Structure and function of the Zika virus full-length NS5 protein

Zika virus infection can cause human birth defects and Guillain-Barré syndrome. Here the authors present the structures of the full-length nonstructural protein 5 and its RNA-dependent RNA polymerase domain of Zika virus, which are targets for inhibitors of virus replication.

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Autores principales: Baoyu Zhao, Guanghui Yi, Fenglei Du, Yin-Chih Chuang, Robert C. Vaughan, Banumathi Sankaran, C. Cheng Kao, Pingwei Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/5f7cf37477dd4b07ab2f1f59b91eee8b
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spelling oai:doaj.org-article:5f7cf37477dd4b07ab2f1f59b91eee8b2021-12-02T14:40:37ZStructure and function of the Zika virus full-length NS5 protein10.1038/ncomms147622041-1723https://doaj.org/article/5f7cf37477dd4b07ab2f1f59b91eee8b2017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14762https://doaj.org/toc/2041-1723Zika virus infection can cause human birth defects and Guillain-Barré syndrome. Here the authors present the structures of the full-length nonstructural protein 5 and its RNA-dependent RNA polymerase domain of Zika virus, which are targets for inhibitors of virus replication.Baoyu ZhaoGuanghui YiFenglei DuYin-Chih ChuangRobert C. VaughanBanumathi SankaranC. Cheng KaoPingwei LiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Baoyu Zhao
Guanghui Yi
Fenglei Du
Yin-Chih Chuang
Robert C. Vaughan
Banumathi Sankaran
C. Cheng Kao
Pingwei Li
Structure and function of the Zika virus full-length NS5 protein
description Zika virus infection can cause human birth defects and Guillain-Barré syndrome. Here the authors present the structures of the full-length nonstructural protein 5 and its RNA-dependent RNA polymerase domain of Zika virus, which are targets for inhibitors of virus replication.
format article
author Baoyu Zhao
Guanghui Yi
Fenglei Du
Yin-Chih Chuang
Robert C. Vaughan
Banumathi Sankaran
C. Cheng Kao
Pingwei Li
author_facet Baoyu Zhao
Guanghui Yi
Fenglei Du
Yin-Chih Chuang
Robert C. Vaughan
Banumathi Sankaran
C. Cheng Kao
Pingwei Li
author_sort Baoyu Zhao
title Structure and function of the Zika virus full-length NS5 protein
title_short Structure and function of the Zika virus full-length NS5 protein
title_full Structure and function of the Zika virus full-length NS5 protein
title_fullStr Structure and function of the Zika virus full-length NS5 protein
title_full_unstemmed Structure and function of the Zika virus full-length NS5 protein
title_sort structure and function of the zika virus full-length ns5 protein
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/5f7cf37477dd4b07ab2f1f59b91eee8b
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AT guanghuiyi structureandfunctionofthezikavirusfulllengthns5protein
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AT banumathisankaran structureandfunctionofthezikavirusfulllengthns5protein
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