Vestibular stimulation by 2G hypergravity modifies resynchronization in temperature rhythm in rats

Abstract Input from the light/dark (LD) cycle constitutes the primary synchronizing stimulus for the suprachiasmatic nucleus (SCN) circadian clock. However, the SCN can also be synchronized by non-photic inputs. Here, we hypothesized that the vestibular system, which detects head motion and orientat...

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Autores principales:	Tristan Martin, Tristan Bonargent, Stéphane Besnard, Gaëlle Quarck, Benoit Mauvieux, Eric Pigeon, Pierre Denise, Damien Davenne
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5f98ed2a89e24d77af91c7f7d03f7c1e
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spelling	oai:doaj.org-article:5f98ed2a89e24d77af91c7f7d03f7c1e2021-12-02T17:52:33ZVestibular stimulation by 2G hypergravity modifies resynchronization in temperature rhythm in rats10.1038/s41598-020-65496-x2045-2322https://doaj.org/article/5f98ed2a89e24d77af91c7f7d03f7c1e2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-65496-xhttps://doaj.org/toc/2045-2322Abstract Input from the light/dark (LD) cycle constitutes the primary synchronizing stimulus for the suprachiasmatic nucleus (SCN) circadian clock. However, the SCN can also be synchronized by non-photic inputs. Here, we hypothesized that the vestibular system, which detects head motion and orientation relative to gravity, may provide sensory inputs to synchronize circadian rhythmicity. We investigated the resynchronization of core temperature (Tc) circadian rhythm to a six-hour phase advance of the LD cycle (LD + 6) using hypergravity (2 G) as a vestibular stimulation in control and bilateral vestibular loss (BVL) rats. Three conditions were tested: an LD + 6 exposure alone, a series of seven 2 G pulses without LD + 6, and a series of seven one-hour 2 G pulses (once a day) following LD + 6. First, following LD + 6, sham rats exposed to 2 G pulses resynchronized earlier than BVL rats (p = 0.01), and earlier than sham rats exposed to LD + 6 alone (p = 0.002). Each 2 G pulse caused an acute drop of Tc in sham rats (−2.8 ± 0.3 °C; p < 0.001), while BVL rats remained unaffected. This confirms that the vestibular system influences chronobiological regulation and supports the hypothesis that vestibular input, like physical activity, should be considered as a potent time cue for biological rhythm synchronization, acting in synergy with the visual system.Tristan MartinTristan BonargentStéphane BesnardGaëlle QuarckBenoit MauvieuxEric PigeonPierre DeniseDamien DavenneNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tristan Martin Tristan Bonargent Stéphane Besnard Gaëlle Quarck Benoit Mauvieux Eric Pigeon Pierre Denise Damien Davenne Vestibular stimulation by 2G hypergravity modifies resynchronization in temperature rhythm in rats
description	Abstract Input from the light/dark (LD) cycle constitutes the primary synchronizing stimulus for the suprachiasmatic nucleus (SCN) circadian clock. However, the SCN can also be synchronized by non-photic inputs. Here, we hypothesized that the vestibular system, which detects head motion and orientation relative to gravity, may provide sensory inputs to synchronize circadian rhythmicity. We investigated the resynchronization of core temperature (Tc) circadian rhythm to a six-hour phase advance of the LD cycle (LD + 6) using hypergravity (2 G) as a vestibular stimulation in control and bilateral vestibular loss (BVL) rats. Three conditions were tested: an LD + 6 exposure alone, a series of seven 2 G pulses without LD + 6, and a series of seven one-hour 2 G pulses (once a day) following LD + 6. First, following LD + 6, sham rats exposed to 2 G pulses resynchronized earlier than BVL rats (p = 0.01), and earlier than sham rats exposed to LD + 6 alone (p = 0.002). Each 2 G pulse caused an acute drop of Tc in sham rats (−2.8 ± 0.3 °C; p < 0.001), while BVL rats remained unaffected. This confirms that the vestibular system influences chronobiological regulation and supports the hypothesis that vestibular input, like physical activity, should be considered as a potent time cue for biological rhythm synchronization, acting in synergy with the visual system.
format	article
author	Tristan Martin Tristan Bonargent Stéphane Besnard Gaëlle Quarck Benoit Mauvieux Eric Pigeon Pierre Denise Damien Davenne
author_facet	Tristan Martin Tristan Bonargent Stéphane Besnard Gaëlle Quarck Benoit Mauvieux Eric Pigeon Pierre Denise Damien Davenne
author_sort	Tristan Martin
title	Vestibular stimulation by 2G hypergravity modifies resynchronization in temperature rhythm in rats
title_short	Vestibular stimulation by 2G hypergravity modifies resynchronization in temperature rhythm in rats
title_full	Vestibular stimulation by 2G hypergravity modifies resynchronization in temperature rhythm in rats
title_fullStr	Vestibular stimulation by 2G hypergravity modifies resynchronization in temperature rhythm in rats
title_full_unstemmed	Vestibular stimulation by 2G hypergravity modifies resynchronization in temperature rhythm in rats
title_sort	vestibular stimulation by 2g hypergravity modifies resynchronization in temperature rhythm in rats
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5f98ed2a89e24d77af91c7f7d03f7c1e
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Vestibular stimulation by 2G hypergravity modifies resynchronization in temperature rhythm in rats

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