Effect of Successful Direct Acting Antivirals Therapy on Liver Stiffness in Patients with Chronic HCV Infection

Background: Achievement of sustained virological response [SVR] and improvement of hepatic fibrosis are the essential goals for therapy of chronic hepatitis C [CHC] with direct acting antivirals [DAAs] therapy. Early detection and management of hepatic fibrosis can significantly improve the prognosi...

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Autores principales:	Ibrahim Anam Ezzelregal, Fathya Mostafa Elraie, Khalid Elmola, Mostafa Mohamed Shaqueer
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2020
Materias:	direct acting antivirals elastography hepatitis c virus liver fibrosis sustained virological response Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5f91c58e0404426980b546aa7545d7b8
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spelling	oai:doaj.org-article:5f91c58e0404426980b546aa7545d7b82021-12-02T14:02:00ZEffect of Successful Direct Acting Antivirals Therapy on Liver Stiffness in Patients with Chronic HCV Infection2636-41742682-378010.21608/ijma.2020.23053.1138https://doaj.org/article/5f91c58e0404426980b546aa7545d7b82020-10-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_112847_4cb0572fa072b3af238564cbc8a8b198.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: Achievement of sustained virological response [SVR] and improvement of hepatic fibrosis are the essential goals for therapy of chronic hepatitis C [CHC] with direct acting antivirals [DAAs] therapy. Early detection and management of hepatic fibrosis can significantly improve the prognosis of CHC in clinical practice. Aim of the work: To assess the effect of successful DAAs therapy on liver stiffness in patients with CHC. Methods: This study included 100 patients with chronic HCV-related liver disease. All were treated with Sofosbuvir-based regimen for 12 weeks on outpatient base. HCV treatment applied according to the protocol designed by the Egyptian National Committee for Control of Viral Hepatitis. Follow up continued for 12 weeks [after the end of treatment [EOT]] to estimate effect of successful DAAS therapy on liver stiffness using Shear Wave Elastography [SWE], aminotransferase-to platelet ratio index [APRI] and Fib-4 score before initiation of antiviral therapy, at end of treatment [EOT] and 12 weeks after EOT [SVR12]. Results: Platelets significantly increased, ALT and AST decreased and mean values of APRI, Fib-4 score and Liver stiffness assessment were significantly reduced in all patients at SVR12. Hemoglobin levels significantly reduced in patients receiving ribavirin 12 weeks after EOT. Conclusions: Elimination of HCV after successful DAAS treatment was associated with a significant improvement of the liver stiffness at both EOT and 12 weeks afterwards EOT as evidenced by SWE, Fib-4 score and APRI indexIbrahim Anam EzzelregalFathya Mostafa ElraieKhalid ElmolaMostafa Mohamed ShaqueerAl-Azhar University, Faculty of Medicine (Damietta)articledirect acting antiviralselastographyhepatitis c virusliver fibrosissustained virological responseMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 2, Iss 4, Pp 854-859 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	direct acting antivirals elastography hepatitis c virus liver fibrosis sustained virological response Medicine (General) R5-920
spellingShingle	direct acting antivirals elastography hepatitis c virus liver fibrosis sustained virological response Medicine (General) R5-920 Ibrahim Anam Ezzelregal Fathya Mostafa Elraie Khalid Elmola Mostafa Mohamed Shaqueer Effect of Successful Direct Acting Antivirals Therapy on Liver Stiffness in Patients with Chronic HCV Infection
description	Background: Achievement of sustained virological response [SVR] and improvement of hepatic fibrosis are the essential goals for therapy of chronic hepatitis C [CHC] with direct acting antivirals [DAAs] therapy. Early detection and management of hepatic fibrosis can significantly improve the prognosis of CHC in clinical practice. Aim of the work: To assess the effect of successful DAAs therapy on liver stiffness in patients with CHC. Methods: This study included 100 patients with chronic HCV-related liver disease. All were treated with Sofosbuvir-based regimen for 12 weeks on outpatient base. HCV treatment applied according to the protocol designed by the Egyptian National Committee for Control of Viral Hepatitis. Follow up continued for 12 weeks [after the end of treatment [EOT]] to estimate effect of successful DAAS therapy on liver stiffness using Shear Wave Elastography [SWE], aminotransferase-to platelet ratio index [APRI] and Fib-4 score before initiation of antiviral therapy, at end of treatment [EOT] and 12 weeks after EOT [SVR12]. Results: Platelets significantly increased, ALT and AST decreased and mean values of APRI, Fib-4 score and Liver stiffness assessment were significantly reduced in all patients at SVR12. Hemoglobin levels significantly reduced in patients receiving ribavirin 12 weeks after EOT. Conclusions: Elimination of HCV after successful DAAS treatment was associated with a significant improvement of the liver stiffness at both EOT and 12 weeks afterwards EOT as evidenced by SWE, Fib-4 score and APRI index
format	article
author	Ibrahim Anam Ezzelregal Fathya Mostafa Elraie Khalid Elmola Mostafa Mohamed Shaqueer
author_facet	Ibrahim Anam Ezzelregal Fathya Mostafa Elraie Khalid Elmola Mostafa Mohamed Shaqueer
author_sort	Ibrahim Anam Ezzelregal
title	Effect of Successful Direct Acting Antivirals Therapy on Liver Stiffness in Patients with Chronic HCV Infection
title_short	Effect of Successful Direct Acting Antivirals Therapy on Liver Stiffness in Patients with Chronic HCV Infection
title_full	Effect of Successful Direct Acting Antivirals Therapy on Liver Stiffness in Patients with Chronic HCV Infection
title_fullStr	Effect of Successful Direct Acting Antivirals Therapy on Liver Stiffness in Patients with Chronic HCV Infection
title_full_unstemmed	Effect of Successful Direct Acting Antivirals Therapy on Liver Stiffness in Patients with Chronic HCV Infection
title_sort	effect of successful direct acting antivirals therapy on liver stiffness in patients with chronic hcv infection
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2020
url	https://doaj.org/article/5f91c58e0404426980b546aa7545d7b8
work_keys_str_mv	AT ibrahimanamezzelregal effectofsuccessfuldirectactingantiviralstherapyonliverstiffnessinpatientswithchronichcvinfection AT fathyamostafaelraie effectofsuccessfuldirectactingantiviralstherapyonliverstiffnessinpatientswithchronichcvinfection AT khalidelmola effectofsuccessfuldirectactingantiviralstherapyonliverstiffnessinpatientswithchronichcvinfection AT mostafamohamedshaqueer effectofsuccessfuldirectactingantiviralstherapyonliverstiffnessinpatientswithchronichcvinfection
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Effect of Successful Direct Acting Antivirals Therapy on Liver Stiffness in Patients with Chronic HCV Infection

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