KCNQ1OT1: An Oncogenic Long Noncoding RNA

Long noncoding RNAs (lncRNAs) are transcripts greater than 200 nucleotides that do not code for proteins but regulate gene expression. Recent studies indicate that lncRNAs are involved in the modulation of biological functions in human disease. KCNQ1 Opposite Strand/Antisense Transcript 1 (KCNQ1OT1)...

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Autores principales:	Patrice Cagle, Qi Qi, Suryakant Niture, Deepak Kumar
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	human cancers competing endogenous RNA long noncoding RNA KCNQ1OT1 Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/5f933384ae18494f92436fb08e6b7bed
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spelling	oai:doaj.org-article:5f933384ae18494f92436fb08e6b7bed2021-11-25T16:52:42ZKCNQ1OT1: An Oncogenic Long Noncoding RNA10.3390/biom111116022218-273Xhttps://doaj.org/article/5f933384ae18494f92436fb08e6b7bed2021-10-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1602https://doaj.org/toc/2218-273XLong noncoding RNAs (lncRNAs) are transcripts greater than 200 nucleotides that do not code for proteins but regulate gene expression. Recent studies indicate that lncRNAs are involved in the modulation of biological functions in human disease. KCNQ1 Opposite Strand/Antisense Transcript 1 (KCNQ1OT1) encodes a lncRNA from the opposite strand of KCNQ1 in the CDKN1C/KCNQ1OT1 cluster that is reported to play a vital role in the development and progression of cancer. KCNQ1OT1 regulates cancer cell proliferation, cell cycle, migration and invasion, metastasis, glucose metabolism, and immune evasion. The aberrant expression of KCNQ1OT1 in cancer patients is associated with poor prognosis and decreased survival. This review summarizes recent literature related to the biological functions and molecular mechanisms of KCNQ1OT1 in various human cancers, including colorectal, bladder, breast, oral, melanoma, osteosarcoma, lung, glioma, ovarian, liver, acute myeloid leukemia, prostate, and gastric. We also discuss the role of KCNQ1OT1 as a promising diagnostic biomarker and a novel therapeutic target in human cancers.Patrice CagleQi QiSuryakant NitureDeepak KumarMDPI AGarticlehuman cancerscompeting endogenous RNAlong noncoding RNAKCNQ1OT1MicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1602, p 1602 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	human cancers competing endogenous RNA long noncoding RNA KCNQ1OT1 Microbiology QR1-502
spellingShingle	human cancers competing endogenous RNA long noncoding RNA KCNQ1OT1 Microbiology QR1-502 Patrice Cagle Qi Qi Suryakant Niture Deepak Kumar KCNQ1OT1: An Oncogenic Long Noncoding RNA
description	Long noncoding RNAs (lncRNAs) are transcripts greater than 200 nucleotides that do not code for proteins but regulate gene expression. Recent studies indicate that lncRNAs are involved in the modulation of biological functions in human disease. KCNQ1 Opposite Strand/Antisense Transcript 1 (KCNQ1OT1) encodes a lncRNA from the opposite strand of KCNQ1 in the CDKN1C/KCNQ1OT1 cluster that is reported to play a vital role in the development and progression of cancer. KCNQ1OT1 regulates cancer cell proliferation, cell cycle, migration and invasion, metastasis, glucose metabolism, and immune evasion. The aberrant expression of KCNQ1OT1 in cancer patients is associated with poor prognosis and decreased survival. This review summarizes recent literature related to the biological functions and molecular mechanisms of KCNQ1OT1 in various human cancers, including colorectal, bladder, breast, oral, melanoma, osteosarcoma, lung, glioma, ovarian, liver, acute myeloid leukemia, prostate, and gastric. We also discuss the role of KCNQ1OT1 as a promising diagnostic biomarker and a novel therapeutic target in human cancers.
format	article
author	Patrice Cagle Qi Qi Suryakant Niture Deepak Kumar
author_facet	Patrice Cagle Qi Qi Suryakant Niture Deepak Kumar
author_sort	Patrice Cagle
title	KCNQ1OT1: An Oncogenic Long Noncoding RNA
title_short	KCNQ1OT1: An Oncogenic Long Noncoding RNA
title_full	KCNQ1OT1: An Oncogenic Long Noncoding RNA
title_fullStr	KCNQ1OT1: An Oncogenic Long Noncoding RNA
title_full_unstemmed	KCNQ1OT1: An Oncogenic Long Noncoding RNA
title_sort	kcnq1ot1: an oncogenic long noncoding rna
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5f933384ae18494f92436fb08e6b7bed
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_version_	1718412898962767872

KCNQ1OT1: An Oncogenic Long Noncoding RNA

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