Mitochondrial dysfunction, oxidative stress, and major depressive disorder

Edward H Tobe University of Medicine and Dentistry of New Jersey/School of Osteopathic Medicine, University of Medicine and Dentistry of New Jersey/Robert Wood Johnson Medical School, and Cooper Medical School of Rowan University, Camden, NJ, USA Abstract: There is controversy about depression being...

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Autor principal:	Tobe EH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/5f7ee33892484642a1e7317b53bde0dd
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spelling	oai:doaj.org-article:5f7ee33892484642a1e7317b53bde0dd2021-12-02T02:27:32ZMitochondrial dysfunction, oxidative stress, and major depressive disorder1176-63281178-2021https://doaj.org/article/5f7ee33892484642a1e7317b53bde0dd2013-04-01T00:00:00Zhttp://www.dovepress.com/mitochondrial-dysfunction-oxidative-stress-and-major-depressive-disord-a12898https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Edward H Tobe University of Medicine and Dentistry of New Jersey/School of Osteopathic Medicine, University of Medicine and Dentistry of New Jersey/Robert Wood Johnson Medical School, and Cooper Medical School of Rowan University, Camden, NJ, USA Abstract: There is controversy about depression being a physical illness, in part because a reproducible, sensitive, and specific biologic marker is not available. However, there is evidence that mitochondrial dysfunction and oxidative stress may be associated with abnormal brain function and mood disorders, such as depression. This paper reviews selected human and animal studies providing evidence that intracellular mitochondrial metabolic dysfunction in specific brain regions is associated with major depressive disorder. This supports the hypothesis that chronic mitochondrial dysfunction in specific tissues may be associated with depression. Evaluation of mitochondrial dysfunction in specific tissues may broaden the perspective of depression beyond theories about neurotransmitters or receptor sites, and may explain the persistent signs and symptoms of depression. Keywords: mitochondrial dysfunction, oxidative stress, major depressive disorder, depressionTobe EHDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2013, Iss default, Pp 567-573 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Tobe EH Mitochondrial dysfunction, oxidative stress, and major depressive disorder
description	Edward H Tobe University of Medicine and Dentistry of New Jersey/School of Osteopathic Medicine, University of Medicine and Dentistry of New Jersey/Robert Wood Johnson Medical School, and Cooper Medical School of Rowan University, Camden, NJ, USA Abstract: There is controversy about depression being a physical illness, in part because a reproducible, sensitive, and specific biologic marker is not available. However, there is evidence that mitochondrial dysfunction and oxidative stress may be associated with abnormal brain function and mood disorders, such as depression. This paper reviews selected human and animal studies providing evidence that intracellular mitochondrial metabolic dysfunction in specific brain regions is associated with major depressive disorder. This supports the hypothesis that chronic mitochondrial dysfunction in specific tissues may be associated with depression. Evaluation of mitochondrial dysfunction in specific tissues may broaden the perspective of depression beyond theories about neurotransmitters or receptor sites, and may explain the persistent signs and symptoms of depression. Keywords: mitochondrial dysfunction, oxidative stress, major depressive disorder, depression
format	article
author	Tobe EH
author_facet	Tobe EH
author_sort	Tobe EH
title	Mitochondrial dysfunction, oxidative stress, and major depressive disorder
title_short	Mitochondrial dysfunction, oxidative stress, and major depressive disorder
title_full	Mitochondrial dysfunction, oxidative stress, and major depressive disorder
title_fullStr	Mitochondrial dysfunction, oxidative stress, and major depressive disorder
title_full_unstemmed	Mitochondrial dysfunction, oxidative stress, and major depressive disorder
title_sort	mitochondrial dysfunction, oxidative stress, and major depressive disorder
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/5f7ee33892484642a1e7317b53bde0dd
work_keys_str_mv	AT tobeeh mitochondrialdysfunctionoxidativestressandmajordepressivedisorder
_version_	1718402470767493120

Mitochondrial dysfunction, oxidative stress, and major depressive disorder

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