Effect of acute exercise on prostate cancer cell growth.

Physical activity is associated with reduced risk of several cancers, including aggressive prostate cancer. The mechanisms mediating the effects are not yet understood; among the candidates are modifications of endogenous hormone levels. Long-term exercise is known to reduce serum levels of growth s...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Helene Rundqvist, Martin Augsten, Anna Strömberg, Eric Rullman, Sara Mijwel, Pedram Kharaziha, Theocharis Panaretakis, Thomas Gustafsson, Arne Östman
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5f99e53bf0f74cce8ad8bcec16662c46
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5f99e53bf0f74cce8ad8bcec16662c46
record_format	dspace
spelling	oai:doaj.org-article:5f99e53bf0f74cce8ad8bcec16662c462021-11-18T07:38:27ZEffect of acute exercise on prostate cancer cell growth.1932-620310.1371/journal.pone.0067579https://doaj.org/article/5f99e53bf0f74cce8ad8bcec16662c462013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23861774/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Physical activity is associated with reduced risk of several cancers, including aggressive prostate cancer. The mechanisms mediating the effects are not yet understood; among the candidates are modifications of endogenous hormone levels. Long-term exercise is known to reduce serum levels of growth stimulating hormones. In contrast, the endocrine effects of acute endurance exercise include increased levels of mitogenic factors such as GH and IGF-1. It can be speculated that the elevation of serum growth factors may be detrimental to prostate cancer progression into malignancy. The incentive of the current study is to evaluate the effect of acute exercise serum on prostate cancer cell growth. We designed an exercise intervention where 10 male individuals performed 60 minutes of bicycle exercise at increasing intensity. Serum samples were obtained before (rest serum) and after completed exercise (exercise serum). The established prostate cancer cell line LNCaP was exposed to exercise or rest serum. Exercise serum from 9 out of 10 individuals had a growth inhibitory effect on LNCaP cells. Incubation with pooled exercise serum resulted in a 31% inhibition of LNCaP growth and pre-incubation before subcutaneous injection into SCID mice caused a delay in tumor formation. Serum analyses indicated two possible candidates for the effect; increased levels of IGFBP-1 and reduced levels of EGF. In conclusion, despite the fear of possible detrimental effects of acute exercise serum on tumor cell growth, we show that even the short-term effects seem to add to the overall beneficial influence of exercise on neoplasia.Helene RundqvistMartin AugstenAnna StrömbergEric RullmanSara MijwelPedram KharazihaTheocharis PanaretakisThomas GustafssonArne ÖstmanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 7, p e67579 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Helene Rundqvist Martin Augsten Anna Strömberg Eric Rullman Sara Mijwel Pedram Kharaziha Theocharis Panaretakis Thomas Gustafsson Arne Östman Effect of acute exercise on prostate cancer cell growth.
description	Physical activity is associated with reduced risk of several cancers, including aggressive prostate cancer. The mechanisms mediating the effects are not yet understood; among the candidates are modifications of endogenous hormone levels. Long-term exercise is known to reduce serum levels of growth stimulating hormones. In contrast, the endocrine effects of acute endurance exercise include increased levels of mitogenic factors such as GH and IGF-1. It can be speculated that the elevation of serum growth factors may be detrimental to prostate cancer progression into malignancy. The incentive of the current study is to evaluate the effect of acute exercise serum on prostate cancer cell growth. We designed an exercise intervention where 10 male individuals performed 60 minutes of bicycle exercise at increasing intensity. Serum samples were obtained before (rest serum) and after completed exercise (exercise serum). The established prostate cancer cell line LNCaP was exposed to exercise or rest serum. Exercise serum from 9 out of 10 individuals had a growth inhibitory effect on LNCaP cells. Incubation with pooled exercise serum resulted in a 31% inhibition of LNCaP growth and pre-incubation before subcutaneous injection into SCID mice caused a delay in tumor formation. Serum analyses indicated two possible candidates for the effect; increased levels of IGFBP-1 and reduced levels of EGF. In conclusion, despite the fear of possible detrimental effects of acute exercise serum on tumor cell growth, we show that even the short-term effects seem to add to the overall beneficial influence of exercise on neoplasia.
format	article
author	Helene Rundqvist Martin Augsten Anna Strömberg Eric Rullman Sara Mijwel Pedram Kharaziha Theocharis Panaretakis Thomas Gustafsson Arne Östman
author_facet	Helene Rundqvist Martin Augsten Anna Strömberg Eric Rullman Sara Mijwel Pedram Kharaziha Theocharis Panaretakis Thomas Gustafsson Arne Östman
author_sort	Helene Rundqvist
title	Effect of acute exercise on prostate cancer cell growth.
title_short	Effect of acute exercise on prostate cancer cell growth.
title_full	Effect of acute exercise on prostate cancer cell growth.
title_fullStr	Effect of acute exercise on prostate cancer cell growth.
title_full_unstemmed	Effect of acute exercise on prostate cancer cell growth.
title_sort	effect of acute exercise on prostate cancer cell growth.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/5f99e53bf0f74cce8ad8bcec16662c46
work_keys_str_mv	AT helenerundqvist effectofacuteexerciseonprostatecancercellgrowth AT martinaugsten effectofacuteexerciseonprostatecancercellgrowth AT annastromberg effectofacuteexerciseonprostatecancercellgrowth AT ericrullman effectofacuteexerciseonprostatecancercellgrowth AT saramijwel effectofacuteexerciseonprostatecancercellgrowth AT pedramkharaziha effectofacuteexerciseonprostatecancercellgrowth AT theocharispanaretakis effectofacuteexerciseonprostatecancercellgrowth AT thomasgustafsson effectofacuteexerciseonprostatecancercellgrowth AT arneostman effectofacuteexerciseonprostatecancercellgrowth
_version_	1718423162973061120

Effect of acute exercise on prostate cancer cell growth.

Ejemplares similares