Steroid-Induced Osteonecrosis of the Femoral Head: Novel Insight Into the Roles of Bone Endothelial Cells in Pathogenesis and Treatment

Steroid-induced osteonecrosis of the femoral head (SONFH) is a disease characterized by the collapse of the femoral head. SONFH occurs due to the overuse of glucocorticoids (GCs) in patients with immune-related diseases. Among various pathogenesis proposed, the mechanism related to impaired blood ve...

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Autores principales:	Cheng Huang, Zeqin Wen, Junjie Niu, Subin Lin, Weiguo Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	steroid-induced osteonecrosis of the femoral head bone endothelial cells bone microvascular endothelial cells bone progenitor cells angiogenesis pathogenesis Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5f779a1fa83d4eeab4e5c3b27d727a5b
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spelling	oai:doaj.org-article:5f779a1fa83d4eeab4e5c3b27d727a5b2021-12-02T01:37:10ZSteroid-Induced Osteonecrosis of the Femoral Head: Novel Insight Into the Roles of Bone Endothelial Cells in Pathogenesis and Treatment2296-634X10.3389/fcell.2021.777697https://doaj.org/article/5f779a1fa83d4eeab4e5c3b27d727a5b2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.777697/fullhttps://doaj.org/toc/2296-634XSteroid-induced osteonecrosis of the femoral head (SONFH) is a disease characterized by the collapse of the femoral head. SONFH occurs due to the overuse of glucocorticoids (GCs) in patients with immune-related diseases. Among various pathogenesis proposed, the mechanism related to impaired blood vessels is gradually becoming the most convincing hypothesis. Bone endothelial cells including bone microvascular endothelial cells (BMECs) and endothelial progenitor cells (EPCs) play a crucial role in the maintenance of vascular homeostasis. Therefore, bone endothelial cells are key regulators in the occurrence and progression of SONFH. Impaired angiogenesis, abnormal apoptosis, thrombosis and fat embolism caused by the dysfunctions of bone endothelial cells are considered to be the pathogenesis of SONFH. In addition, even with high disability rates, SONFH lacks effective therapeutic approach. Icariin (ICA, a flavonoid extracted from Epimedii Herba), pravastatin, and VO-OHpic (a potent inhibitor of PTEN) are candidate reagents to prevent and treat SONFH through improving above pathological processes. However, these reagents are still in the preclinical stage and will not be widely used temporarily. In this case, bone tissue engineering represented by co-transplantation of bone endothelial cells and bone marrow mesenchymal stem cells (BMSCs) may be another feasible therapeutic strategy.Cheng HuangZeqin WenJunjie NiuSubin LinWeiguo WangFrontiers Media S.A.articlesteroid-induced osteonecrosis of the femoral headbone endothelial cellsbone microvascular endothelial cellsbone progenitor cellsangiogenesispathogenesisBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	steroid-induced osteonecrosis of the femoral head bone endothelial cells bone microvascular endothelial cells bone progenitor cells angiogenesis pathogenesis Biology (General) QH301-705.5
spellingShingle	steroid-induced osteonecrosis of the femoral head bone endothelial cells bone microvascular endothelial cells bone progenitor cells angiogenesis pathogenesis Biology (General) QH301-705.5 Cheng Huang Zeqin Wen Junjie Niu Subin Lin Weiguo Wang Steroid-Induced Osteonecrosis of the Femoral Head: Novel Insight Into the Roles of Bone Endothelial Cells in Pathogenesis and Treatment
description	Steroid-induced osteonecrosis of the femoral head (SONFH) is a disease characterized by the collapse of the femoral head. SONFH occurs due to the overuse of glucocorticoids (GCs) in patients with immune-related diseases. Among various pathogenesis proposed, the mechanism related to impaired blood vessels is gradually becoming the most convincing hypothesis. Bone endothelial cells including bone microvascular endothelial cells (BMECs) and endothelial progenitor cells (EPCs) play a crucial role in the maintenance of vascular homeostasis. Therefore, bone endothelial cells are key regulators in the occurrence and progression of SONFH. Impaired angiogenesis, abnormal apoptosis, thrombosis and fat embolism caused by the dysfunctions of bone endothelial cells are considered to be the pathogenesis of SONFH. In addition, even with high disability rates, SONFH lacks effective therapeutic approach. Icariin (ICA, a flavonoid extracted from Epimedii Herba), pravastatin, and VO-OHpic (a potent inhibitor of PTEN) are candidate reagents to prevent and treat SONFH through improving above pathological processes. However, these reagents are still in the preclinical stage and will not be widely used temporarily. In this case, bone tissue engineering represented by co-transplantation of bone endothelial cells and bone marrow mesenchymal stem cells (BMSCs) may be another feasible therapeutic strategy.
format	article
author	Cheng Huang Zeqin Wen Junjie Niu Subin Lin Weiguo Wang
author_facet	Cheng Huang Zeqin Wen Junjie Niu Subin Lin Weiguo Wang
author_sort	Cheng Huang
title	Steroid-Induced Osteonecrosis of the Femoral Head: Novel Insight Into the Roles of Bone Endothelial Cells in Pathogenesis and Treatment
title_short	Steroid-Induced Osteonecrosis of the Femoral Head: Novel Insight Into the Roles of Bone Endothelial Cells in Pathogenesis and Treatment
title_full	Steroid-Induced Osteonecrosis of the Femoral Head: Novel Insight Into the Roles of Bone Endothelial Cells in Pathogenesis and Treatment
title_fullStr	Steroid-Induced Osteonecrosis of the Femoral Head: Novel Insight Into the Roles of Bone Endothelial Cells in Pathogenesis and Treatment
title_full_unstemmed	Steroid-Induced Osteonecrosis of the Femoral Head: Novel Insight Into the Roles of Bone Endothelial Cells in Pathogenesis and Treatment
title_sort	steroid-induced osteonecrosis of the femoral head: novel insight into the roles of bone endothelial cells in pathogenesis and treatment
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/5f779a1fa83d4eeab4e5c3b27d727a5b
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Steroid-Induced Osteonecrosis of the Femoral Head: Novel Insight Into the Roles of Bone Endothelial Cells in Pathogenesis and Treatment

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