A living biobank of ovarian cancer ex vivo models reveals profound mitotic heterogeneity
High-grade serous ovarian carcinoma is often associated with TP53 mutation and chromosomal instability (CIN). Here, the authors generate ex vivo cultures from biopsies and ascites of patients and perform characterization to evaluate CIN mechanisms and compare drug sensitivity with patient responses.
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Nature Portfolio
2020
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oai:doaj.org-article:5f96b03935524c6e8d18bbc5878047b42021-12-02T15:39:12ZA living biobank of ovarian cancer ex vivo models reveals profound mitotic heterogeneity10.1038/s41467-020-14551-22041-1723https://doaj.org/article/5f96b03935524c6e8d18bbc5878047b42020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14551-2https://doaj.org/toc/2041-1723High-grade serous ovarian carcinoma is often associated with TP53 mutation and chromosomal instability (CIN). Here, the authors generate ex vivo cultures from biopsies and ascites of patients and perform characterization to evaluate CIN mechanisms and compare drug sensitivity with patient responses.Louisa NelsonAnthony TigheAnya GolderSamantha LittlerBjorn BakkerDaniela MoralliSyed Murtuza BakerIan J. DonaldsonDiana C. J. SpieringsRené WardenaarBethanie NealeGeorge J. BurghelBrett Winter-RoachRichard EdmondsonAndrew R. ClampGordon C. JaysonSudha DesaiCatherine M. GreenAndy HayesFloris FoijerRobert D. MorganStephen S. TaylorNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Louisa Nelson Anthony Tighe Anya Golder Samantha Littler Bjorn Bakker Daniela Moralli Syed Murtuza Baker Ian J. Donaldson Diana C. J. Spierings René Wardenaar Bethanie Neale George J. Burghel Brett Winter-Roach Richard Edmondson Andrew R. Clamp Gordon C. Jayson Sudha Desai Catherine M. Green Andy Hayes Floris Foijer Robert D. Morgan Stephen S. Taylor A living biobank of ovarian cancer ex vivo models reveals profound mitotic heterogeneity |
| description |
High-grade serous ovarian carcinoma is often associated with TP53 mutation and chromosomal instability (CIN). Here, the authors generate ex vivo cultures from biopsies and ascites of patients and perform characterization to evaluate CIN mechanisms and compare drug sensitivity with patient responses. |
| format |
article |
| author |
Louisa Nelson Anthony Tighe Anya Golder Samantha Littler Bjorn Bakker Daniela Moralli Syed Murtuza Baker Ian J. Donaldson Diana C. J. Spierings René Wardenaar Bethanie Neale George J. Burghel Brett Winter-Roach Richard Edmondson Andrew R. Clamp Gordon C. Jayson Sudha Desai Catherine M. Green Andy Hayes Floris Foijer Robert D. Morgan Stephen S. Taylor |
| author_facet |
Louisa Nelson Anthony Tighe Anya Golder Samantha Littler Bjorn Bakker Daniela Moralli Syed Murtuza Baker Ian J. Donaldson Diana C. J. Spierings René Wardenaar Bethanie Neale George J. Burghel Brett Winter-Roach Richard Edmondson Andrew R. Clamp Gordon C. Jayson Sudha Desai Catherine M. Green Andy Hayes Floris Foijer Robert D. Morgan Stephen S. Taylor |
| author_sort |
Louisa Nelson |
| title |
A living biobank of ovarian cancer ex vivo models reveals profound mitotic heterogeneity |
| title_short |
A living biobank of ovarian cancer ex vivo models reveals profound mitotic heterogeneity |
| title_full |
A living biobank of ovarian cancer ex vivo models reveals profound mitotic heterogeneity |
| title_fullStr |
A living biobank of ovarian cancer ex vivo models reveals profound mitotic heterogeneity |
| title_full_unstemmed |
A living biobank of ovarian cancer ex vivo models reveals profound mitotic heterogeneity |
| title_sort |
living biobank of ovarian cancer ex vivo models reveals profound mitotic heterogeneity |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/5f96b03935524c6e8d18bbc5878047b4 |
| work_keys_str_mv |
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