Dead cells release a ‘necrosignal’ that activates antibiotic survival pathways in bacterial swarms

Swarming bacterial populations can exhibit antibiotic resistance, despite sustaining considerable cell death. Here, Bhattacharyya et al. show that killed cells release periplasmic protein AcrA, which activates efflux pumps on the surface of live cells, thus enhancing antibiotic resistance in the sur...

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Autores principales: Souvik Bhattacharyya, David M. Walker, Rasika M. Harshey
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/5f74f736fab24ecc83c661f5a3a39072
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Sumario:Swarming bacterial populations can exhibit antibiotic resistance, despite sustaining considerable cell death. Here, Bhattacharyya et al. show that killed cells release periplasmic protein AcrA, which activates efflux pumps on the surface of live cells, thus enhancing antibiotic resistance in the surviving cells.