Stem cells and the origin of gliomas: A historical reappraisal with molecular advancements

Michael L Levy1, Allen L Ho1,2, Samuel Hughes3, Jayant Menon1, Rahul Jandial41Division of Neurosurgery, University of California, San Diego, La Jolla, California, USA; 2Del E Webb Neurosciences, Aging and Stem Cell Research Center, The Burnham Institute for Medical Research, La Jolla, California, US...

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Autores principales:	Michael L Levy, Allen L Ho, Samuel Hughes, Jayant Menon, Rahul Jandial
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/5f8851a78187440c993a34c8d08b7ea4
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spelling	oai:doaj.org-article:5f8851a78187440c993a34c8d08b7ea42021-12-02T01:00:04ZStem cells and the origin of gliomas: A historical reappraisal with molecular advancements1178-6957https://doaj.org/article/5f8851a78187440c993a34c8d08b7ea42009-01-01T00:00:00Zhttp://www.dovepress.com/stem-cells-and-the-origin-of-gliomas-a-historical-reappraisal-with-mol-a2799https://doaj.org/toc/1178-6957Michael L Levy1, Allen L Ho1,2, Samuel Hughes3, Jayant Menon1, Rahul Jandial41Division of Neurosurgery, University of California, San Diego, La Jolla, California, USA; 2Del E Webb Neurosciences, Aging and Stem Cell Research Center, The Burnham Institute for Medical Research, La Jolla, California, USA; 3Department of Neurological Surgery, Oregon Health and Science University, Portland, OR, USA; 4Division of Neurosurgery, Department of Surgery, City of Hope Cancer Center, Duarte, CA, USAAbstract: The biology of both normal and tumor development clearly possesses overlapping and parallel features. Oncogenes and tumor suppressors are relevant not only in tumor biology, but also in physiological developmental regulators of growth and differentiation. Conversely, genes identified as regulators of developmental biology are relevant to tumor biology. This is particularly relevant in the context of brain tumors, where recent evidence is mounting that the origin of brain tumors, specifically gliomas, may represent dysfunctional developmental neurobiology. Neural stem cells are increasingly being investigated as the cell type that originally undergoes malignant transformation &ndash; the cell of origin &ndash; and the evidence for this is discussed.Keywords: stem cells, gliomas, neural stem cells, brain tumors, cancer stem cells Michael L LevyAllen L HoSamuel HughesJayant MenonRahul JandialDove Medical PressarticleCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol 2008, Iss default, Pp 41-47 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Michael L Levy Allen L Ho Samuel Hughes Jayant Menon Rahul Jandial Stem cells and the origin of gliomas: A historical reappraisal with molecular advancements
description	Michael L Levy1, Allen L Ho1,2, Samuel Hughes3, Jayant Menon1, Rahul Jandial41Division of Neurosurgery, University of California, San Diego, La Jolla, California, USA; 2Del E Webb Neurosciences, Aging and Stem Cell Research Center, The Burnham Institute for Medical Research, La Jolla, California, USA; 3Department of Neurological Surgery, Oregon Health and Science University, Portland, OR, USA; 4Division of Neurosurgery, Department of Surgery, City of Hope Cancer Center, Duarte, CA, USAAbstract: The biology of both normal and tumor development clearly possesses overlapping and parallel features. Oncogenes and tumor suppressors are relevant not only in tumor biology, but also in physiological developmental regulators of growth and differentiation. Conversely, genes identified as regulators of developmental biology are relevant to tumor biology. This is particularly relevant in the context of brain tumors, where recent evidence is mounting that the origin of brain tumors, specifically gliomas, may represent dysfunctional developmental neurobiology. Neural stem cells are increasingly being investigated as the cell type that originally undergoes malignant transformation &ndash; the cell of origin &ndash; and the evidence for this is discussed.Keywords: stem cells, gliomas, neural stem cells, brain tumors, cancer stem cells
format	article
author	Michael L Levy Allen L Ho Samuel Hughes Jayant Menon Rahul Jandial
author_facet	Michael L Levy Allen L Ho Samuel Hughes Jayant Menon Rahul Jandial
author_sort	Michael L Levy
title	Stem cells and the origin of gliomas: A historical reappraisal with molecular advancements
title_short	Stem cells and the origin of gliomas: A historical reappraisal with molecular advancements
title_full	Stem cells and the origin of gliomas: A historical reappraisal with molecular advancements
title_fullStr	Stem cells and the origin of gliomas: A historical reappraisal with molecular advancements
title_full_unstemmed	Stem cells and the origin of gliomas: A historical reappraisal with molecular advancements
title_sort	stem cells and the origin of gliomas: a historical reappraisal with molecular advancements
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/5f8851a78187440c993a34c8d08b7ea4
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Stem cells and the origin of gliomas: A historical reappraisal with molecular advancements

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