Enhancing attention in neurodegenerative diseases: current therapies and future directions

We all experience at least occasional lapses in attention but in some neurological conditions, loss of attention is pervasive and debilitating. Treating deficits in attention first requires an understanding of the neurobiology of attention, which we now understand to be a set of different cognitive...

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Autores principales:	Sharma Kanchan, Davis Thomas, Coulthard Elizabeth
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2016
Materias:	alerting network attention network caffeine executive network meditation neurodegeneration Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/5f93a0a1736f4375834b571db11aa1cf
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spelling	oai:doaj.org-article:5f93a0a1736f4375834b571db11aa1cf2021-12-05T14:11:04ZEnhancing attention in neurodegenerative diseases: current therapies and future directions2081-693610.1515/tnsci-2016-0016https://doaj.org/article/5f93a0a1736f4375834b571db11aa1cf2016-01-01T00:00:00Zhttps://doi.org/10.1515/tnsci-2016-0016https://doaj.org/toc/2081-6936We all experience at least occasional lapses in attention but in some neurological conditions, loss of attention is pervasive and debilitating. Treating deficits in attention first requires an understanding of the neurobiology of attention, which we now understand to be a set of different cognitive processes. Cholinesterase inhibitors are already established as effective attentional enhancers used in the treatment of certain dementias. Other stimulant agents such as modafanil, amphetamine and methylphenidate have demonstrated limited success in healthy individuals where attention is already optimal and clinical trials in patients with neurological disease are sparse. Dietary and lifestyle changes are gaining increasing prominence, as are experimental treatments such as deep brain stimulation and transcranial magnetic stimulation. As the therapeutic arsenal widens, clinicians will be able to match specific treatments to selective deficits in attention, giving patients a tailored management plan. Here we review common diseases that impair attention and emphasise how an understanding of attentional processing within the brain might lead to improved therapeutic strategies.Sharma KanchanDavis ThomasCoulthard ElizabethDe Gruyterarticlealerting networkattention networkcaffeineexecutive networkmeditationneurodegenerationNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Neuroscience, Vol 7, Iss 1, Pp 98-109 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	alerting network attention network caffeine executive network meditation neurodegeneration Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	alerting network attention network caffeine executive network meditation neurodegeneration Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Sharma Kanchan Davis Thomas Coulthard Elizabeth Enhancing attention in neurodegenerative diseases: current therapies and future directions
description	We all experience at least occasional lapses in attention but in some neurological conditions, loss of attention is pervasive and debilitating. Treating deficits in attention first requires an understanding of the neurobiology of attention, which we now understand to be a set of different cognitive processes. Cholinesterase inhibitors are already established as effective attentional enhancers used in the treatment of certain dementias. Other stimulant agents such as modafanil, amphetamine and methylphenidate have demonstrated limited success in healthy individuals where attention is already optimal and clinical trials in patients with neurological disease are sparse. Dietary and lifestyle changes are gaining increasing prominence, as are experimental treatments such as deep brain stimulation and transcranial magnetic stimulation. As the therapeutic arsenal widens, clinicians will be able to match specific treatments to selective deficits in attention, giving patients a tailored management plan. Here we review common diseases that impair attention and emphasise how an understanding of attentional processing within the brain might lead to improved therapeutic strategies.
format	article
author	Sharma Kanchan Davis Thomas Coulthard Elizabeth
author_facet	Sharma Kanchan Davis Thomas Coulthard Elizabeth
author_sort	Sharma Kanchan
title	Enhancing attention in neurodegenerative diseases: current therapies and future directions
title_short	Enhancing attention in neurodegenerative diseases: current therapies and future directions
title_full	Enhancing attention in neurodegenerative diseases: current therapies and future directions
title_fullStr	Enhancing attention in neurodegenerative diseases: current therapies and future directions
title_full_unstemmed	Enhancing attention in neurodegenerative diseases: current therapies and future directions
title_sort	enhancing attention in neurodegenerative diseases: current therapies and future directions
publisher	De Gruyter
publishDate	2016
url	https://doaj.org/article/5f93a0a1736f4375834b571db11aa1cf
work_keys_str_mv	AT sharmakanchan enhancingattentioninneurodegenerativediseasescurrenttherapiesandfuturedirections AT davisthomas enhancingattentioninneurodegenerativediseasescurrenttherapiesandfuturedirections AT coulthardelizabeth enhancingattentioninneurodegenerativediseasescurrenttherapiesandfuturedirections
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Enhancing attention in neurodegenerative diseases: current therapies and future directions

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