Pathological findings after third- and second-generation everolimus-eluting stent implantations in coronary arteries from autopsy cases and an atherosclerotic porcine model
Abstract Pathological changes after third-generation drug-eluting stent implantation remain unclear. We compared the tissue responses of coronary arteries after the implantation of third-generation abluminal biodegradable-polymer everolimus-eluting stent (3rd EES) and second-generation durable-polym...
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Nature Portfolio
2021
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oai:doaj.org-article:5f787f17960e4d93952e00f2257a5f642021-12-02T11:39:43ZPathological findings after third- and second-generation everolimus-eluting stent implantations in coronary arteries from autopsy cases and an atherosclerotic porcine model10.1038/s41598-021-85740-22045-2322https://doaj.org/article/5f787f17960e4d93952e00f2257a5f642021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85740-2https://doaj.org/toc/2045-2322Abstract Pathological changes after third-generation drug-eluting stent implantation remain unclear. We compared the tissue responses of coronary arteries after the implantation of third-generation abluminal biodegradable-polymer everolimus-eluting stent (3rd EES) and second-generation durable-polymer EES (2nd EES) using autopsy specimens and an atherosclerotic porcine model. We compared the histology of stented coronary arteries obtained by autopsy performed 1–10 months after 3rd EES (n (number of cases) = 4, stent-implanted period of 3–7 months) and 2nd EES (n (number of cases) = 9, stent-implanted period of 1–10 months) implantations. The ratio of covered stent struts was higher with 3rd EESs than with 2nd EESs (3rd; 0.824 ± 0.032 vs. 2nd; 0.736 ± 0.022, p = 0.035). Low-density lipoprotein receptor knockout minipigs were stented with 3rd or 2nd EES in the coronary arteries and the stented regions were investigated. The fibrin deposition around the 2nd EES was more prominent. Additionally, higher density of smooth muscle cells was confirmed after the 3rd EES implantation. Pathological examination after the 3rd EES demonstrated a combination of less fibrin deposition and more rapid acquisition of well-developed neointima as compared to the 2nd EES at autopsy and the atherosclerotic porcine model.Suguru MigitaDaisuke KitanoYuxin LiYutaka KoyamaSayaka Shimodai-YamadaAkira OnishiDaiichiro FuchimotoShunichi SuzukiYoshiyuki NakamuraTaka-aki MatsuyamaSeiichi HirotaMasashi SakumaMasahiko TsujimotoAtsushi HirayamaYasuo OkumuraHiroyuki HaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021) |
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Medicine R Science Q Suguru Migita Daisuke Kitano Yuxin Li Yutaka Koyama Sayaka Shimodai-Yamada Akira Onishi Daiichiro Fuchimoto Shunichi Suzuki Yoshiyuki Nakamura Taka-aki Matsuyama Seiichi Hirota Masashi Sakuma Masahiko Tsujimoto Atsushi Hirayama Yasuo Okumura Hiroyuki Hao Pathological findings after third- and second-generation everolimus-eluting stent implantations in coronary arteries from autopsy cases and an atherosclerotic porcine model |
| description |
Abstract Pathological changes after third-generation drug-eluting stent implantation remain unclear. We compared the tissue responses of coronary arteries after the implantation of third-generation abluminal biodegradable-polymer everolimus-eluting stent (3rd EES) and second-generation durable-polymer EES (2nd EES) using autopsy specimens and an atherosclerotic porcine model. We compared the histology of stented coronary arteries obtained by autopsy performed 1–10 months after 3rd EES (n (number of cases) = 4, stent-implanted period of 3–7 months) and 2nd EES (n (number of cases) = 9, stent-implanted period of 1–10 months) implantations. The ratio of covered stent struts was higher with 3rd EESs than with 2nd EESs (3rd; 0.824 ± 0.032 vs. 2nd; 0.736 ± 0.022, p = 0.035). Low-density lipoprotein receptor knockout minipigs were stented with 3rd or 2nd EES in the coronary arteries and the stented regions were investigated. The fibrin deposition around the 2nd EES was more prominent. Additionally, higher density of smooth muscle cells was confirmed after the 3rd EES implantation. Pathological examination after the 3rd EES demonstrated a combination of less fibrin deposition and more rapid acquisition of well-developed neointima as compared to the 2nd EES at autopsy and the atherosclerotic porcine model. |
| format |
article |
| author |
Suguru Migita Daisuke Kitano Yuxin Li Yutaka Koyama Sayaka Shimodai-Yamada Akira Onishi Daiichiro Fuchimoto Shunichi Suzuki Yoshiyuki Nakamura Taka-aki Matsuyama Seiichi Hirota Masashi Sakuma Masahiko Tsujimoto Atsushi Hirayama Yasuo Okumura Hiroyuki Hao |
| author_facet |
Suguru Migita Daisuke Kitano Yuxin Li Yutaka Koyama Sayaka Shimodai-Yamada Akira Onishi Daiichiro Fuchimoto Shunichi Suzuki Yoshiyuki Nakamura Taka-aki Matsuyama Seiichi Hirota Masashi Sakuma Masahiko Tsujimoto Atsushi Hirayama Yasuo Okumura Hiroyuki Hao |
| author_sort |
Suguru Migita |
| title |
Pathological findings after third- and second-generation everolimus-eluting stent implantations in coronary arteries from autopsy cases and an atherosclerotic porcine model |
| title_short |
Pathological findings after third- and second-generation everolimus-eluting stent implantations in coronary arteries from autopsy cases and an atherosclerotic porcine model |
| title_full |
Pathological findings after third- and second-generation everolimus-eluting stent implantations in coronary arteries from autopsy cases and an atherosclerotic porcine model |
| title_fullStr |
Pathological findings after third- and second-generation everolimus-eluting stent implantations in coronary arteries from autopsy cases and an atherosclerotic porcine model |
| title_full_unstemmed |
Pathological findings after third- and second-generation everolimus-eluting stent implantations in coronary arteries from autopsy cases and an atherosclerotic porcine model |
| title_sort |
pathological findings after third- and second-generation everolimus-eluting stent implantations in coronary arteries from autopsy cases and an atherosclerotic porcine model |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/5f787f17960e4d93952e00f2257a5f64 |
| work_keys_str_mv |
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