Reliability and validity of the CogState battery Chinese language version in schizophrenia.

<h4>Background</h4>Cognitive impairment in patients with schizophrenia is a core symptom of this disease. The computerized CogState Battery (CSB) has been used to detect seven of the most common cognitive domains in schizophrenia. The aim of this study was to examine the reliability and...

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Autores principales: Na Zhong, Haifeng Jiang, Jin Wu, Hong Chen, Shuxing Lin, Yan Zhao, Jiang Du, Xiancang Ma, Ce Chen, Chengge Gao, Kenji Hashimoto, Min Zhao
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Publicado: Public Library of Science (PLoS) 2013
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spelling oai:doaj.org-article:5f6fa9cf52244f84a0b80a060175d47f2021-11-18T08:57:18ZReliability and validity of the CogState battery Chinese language version in schizophrenia.1932-620310.1371/journal.pone.0074258https://doaj.org/article/5f6fa9cf52244f84a0b80a060175d47f2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24023931/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Cognitive impairment in patients with schizophrenia is a core symptom of this disease. The computerized CogState Battery (CSB) has been used to detect seven of the most common cognitive domains in schizophrenia. The aim of this study was to examine the reliability and validity of the Chinese version of the CSB (CSB-C), in Chinese patients with schizophrenia.<h4>Methodology/principal findings</h4>Sixty Chinese patients with schizophrenia and 58 age, sex, and education matched healthy controls were enrolled. All subjects completed the CSB-C and the Repeated Battery for the Assessment of Neuropsychological Status (RBANS). To examine the test-retest reliability of CSB-C, we tested 33 healthy controls twice, at a one month interval. The Cronbach α value of CSB-C in patients was 0.81. The test-retest correlation coefficients of the Two Back Task, Gronton Maze Learning Task, Social Emotional Cognition Task, and Continuous Paired Association Learning Task were between 0.39 and 0.62 (p<0.01) in healthy controls. The composite scores and all subscores for the CSB-C in patients were significantly (p<0.01) lower than those of healthy controls. Furthermore, composite scores for patients on the RBANS were also significantly lower than those of healthy controls. Interestingly, there was a positive correlation (r = 0.544, p<0.001) between the composite scores on CSB-C and RBANS for patients. Additionally, in the attention and memory cognitive domains, corresponding subsets from the two batteries correlated significantly (p<0.05). Moreover, factor analysis showed a two-factor model, consisting of speed, memory and reasoning.<h4>Conclusions/significance</h4>The CSB-C shows good reliability and validity in measuring the broad cognitive domains of schizophrenia in affected Chinese patients. Therefore, the CSB-C can be used as a cognitive battery, to assess the therapeutic effects of potential cognitive-enhancing agents in this cohort.Na ZhongHaifeng JiangJin WuHong ChenShuxing LinYan ZhaoJiang DuXiancang MaCe ChenChengge GaoKenji HashimotoMin ZhaoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e74258 (2013)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Na Zhong
Haifeng Jiang
Jin Wu
Hong Chen
Shuxing Lin
Yan Zhao
Jiang Du
Xiancang Ma
Ce Chen
Chengge Gao
Kenji Hashimoto
Min Zhao
Reliability and validity of the CogState battery Chinese language version in schizophrenia.
description <h4>Background</h4>Cognitive impairment in patients with schizophrenia is a core symptom of this disease. The computerized CogState Battery (CSB) has been used to detect seven of the most common cognitive domains in schizophrenia. The aim of this study was to examine the reliability and validity of the Chinese version of the CSB (CSB-C), in Chinese patients with schizophrenia.<h4>Methodology/principal findings</h4>Sixty Chinese patients with schizophrenia and 58 age, sex, and education matched healthy controls were enrolled. All subjects completed the CSB-C and the Repeated Battery for the Assessment of Neuropsychological Status (RBANS). To examine the test-retest reliability of CSB-C, we tested 33 healthy controls twice, at a one month interval. The Cronbach α value of CSB-C in patients was 0.81. The test-retest correlation coefficients of the Two Back Task, Gronton Maze Learning Task, Social Emotional Cognition Task, and Continuous Paired Association Learning Task were between 0.39 and 0.62 (p<0.01) in healthy controls. The composite scores and all subscores for the CSB-C in patients were significantly (p<0.01) lower than those of healthy controls. Furthermore, composite scores for patients on the RBANS were also significantly lower than those of healthy controls. Interestingly, there was a positive correlation (r = 0.544, p<0.001) between the composite scores on CSB-C and RBANS for patients. Additionally, in the attention and memory cognitive domains, corresponding subsets from the two batteries correlated significantly (p<0.05). Moreover, factor analysis showed a two-factor model, consisting of speed, memory and reasoning.<h4>Conclusions/significance</h4>The CSB-C shows good reliability and validity in measuring the broad cognitive domains of schizophrenia in affected Chinese patients. Therefore, the CSB-C can be used as a cognitive battery, to assess the therapeutic effects of potential cognitive-enhancing agents in this cohort.
format article
author Na Zhong
Haifeng Jiang
Jin Wu
Hong Chen
Shuxing Lin
Yan Zhao
Jiang Du
Xiancang Ma
Ce Chen
Chengge Gao
Kenji Hashimoto
Min Zhao
author_facet Na Zhong
Haifeng Jiang
Jin Wu
Hong Chen
Shuxing Lin
Yan Zhao
Jiang Du
Xiancang Ma
Ce Chen
Chengge Gao
Kenji Hashimoto
Min Zhao
author_sort Na Zhong
title Reliability and validity of the CogState battery Chinese language version in schizophrenia.
title_short Reliability and validity of the CogState battery Chinese language version in schizophrenia.
title_full Reliability and validity of the CogState battery Chinese language version in schizophrenia.
title_fullStr Reliability and validity of the CogState battery Chinese language version in schizophrenia.
title_full_unstemmed Reliability and validity of the CogState battery Chinese language version in schizophrenia.
title_sort reliability and validity of the cogstate battery chinese language version in schizophrenia.
publisher Public Library of Science (PLoS)
publishDate 2013
url https://doaj.org/article/5f6fa9cf52244f84a0b80a060175d47f
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