Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes

Dimethyl fumarate (DMF) is an established treatment for relapsing multiple sclerosis with unclear mechanism of action. Here the authors distinguish DMF responders by monocyte counts and redox gene signature in a prospective longitudinal cohort at 3 month of therapy, and associate NOX3 genetic varian...

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Autores principales:	Karl E. Carlström, Ewoud Ewing, Mathias Granqvist, Alexandra Gyllenberg, Shahin Aeinehband, Sara Lind Enoksson, Antonio Checa, Tejaswi V. S. Badam, Jesse Huang, David Gomez-Cabrero, Mika Gustafsson, Faiez Al Nimer, Craig E. Wheelock, Ingrid Kockum, Tomas Olsson, Maja Jagodic, Fredrik Piehl
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5f74917254ed42d7852010fdaa94f8a7
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spelling	oai:doaj.org-article:5f74917254ed42d7852010fdaa94f8a72021-12-02T16:57:44ZTherapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes10.1038/s41467-019-11139-32041-1723https://doaj.org/article/5f74917254ed42d7852010fdaa94f8a72019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11139-3https://doaj.org/toc/2041-1723Dimethyl fumarate (DMF) is an established treatment for relapsing multiple sclerosis with unclear mechanism of action. Here the authors distinguish DMF responders by monocyte counts and redox gene signature in a prospective longitudinal cohort at 3 month of therapy, and associate NOX3 genetic variants with outcome.Karl E. CarlströmEwoud EwingMathias GranqvistAlexandra GyllenbergShahin AeinehbandSara Lind EnokssonAntonio ChecaTejaswi V. S. BadamJesse HuangDavid Gomez-CabreroMika GustafssonFaiez Al NimerCraig E. WheelockIngrid KockumTomas OlssonMaja JagodicFredrik PiehlNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Karl E. Carlström Ewoud Ewing Mathias Granqvist Alexandra Gyllenberg Shahin Aeinehband Sara Lind Enoksson Antonio Checa Tejaswi V. S. Badam Jesse Huang David Gomez-Cabrero Mika Gustafsson Faiez Al Nimer Craig E. Wheelock Ingrid Kockum Tomas Olsson Maja Jagodic Fredrik Piehl Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes
description	Dimethyl fumarate (DMF) is an established treatment for relapsing multiple sclerosis with unclear mechanism of action. Here the authors distinguish DMF responders by monocyte counts and redox gene signature in a prospective longitudinal cohort at 3 month of therapy, and associate NOX3 genetic variants with outcome.
format	article
author	Karl E. Carlström Ewoud Ewing Mathias Granqvist Alexandra Gyllenberg Shahin Aeinehband Sara Lind Enoksson Antonio Checa Tejaswi V. S. Badam Jesse Huang David Gomez-Cabrero Mika Gustafsson Faiez Al Nimer Craig E. Wheelock Ingrid Kockum Tomas Olsson Maja Jagodic Fredrik Piehl
author_facet	Karl E. Carlström Ewoud Ewing Mathias Granqvist Alexandra Gyllenberg Shahin Aeinehband Sara Lind Enoksson Antonio Checa Tejaswi V. S. Badam Jesse Huang David Gomez-Cabrero Mika Gustafsson Faiez Al Nimer Craig E. Wheelock Ingrid Kockum Tomas Olsson Maja Jagodic Fredrik Piehl
author_sort	Karl E. Carlström
title	Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes
title_short	Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes
title_full	Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes
title_fullStr	Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes
title_full_unstemmed	Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes
title_sort	therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ros pathway in monocytes
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/5f74917254ed42d7852010fdaa94f8a7
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Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes

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