Enhanced NF-κB signaling in type-2 dendritic cells at baseline predicts non-response to adalimumab in psoriasis

Enhanced NF-κB signaling in type-2 dendritic cells at baseline predicts non-response to adalimumab in psoriasis

Biomarkers to indicate potential response to biologic therapeutics are needed for patients with psoriasis. Here the authors show that phosphorylation of NFκBp65 in cDC2 before therapy is an indication of non-response to the anti-TNF therapy adalimumab in patients with psoriasis.

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Autores principales: Rosa Andres-Ejarque, Hira Bahadur Ale, Katarzyna Grys, Isabella Tosi, Shane Solanky, Chrysanthi Ainali, Zeynep Catak, Hemawtee Sreeneebus, Jake Saklatvala, Nick Dand, Emanuele de Rinaldis, Anna Chapman, Frank O. Nestle, Michael R. Barnes, Richard B. Warren, Nick J. Reynolds, Christopher E. M. Griffiths, Jonathan N. Barker, Catherine H. Smith, Paola Di Meglio, the PSORT Consortium
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
Q
Acceso en línea:https://doaj.org/article/5f76b87e60c641cb804dbde9f569fb55
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spelling oai:doaj.org-article:5f76b87e60c641cb804dbde9f569fb552021-12-02T16:34:05ZEnhanced NF-κB signaling in type-2 dendritic cells at baseline predicts non-response to adalimumab in psoriasis10.1038/s41467-021-25066-92041-1723https://doaj.org/article/5f76b87e60c641cb804dbde9f569fb552021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25066-9https://doaj.org/toc/2041-1723Biomarkers to indicate potential response to biologic therapeutics are needed for patients with psoriasis. Here the authors show that phosphorylation of NFκBp65 in cDC2 before therapy is an indication of non-response to the anti-TNF therapy adalimumab in patients with psoriasis.Rosa Andres-EjarqueHira Bahadur AleKatarzyna GrysIsabella TosiShane SolankyChrysanthi AinaliZeynep CatakHemawtee SreeneebusJake SaklatvalaNick DandEmanuele de RinaldisAnna ChapmanFrank O. NestleMichael R. BarnesRichard B. WarrenNick J. ReynoldsChristopher E. M. GriffithsJonathan N. BarkerCatherine H. SmithPaola Di Megliothe PSORT ConsortiumNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Rosa Andres-Ejarque
Hira Bahadur Ale
Katarzyna Grys
Isabella Tosi
Shane Solanky
Chrysanthi Ainali
Zeynep Catak
Hemawtee Sreeneebus
Jake Saklatvala
Nick Dand
Emanuele de Rinaldis
Anna Chapman
Frank O. Nestle
Michael R. Barnes
Richard B. Warren
Nick J. Reynolds
Christopher E. M. Griffiths
Jonathan N. Barker
Catherine H. Smith
Paola Di Meglio
the PSORT Consortium
Enhanced NF-κB signaling in type-2 dendritic cells at baseline predicts non-response to adalimumab in psoriasis
description Biomarkers to indicate potential response to biologic therapeutics are needed for patients with psoriasis. Here the authors show that phosphorylation of NFκBp65 in cDC2 before therapy is an indication of non-response to the anti-TNF therapy adalimumab in patients with psoriasis.
format article
author Rosa Andres-Ejarque
Hira Bahadur Ale
Katarzyna Grys
Isabella Tosi
Shane Solanky
Chrysanthi Ainali
Zeynep Catak
Hemawtee Sreeneebus
Jake Saklatvala
Nick Dand
Emanuele de Rinaldis
Anna Chapman
Frank O. Nestle
Michael R. Barnes
Richard B. Warren
Nick J. Reynolds
Christopher E. M. Griffiths
Jonathan N. Barker
Catherine H. Smith
Paola Di Meglio
the PSORT Consortium
author_facet Rosa Andres-Ejarque
Hira Bahadur Ale
Katarzyna Grys
Isabella Tosi
Shane Solanky
Chrysanthi Ainali
Zeynep Catak
Hemawtee Sreeneebus
Jake Saklatvala
Nick Dand
Emanuele de Rinaldis
Anna Chapman
Frank O. Nestle
Michael R. Barnes
Richard B. Warren
Nick J. Reynolds
Christopher E. M. Griffiths
Jonathan N. Barker
Catherine H. Smith
Paola Di Meglio
the PSORT Consortium
author_sort Rosa Andres-Ejarque
title Enhanced NF-κB signaling in type-2 dendritic cells at baseline predicts non-response to adalimumab in psoriasis
title_short Enhanced NF-κB signaling in type-2 dendritic cells at baseline predicts non-response to adalimumab in psoriasis
title_full Enhanced NF-κB signaling in type-2 dendritic cells at baseline predicts non-response to adalimumab in psoriasis
title_fullStr Enhanced NF-κB signaling in type-2 dendritic cells at baseline predicts non-response to adalimumab in psoriasis
title_full_unstemmed Enhanced NF-κB signaling in type-2 dendritic cells at baseline predicts non-response to adalimumab in psoriasis
title_sort enhanced nf-κb signaling in type-2 dendritic cells at baseline predicts non-response to adalimumab in psoriasis
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/5f76b87e60c641cb804dbde9f569fb55
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