Dead cells release a ‘necrosignal’ that activates antibiotic survival pathways in bacterial swarms

Swarming bacterial populations can exhibit antibiotic resistance, despite sustaining considerable cell death. Here, Bhattacharyya et al. show that killed cells release periplasmic protein AcrA, which activates efflux pumps on the surface of live cells, thus enhancing antibiotic resistance in the sur...

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Autores principales:	Souvik Bhattacharyya, David M. Walker, Rasika M. Harshey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5f74f736fab24ecc83c661f5a3a39072
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spelling	oai:doaj.org-article:5f74f736fab24ecc83c661f5a3a390722021-12-02T18:00:10ZDead cells release a ‘necrosignal’ that activates antibiotic survival pathways in bacterial swarms10.1038/s41467-020-17709-02041-1723https://doaj.org/article/5f74f736fab24ecc83c661f5a3a390722020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17709-0https://doaj.org/toc/2041-1723Swarming bacterial populations can exhibit antibiotic resistance, despite sustaining considerable cell death. Here, Bhattacharyya et al. show that killed cells release periplasmic protein AcrA, which activates efflux pumps on the surface of live cells, thus enhancing antibiotic resistance in the surviving cells.Souvik BhattacharyyaDavid M. WalkerRasika M. HarsheyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Souvik Bhattacharyya David M. Walker Rasika M. Harshey Dead cells release a ‘necrosignal’ that activates antibiotic survival pathways in bacterial swarms
description	Swarming bacterial populations can exhibit antibiotic resistance, despite sustaining considerable cell death. Here, Bhattacharyya et al. show that killed cells release periplasmic protein AcrA, which activates efflux pumps on the surface of live cells, thus enhancing antibiotic resistance in the surviving cells.
format	article
author	Souvik Bhattacharyya David M. Walker Rasika M. Harshey
author_facet	Souvik Bhattacharyya David M. Walker Rasika M. Harshey
author_sort	Souvik Bhattacharyya
title	Dead cells release a ‘necrosignal’ that activates antibiotic survival pathways in bacterial swarms
title_short	Dead cells release a ‘necrosignal’ that activates antibiotic survival pathways in bacterial swarms
title_full	Dead cells release a ‘necrosignal’ that activates antibiotic survival pathways in bacterial swarms
title_fullStr	Dead cells release a ‘necrosignal’ that activates antibiotic survival pathways in bacterial swarms
title_full_unstemmed	Dead cells release a ‘necrosignal’ that activates antibiotic survival pathways in bacterial swarms
title_sort	dead cells release a ‘necrosignal’ that activates antibiotic survival pathways in bacterial swarms
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5f74f736fab24ecc83c661f5a3a39072
work_keys_str_mv	AT souvikbhattacharyya deadcellsreleaseanecrosignalthatactivatesantibioticsurvivalpathwaysinbacterialswarms AT davidmwalker deadcellsreleaseanecrosignalthatactivatesantibioticsurvivalpathwaysinbacterialswarms AT rasikamharshey deadcellsreleaseanecrosignalthatactivatesantibioticsurvivalpathwaysinbacterialswarms
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Dead cells release a ‘necrosignal’ that activates antibiotic survival pathways in bacterial swarms

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