Nance-Horan Syndrome-like 1 protein negatively regulates Scar/WAVE-Arp2/3 activity and inhibits lamellipodia stability and cell migration

Cell migration is essential for many physiological processes. Its deregulation causes cancer metastasis and it is not well understood how it is tightly controlled. We identify NHSL1 as a negative regulator of actin nucleating Scar/WAVE-Arp2/3 complexes, cell protrusion stability, and cell migration.

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Autores principales:	Ah-Lai Law, Shamsinar Jalal, Tommy Pallett, Fuad Mosis, Ahmad Guni, Simon Brayford, Lawrence Yolland, Stefania Marcotti, James A. Levitt, Simon P. Poland, Maia Rowe-Sampson, Anett Jandke, Robert Köchl, Giordano Pula, Simon M. Ameer-Beg, Brian Marc Stramer, Matthias Krause
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5f81f0f7930346ea95298ce9f59b6d60
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spelling	oai:doaj.org-article:5f81f0f7930346ea95298ce9f59b6d602021-12-02T17:37:36ZNance-Horan Syndrome-like 1 protein negatively regulates Scar/WAVE-Arp2/3 activity and inhibits lamellipodia stability and cell migration10.1038/s41467-021-25916-62041-1723https://doaj.org/article/5f81f0f7930346ea95298ce9f59b6d602021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25916-6https://doaj.org/toc/2041-1723Cell migration is essential for many physiological processes. Its deregulation causes cancer metastasis and it is not well understood how it is tightly controlled. We identify NHSL1 as a negative regulator of actin nucleating Scar/WAVE-Arp2/3 complexes, cell protrusion stability, and cell migration.Ah-Lai LawShamsinar JalalTommy PallettFuad MosisAhmad GuniSimon BrayfordLawrence YollandStefania MarcottiJames A. LevittSimon P. PolandMaia Rowe-SampsonAnett JandkeRobert KöchlGiordano PulaSimon M. Ameer-BegBrian Marc StramerMatthias KrauseNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ah-Lai Law Shamsinar Jalal Tommy Pallett Fuad Mosis Ahmad Guni Simon Brayford Lawrence Yolland Stefania Marcotti James A. Levitt Simon P. Poland Maia Rowe-Sampson Anett Jandke Robert Köchl Giordano Pula Simon M. Ameer-Beg Brian Marc Stramer Matthias Krause Nance-Horan Syndrome-like 1 protein negatively regulates Scar/WAVE-Arp2/3 activity and inhibits lamellipodia stability and cell migration
description	Cell migration is essential for many physiological processes. Its deregulation causes cancer metastasis and it is not well understood how it is tightly controlled. We identify NHSL1 as a negative regulator of actin nucleating Scar/WAVE-Arp2/3 complexes, cell protrusion stability, and cell migration.
format	article
author	Ah-Lai Law Shamsinar Jalal Tommy Pallett Fuad Mosis Ahmad Guni Simon Brayford Lawrence Yolland Stefania Marcotti James A. Levitt Simon P. Poland Maia Rowe-Sampson Anett Jandke Robert Köchl Giordano Pula Simon M. Ameer-Beg Brian Marc Stramer Matthias Krause
author_facet	Ah-Lai Law Shamsinar Jalal Tommy Pallett Fuad Mosis Ahmad Guni Simon Brayford Lawrence Yolland Stefania Marcotti James A. Levitt Simon P. Poland Maia Rowe-Sampson Anett Jandke Robert Köchl Giordano Pula Simon M. Ameer-Beg Brian Marc Stramer Matthias Krause
author_sort	Ah-Lai Law
title	Nance-Horan Syndrome-like 1 protein negatively regulates Scar/WAVE-Arp2/3 activity and inhibits lamellipodia stability and cell migration
title_short	Nance-Horan Syndrome-like 1 protein negatively regulates Scar/WAVE-Arp2/3 activity and inhibits lamellipodia stability and cell migration
title_full	Nance-Horan Syndrome-like 1 protein negatively regulates Scar/WAVE-Arp2/3 activity and inhibits lamellipodia stability and cell migration
title_fullStr	Nance-Horan Syndrome-like 1 protein negatively regulates Scar/WAVE-Arp2/3 activity and inhibits lamellipodia stability and cell migration
title_full_unstemmed	Nance-Horan Syndrome-like 1 protein negatively regulates Scar/WAVE-Arp2/3 activity and inhibits lamellipodia stability and cell migration
title_sort	nance-horan syndrome-like 1 protein negatively regulates scar/wave-arp2/3 activity and inhibits lamellipodia stability and cell migration
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5f81f0f7930346ea95298ce9f59b6d60
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Nance-Horan Syndrome-like 1 protein negatively regulates Scar/WAVE-Arp2/3 activity and inhibits lamellipodia stability and cell migration

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