A case of sebaceous adenoma of the eyelid showing excessively rapid growth
Kei Takayama,1 Yoshihiko Usui,2 Masataka Ito,3 Hiroshi Goto,2 Masaru Takeuchi1 1Department of Ophthalmology, National Defense Medical College, Tokorozawa, Saitama, Japan; 2Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan; 3Department of Developmental Anatomy and Regenerative Biolo...
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Dove Medical Press
2013
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oai:doaj.org-article:5f97aeda42c34d108732946a843ee5742021-12-02T02:07:54ZA case of sebaceous adenoma of the eyelid showing excessively rapid growth1177-54671177-5483https://doaj.org/article/5f97aeda42c34d108732946a843ee5742013-04-01T00:00:00Zhttp://www.dovepress.com/a-case-of-sebaceous-adenoma-of-the-eyelid-showing-excessively-rapid-gr-a12640https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Kei Takayama,1 Yoshihiko Usui,2 Masataka Ito,3 Hiroshi Goto,2 Masaru Takeuchi1 1Department of Ophthalmology, National Defense Medical College, Tokorozawa, Saitama, Japan; 2Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan; 3Department of Developmental Anatomy and Regenerative Biology, National Defense Medical College, Tokorozawa, Saitama, Japan Background: Sebaceous adenomas are found mainly in elderly individuals and are usually tan, pink, or yellow nodules or papules, usually approximately 5 mm in the largest size. Case report: A 65-year-old man presented with a progressively enlarging exophytic lesion in the right eyelid for 3 months. External examination revealed a yellowish-pink growth measuring 18 × 13 × 14 mm. The lesion surface was covered by palpebral conjunctiva with fine papillary projections, vascularity, crusting, and ulceration. Two weeks later, the growth enlarged to 20 × 14 × 14 mm, and ulceration also expanded. An excisional biopsy with clear resection margins was performed. No malignancy was found in the stump. Histopathologically, the lesion was located principally within the cutaneous compartment and composed of multiple circumscribed sebaceous lobules, separated, and exhibiting no cytologic atypia. Cystic change was not evident, and no infiltrative growth pattern, pagetoid lesions, mitotic figures, and lymphovascular space invasion were observed. The Ki-67 nuclear antigen was detected in 10%–15% of cells located in the basal zone of the nodule. Fluorescence in situ hybridization showed low human epidermal growth factor receptor 2 amplification, suggesting no genetic changes. The clinical findings, lack of infiltrative border, low Ki-67 index, and low proliferative ability support a diagnosis of sebaceous adenoma. Conclusion: Sebaceous adenoma that shows excessively rapid growth due to hyperplasia may appear to be malignant. Histopathology, fluorescence in situ hybridization, and Ki-67 were useful to the diagnosis of the adenoma. Excisional biopsy with clear resection margins must be performed in rapidly growing tumors. Keywords: sebaceous adenoma, Ki-67, fluorescence in situ hybridization, sebaceous carcinomaTakayama KUsui YIto MGoto HTakeuchi MDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 667-670 (2013) |
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Ophthalmology RE1-994 |
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Ophthalmology RE1-994 Takayama K Usui Y Ito M Goto H Takeuchi M A case of sebaceous adenoma of the eyelid showing excessively rapid growth |
| description |
Kei Takayama,1 Yoshihiko Usui,2 Masataka Ito,3 Hiroshi Goto,2 Masaru Takeuchi1 1Department of Ophthalmology, National Defense Medical College, Tokorozawa, Saitama, Japan; 2Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan; 3Department of Developmental Anatomy and Regenerative Biology, National Defense Medical College, Tokorozawa, Saitama, Japan Background: Sebaceous adenomas are found mainly in elderly individuals and are usually tan, pink, or yellow nodules or papules, usually approximately 5 mm in the largest size. Case report: A 65-year-old man presented with a progressively enlarging exophytic lesion in the right eyelid for 3 months. External examination revealed a yellowish-pink growth measuring 18 × 13 × 14 mm. The lesion surface was covered by palpebral conjunctiva with fine papillary projections, vascularity, crusting, and ulceration. Two weeks later, the growth enlarged to 20 × 14 × 14 mm, and ulceration also expanded. An excisional biopsy with clear resection margins was performed. No malignancy was found in the stump. Histopathologically, the lesion was located principally within the cutaneous compartment and composed of multiple circumscribed sebaceous lobules, separated, and exhibiting no cytologic atypia. Cystic change was not evident, and no infiltrative growth pattern, pagetoid lesions, mitotic figures, and lymphovascular space invasion were observed. The Ki-67 nuclear antigen was detected in 10%–15% of cells located in the basal zone of the nodule. Fluorescence in situ hybridization showed low human epidermal growth factor receptor 2 amplification, suggesting no genetic changes. The clinical findings, lack of infiltrative border, low Ki-67 index, and low proliferative ability support a diagnosis of sebaceous adenoma. Conclusion: Sebaceous adenoma that shows excessively rapid growth due to hyperplasia may appear to be malignant. Histopathology, fluorescence in situ hybridization, and Ki-67 were useful to the diagnosis of the adenoma. Excisional biopsy with clear resection margins must be performed in rapidly growing tumors. Keywords: sebaceous adenoma, Ki-67, fluorescence in situ hybridization, sebaceous carcinoma |
| format |
article |
| author |
Takayama K Usui Y Ito M Goto H Takeuchi M |
| author_facet |
Takayama K Usui Y Ito M Goto H Takeuchi M |
| author_sort |
Takayama K |
| title |
A case of sebaceous adenoma of the eyelid showing excessively rapid growth |
| title_short |
A case of sebaceous adenoma of the eyelid showing excessively rapid growth |
| title_full |
A case of sebaceous adenoma of the eyelid showing excessively rapid growth |
| title_fullStr |
A case of sebaceous adenoma of the eyelid showing excessively rapid growth |
| title_full_unstemmed |
A case of sebaceous adenoma of the eyelid showing excessively rapid growth |
| title_sort |
case of sebaceous adenoma of the eyelid showing excessively rapid growth |
| publisher |
Dove Medical Press |
| publishDate |
2013 |
| url |
https://doaj.org/article/5f97aeda42c34d108732946a843ee574 |
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