The role of ceRNA-mediated diagnosis and therapy in hepatocellular carcinoma

Abstract Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide due to its high degree of malignancy, high incidence, and low survival rate. However, the underlying mechanisms of hepatocarcinogenesis remain unclear. Long non coding RNA (lncRNA) has been shown a...

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Autores principales:	Yi Shi, Ji-Bin Liu, Jing Deng, Da-Zhi Zou, Jian-Jun Wu, Ya-Hong Cao, Jie Yin, Yu-Shui Ma, Fu Da, Wen Li
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Epidemiology HCC ceRNA ceRNET Mechanism Function Genetics QH426-470
Acceso en línea:	https://doaj.org/article/5f9ac49ea2604ea49578bba60363cc81
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spelling	oai:doaj.org-article:5f9ac49ea2604ea49578bba60363cc812021-11-14T12:10:57ZThe role of ceRNA-mediated diagnosis and therapy in hepatocellular carcinoma10.1186/s41065-021-00208-71601-5223https://doaj.org/article/5f9ac49ea2604ea49578bba60363cc812021-11-01T00:00:00Zhttps://doi.org/10.1186/s41065-021-00208-7https://doaj.org/toc/1601-5223Abstract Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide due to its high degree of malignancy, high incidence, and low survival rate. However, the underlying mechanisms of hepatocarcinogenesis remain unclear. Long non coding RNA (lncRNA) has been shown as a novel type of RNA. lncRNA by acting as ceRNA can participate in various biological processes of HCC cells, such as tumor cell proliferation, migration, invasion, apoptosis and drug resistance by regulating downstream target gene expression and cancer-related signaling pathways. Meanwhile, lncRNA can predict the efficacy of treatment strategies for HCC and serve as a potential target for the diagnosis and treatment of HCC. Therefore, lncRNA serving as ceRNA may become a vital candidate biomarker for clinical diagnosis and treatment. In this review, the epidemiology of HCC, including morbidity, mortality, regional distribution, risk factors, and current treatment advances, was briefly discussed, and some biological functions of lncRNA in HCC were summarized with emphasis on the molecular mechanism and clinical application of lncRNA-mediated ceRNA regulatory network in HCC. This paper can contribute to the better understanding of the mechanism of the influence of lncRNA-mediated ceRNA networks (ceRNETs) on HCC and provide directions and strategies for future studies.Yi ShiJi-Bin LiuJing DengDa-Zhi ZouJian-Jun WuYa-Hong CaoJie YinYu-Shui MaFu DaWen LiBMCarticleEpidemiologyHCCceRNAceRNETMechanismFunctionGeneticsQH426-470ENHereditas, Vol 158, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Epidemiology HCC ceRNA ceRNET Mechanism Function Genetics QH426-470
spellingShingle	Epidemiology HCC ceRNA ceRNET Mechanism Function Genetics QH426-470 Yi Shi Ji-Bin Liu Jing Deng Da-Zhi Zou Jian-Jun Wu Ya-Hong Cao Jie Yin Yu-Shui Ma Fu Da Wen Li The role of ceRNA-mediated diagnosis and therapy in hepatocellular carcinoma
description	Abstract Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide due to its high degree of malignancy, high incidence, and low survival rate. However, the underlying mechanisms of hepatocarcinogenesis remain unclear. Long non coding RNA (lncRNA) has been shown as a novel type of RNA. lncRNA by acting as ceRNA can participate in various biological processes of HCC cells, such as tumor cell proliferation, migration, invasion, apoptosis and drug resistance by regulating downstream target gene expression and cancer-related signaling pathways. Meanwhile, lncRNA can predict the efficacy of treatment strategies for HCC and serve as a potential target for the diagnosis and treatment of HCC. Therefore, lncRNA serving as ceRNA may become a vital candidate biomarker for clinical diagnosis and treatment. In this review, the epidemiology of HCC, including morbidity, mortality, regional distribution, risk factors, and current treatment advances, was briefly discussed, and some biological functions of lncRNA in HCC were summarized with emphasis on the molecular mechanism and clinical application of lncRNA-mediated ceRNA regulatory network in HCC. This paper can contribute to the better understanding of the mechanism of the influence of lncRNA-mediated ceRNA networks (ceRNETs) on HCC and provide directions and strategies for future studies.
format	article
author	Yi Shi Ji-Bin Liu Jing Deng Da-Zhi Zou Jian-Jun Wu Ya-Hong Cao Jie Yin Yu-Shui Ma Fu Da Wen Li
author_facet	Yi Shi Ji-Bin Liu Jing Deng Da-Zhi Zou Jian-Jun Wu Ya-Hong Cao Jie Yin Yu-Shui Ma Fu Da Wen Li
author_sort	Yi Shi
title	The role of ceRNA-mediated diagnosis and therapy in hepatocellular carcinoma
title_short	The role of ceRNA-mediated diagnosis and therapy in hepatocellular carcinoma
title_full	The role of ceRNA-mediated diagnosis and therapy in hepatocellular carcinoma
title_fullStr	The role of ceRNA-mediated diagnosis and therapy in hepatocellular carcinoma
title_full_unstemmed	The role of ceRNA-mediated diagnosis and therapy in hepatocellular carcinoma
title_sort	role of cerna-mediated diagnosis and therapy in hepatocellular carcinoma
publisher	BMC
publishDate	2021
url	https://doaj.org/article/5f9ac49ea2604ea49578bba60363cc81
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The role of ceRNA-mediated diagnosis and therapy in hepatocellular carcinoma

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