media S.A.articlemantle cell lymphomageneticepigeneticmolecular diagnosticsimmunochemotherapytargeted therapyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mantle cell lymphoma genetic epigenetic molecular diagnostics immunochemotherapy targeted therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	mantle cell lymphoma genetic epigenetic molecular diagnostics immunochemotherapy targeted therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Shenon Sethi Zachary Epstein-Peterson Anita Kumar Caleb Ho Current Knowledge in Genetics, Molecular Diagnostic Tools, and Treatments for Mantle Cell Lymphomas
description	Mantle Cell lymphoma (MCL) is a mature B-cell lymphoma with a well-known hallmark genetic alteration in most cases, t (11,14)(q13q32)/CCND1-IGH. However, our understanding of the genetic and epigenetic alterations in MCL has evolved over the years, and it is now known that translocations involving CCND2, or cryptic insertion of enhancer elements of IGK or IGL gene, can also lead to MCL. On a molecular level, MCL can be broadly classified into two subtypes, conventional MCL (cMCL) and non-nodal MCL (nnMCL), each with different postulated tumor cell origin, clinical presentation and behavior, mutational pattern as well as genomic complexity. This article reviews both the common and rare alterations in MCL on a gene mutational, chromosomal arm, and epigenetic level, in the context of their contribution to the lymphomagenesis and disease evolution in MCL. This article also summarizes the important prognostic factors, molecular diagnostic tools, and treatment options based on the most recent MCL literature.
format	article
author	Shenon Sethi Zachary Epstein-Peterson Anita Kumar Caleb Ho
author_facet	Shenon Sethi Zachary Epstein-Peterson Anita Kumar Caleb Ho
author_sort	Shenon Sethi
title	Current Knowledge in Genetics, Molecular Diagnostic Tools, and Treatments for Mantle Cell Lymphomas
title_short	Current Knowledge in Genetics, Molecular Diagnostic Tools, and Treatments for Mantle Cell Lymphomas
title_full	Current Knowledge in Genetics, Molecular Diagnostic Tools, and Treatments for Mantle Cell Lymphomas
title_fullStr	Current Knowledge in Genetics, Molecular Diagnostic Tools, and Treatments for Mantle Cell Lymphomas
title_full_unstemmed	Current Knowledge in Genetics, Molecular Diagnostic Tools, and Treatments for Mantle Cell Lymphomas
title_sort	current knowledge in genetics, molecular diagnostic tools, and treatments for mantle cell lymphomas
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/5f6ee5b47fbc4382af261981744ce33d
work_keys_str_mv	AT shenonsethi currentknowledgeingeneticsmoleculardiagnostictoolsandtreatmentsformantlecelllymphomas AT zacharyepsteinpeterson currentknowledgeingeneticsmoleculardiagnostictoolsandtreatmentsformantlecelllymphomas AT anitakumar currentknowledgeingeneticsmoleculardiagnostictoolsandtreatmentsformantlecelllymphomas AT calebho currentknowledgeingeneticsmoleculardiagnostictoolsandtreatmentsformantlecelllymphomas
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Current Knowledge in Genetics, Molecular Diagnostic Tools, and Treatments for Mantle Cell Lymphomas

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