Staphylococcus aureus lipoproteins promote abscess formation in mice, shielding bacteria from immune killing

Mohammad et al. show that subcutaneous injection of Staphylococcus aureus lipoproteins (Lpp) leads to the infiltration of neutrophils and monocytes/macrophages, inducing skin lesions in mice. They find that S. aureus Lpp promotes abscess formation, which protects bacteria from innate immune killing,...

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Autores principales:	Majd Mohammad, Manli Na, Zhicheng Hu, Minh-Thu Nguyen, Pradeep Kumar Kopparapu, Anders Jarneborn, Anna Karlsson, Abukar Ali, Rille Pullerits, Friedrich Götz, Tao Jin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5f86a771da2a4034989658dbfdd8a8f5
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spelling	oai:doaj.org-article:5f86a771da2a4034989658dbfdd8a8f52021-12-02T14:23:32ZStaphylococcus aureus lipoproteins promote abscess formation in mice, shielding bacteria from immune killing10.1038/s42003-021-01947-z2399-3642https://doaj.org/article/5f86a771da2a4034989658dbfdd8a8f52021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01947-zhttps://doaj.org/toc/2399-3642Mohammad et al. show that subcutaneous injection of Staphylococcus aureus lipoproteins (Lpp) leads to the infiltration of neutrophils and monocytes/macrophages, inducing skin lesions in mice. They find that S. aureus Lpp promotes abscess formation, which protects bacteria from innate immune killing, suggesting an intriguing bacterial immune evasion mechanism.Majd MohammadManli NaZhicheng HuMinh-Thu NguyenPradeep Kumar KopparapuAnders JarnebornAnna KarlssonAbukar AliRille PulleritsFriedrich GötzTao JinNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Majd Mohammad Manli Na Zhicheng Hu Minh-Thu Nguyen Pradeep Kumar Kopparapu Anders Jarneborn Anna Karlsson Abukar Ali Rille Pullerits Friedrich Götz Tao Jin Staphylococcus aureus lipoproteins promote abscess formation in mice, shielding bacteria from immune killing
description	Mohammad et al. show that subcutaneous injection of Staphylococcus aureus lipoproteins (Lpp) leads to the infiltration of neutrophils and monocytes/macrophages, inducing skin lesions in mice. They find that S. aureus Lpp promotes abscess formation, which protects bacteria from innate immune killing, suggesting an intriguing bacterial immune evasion mechanism.
format	article
author	Majd Mohammad Manli Na Zhicheng Hu Minh-Thu Nguyen Pradeep Kumar Kopparapu Anders Jarneborn Anna Karlsson Abukar Ali Rille Pullerits Friedrich Götz Tao Jin
author_facet	Majd Mohammad Manli Na Zhicheng Hu Minh-Thu Nguyen Pradeep Kumar Kopparapu Anders Jarneborn Anna Karlsson Abukar Ali Rille Pullerits Friedrich Götz Tao Jin
author_sort	Majd Mohammad
title	Staphylococcus aureus lipoproteins promote abscess formation in mice, shielding bacteria from immune killing
title_short	Staphylococcus aureus lipoproteins promote abscess formation in mice, shielding bacteria from immune killing
title_full	Staphylococcus aureus lipoproteins promote abscess formation in mice, shielding bacteria from immune killing
title_fullStr	Staphylococcus aureus lipoproteins promote abscess formation in mice, shielding bacteria from immune killing
title_full_unstemmed	Staphylococcus aureus lipoproteins promote abscess formation in mice, shielding bacteria from immune killing
title_sort	staphylococcus aureus lipoproteins promote abscess formation in mice, shielding bacteria from immune killing
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5f86a771da2a4034989658dbfdd8a8f5
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Staphylococcus aureus lipoproteins promote abscess formation in mice, shielding bacteria from immune killing

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