The status of serum cortisol before and after treatment of schizophrenia and its correlation to disease severity and improvement: A longitudinal study

Background: Hypothalamic–pituitary–adrenal axis functioning, with cortisol as its major output hormone, has been presumed to play a key role in the development of psychopathology of schizophrenia. Objective: We examined the association of serum cortisol with disease severity and improvement in schiz...

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Autores principales:	Yohannes Markos Woldesenbet, Arefayne Alenko, Iyasu Tadesse Bukata, Lealem Gedefaw, Chaltu Fikru
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5f92d456841d40d584d4add3ccc3f252
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spelling	oai:doaj.org-article:5f92d456841d40d584d4add3ccc3f2522021-11-09T23:03:56ZThe status of serum cortisol before and after treatment of schizophrenia and its correlation to disease severity and improvement: A longitudinal study2050-312110.1177/20503121211056216https://doaj.org/article/5f92d456841d40d584d4add3ccc3f2522021-11-01T00:00:00Zhttps://doi.org/10.1177/20503121211056216https://doaj.org/toc/2050-3121Background: Hypothalamic–pituitary–adrenal axis functioning, with cortisol as its major output hormone, has been presumed to play a key role in the development of psychopathology of schizophrenia. Objective: We examined the association of serum cortisol with disease severity and improvement in schizophrenia patients in Jimma, Ethiopia. Method: A total of 34 newly diagnosed schizophrenics were included in this study. Data on demographic, behavioral, clinical state, serum cholesterol level, and antipsychotic usage were obtained at baseline and after 8 weeks. The Positive and Negative Syndrome Scale was used to assess psychotic symptoms severity. A paired sample t -test was used to compare baseline and post-treatment values. Linear regression was used to assess associations. Result: Post-treatment serum cortisol level was significantly lower than its baseline value ( p = 0.001). There was also a significant positive and negative psychotic symptoms decrease after treatment (baseline positive psychotic vs post-treatment positive psychotic symptoms: t (33) = 6.24 (95% confidence interval = 7.03,13.84, p = 0.000) and (baseline negative psychotic vs post-treatment negative psychotic symptoms: t (33) = 4.21 (95% confidence interval = 3.82, 10.99, p = 0.000). At baseline, neither positive nor negative subscore on the Positive and Negative Syndrome Scale showed an association with serum cortisol level ( B = −0.016, p = 0.794 and B = −0.032, p = 0.594). However, serum cortisol level showed strong associations with post-treatment positive sub scores and negative sub scores ( B = 0.167, p = 0.007) and ( B = 0.144, p = 0.010) on the Positive and Negative Syndrome Scale. Conclusion: We found a significant decrease in serum cortisol level after antipsychotics treatment and that was associated with improvement in psychotic symptoms in schizophrenics in Jimma, Ethiopia.Yohannes Markos WoldesenbetArefayne AlenkoIyasu Tadesse BukataLealem GedefawChaltu FikruSAGE PublishingarticleMedicine (General)R5-920ENSAGE Open Medicine, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Yohannes Markos Woldesenbet Arefayne Alenko Iyasu Tadesse Bukata Lealem Gedefaw Chaltu Fikru The status of serum cortisol before and after treatment of schizophrenia and its correlation to disease severity and improvement: A longitudinal study
description	Background: Hypothalamic–pituitary–adrenal axis functioning, with cortisol as its major output hormone, has been presumed to play a key role in the development of psychopathology of schizophrenia. Objective: We examined the association of serum cortisol with disease severity and improvement in schizophrenia patients in Jimma, Ethiopia. Method: A total of 34 newly diagnosed schizophrenics were included in this study. Data on demographic, behavioral, clinical state, serum cholesterol level, and antipsychotic usage were obtained at baseline and after 8 weeks. The Positive and Negative Syndrome Scale was used to assess psychotic symptoms severity. A paired sample t -test was used to compare baseline and post-treatment values. Linear regression was used to assess associations. Result: Post-treatment serum cortisol level was significantly lower than its baseline value ( p = 0.001). There was also a significant positive and negative psychotic symptoms decrease after treatment (baseline positive psychotic vs post-treatment positive psychotic symptoms: t (33) = 6.24 (95% confidence interval = 7.03,13.84, p = 0.000) and (baseline negative psychotic vs post-treatment negative psychotic symptoms: t (33) = 4.21 (95% confidence interval = 3.82, 10.99, p = 0.000). At baseline, neither positive nor negative subscore on the Positive and Negative Syndrome Scale showed an association with serum cortisol level ( B = −0.016, p = 0.794 and B = −0.032, p = 0.594). However, serum cortisol level showed strong associations with post-treatment positive sub scores and negative sub scores ( B = 0.167, p = 0.007) and ( B = 0.144, p = 0.010) on the Positive and Negative Syndrome Scale. Conclusion: We found a significant decrease in serum cortisol level after antipsychotics treatment and that was associated with improvement in psychotic symptoms in schizophrenics in Jimma, Ethiopia.
format	article
author	Yohannes Markos Woldesenbet Arefayne Alenko Iyasu Tadesse Bukata Lealem Gedefaw Chaltu Fikru
author_facet	Yohannes Markos Woldesenbet Arefayne Alenko Iyasu Tadesse Bukata Lealem Gedefaw Chaltu Fikru
author_sort	Yohannes Markos Woldesenbet
title	The status of serum cortisol before and after treatment of schizophrenia and its correlation to disease severity and improvement: A longitudinal study
title_short	The status of serum cortisol before and after treatment of schizophrenia and its correlation to disease severity and improvement: A longitudinal study
title_full	The status of serum cortisol before and after treatment of schizophrenia and its correlation to disease severity and improvement: A longitudinal study
title_fullStr	The status of serum cortisol before and after treatment of schizophrenia and its correlation to disease severity and improvement: A longitudinal study
title_full_unstemmed	The status of serum cortisol before and after treatment of schizophrenia and its correlation to disease severity and improvement: A longitudinal study
title_sort	status of serum cortisol before and after treatment of schizophrenia and its correlation to disease severity and improvement: a longitudinal study
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/5f92d456841d40d584d4add3ccc3f252
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The status of serum cortisol before and after treatment of schizophrenia and its correlation to disease severity and improvement: A longitudinal study

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