Genetic polymorphisms in Sox17 associated with intracranial aneurysm in Chinese Han people: a genotype-phenotype study

Mengqi Li,1,2,* Weihan Wang,1,2,* Lin Zhang,3,* Wenqiang Xin,1,2,* Yan Zhao,1,2 Linchun Huan,4 Jianjun Yu,4 Hao Zhang,1,2 Jianning Zhang,1,2 Shuyuan Yang,1,2 Degang Liang,5,* Weidong Yang,1,2,* Xinyu Yang1,2,* 1Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, People...

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Autores principales:	Li M, Wang W, Zhang L, Xin W, Zhao Y, Huan L, Yu J, Zhang H, Zhang J, Yang S, Liang D, Yang W, Yang X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Intracranial aneurysm Sox17 genetics cerebral vascular disease Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/5f9b206edaf34197aca51179b54ecc4b
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spelling	oai:doaj.org-article:5f9b206edaf34197aca51179b54ecc4b2021-12-02T05:19:07ZGenetic polymorphisms in Sox17 associated with intracranial aneurysm in Chinese Han people: a genotype-phenotype study1178-2021https://doaj.org/article/5f9b206edaf34197aca51179b54ecc4b2019-04-01T00:00:00Zhttps://www.dovepress.com/genetic-polymorphisms-in-sox17-associated-with-intracranial-aneurysm-i-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Mengqi Li,1,2,* Weihan Wang,1,2,* Lin Zhang,3,* Wenqiang Xin,1,2,* Yan Zhao,1,2 Linchun Huan,4 Jianjun Yu,4 Hao Zhang,1,2 Jianning Zhang,1,2 Shuyuan Yang,1,2 Degang Liang,5,* Weidong Yang,1,2,* Xinyu Yang1,2,* 1Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China; 2Key Laboratory of Post-Neurotrauma Neurorepair and Regeneration in Central Nervous System, Ministry of Education in China and Tianjin, Tianjin Neurological Institute, Tianjin, People’s Republic of China; 3Department of Neurosurgery, Linyi People’s Hospital, Shandong, People’s Republic of China; 4Department of Cardio-Thoracic Surgery, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China; 5Department of Neurosurgery, Tianjin Fifth Central Hospital, Tianjin, People’s Republic of China *These authors contributed equally to this work Purpose: Genetic factors play a vital role in intracranial aneurysm (IA) onset and development. Studying the relationship between IA and the Sox17 polymorphisms in diverse populations is essential for establishing credibility.Patients and methods: We collected blood samples derived from a total of 596 sporadic IA patients and 600 individual controls in several medical institutes in China. We used the Sequenom MassArray system for single nucleotide polymorphisms (SNPs) genotyping after DNA extraction. The SNPs data was tested and analyzed in PLINK (version 1.9). Multiple-testing was performed in PLINK to make the statistics more rigorous and accurate.Results: We found that the allelic G of rs1072737 (OR=1.303, genomic-control corrected P-value =0.001032) is a risk allele, while the allelic G of rs9298506 (OR=0.7253, genomic-control corrected P-value =0.01559) is a protective allele in Chinese Han people.Conclusion: The allelic G of rs1072737 is a risk factor for IA, while the allelic G of rs9298506 serves as a protective factor for IA in Chinese Han people. Keywords: intracranial aneurysm, Sox17, genetics, cerebral vascular disease  Li MWang WZhang LXin WZhao YHuan LYu JZhang HZhang JYang SLiang DYang WYang XDove Medical PressarticleIntracranial aneurysmSox17geneticscerebral vascular diseaseNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 779-783 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Intracranial aneurysm Sox17 genetics cerebral vascular disease Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Intracranial aneurysm Sox17 genetics cerebral vascular disease Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Li M Wang W Zhang L Xin W Zhao Y Huan L Yu J Zhang H Zhang J Yang S Liang D Yang W Yang X Genetic polymorphisms in Sox17 associated with intracranial aneurysm in Chinese Han people: a genotype-phenotype study
description	Mengqi Li,1,2,* Weihan Wang,1,2,* Lin Zhang,3,* Wenqiang Xin,1,2,* Yan Zhao,1,2 Linchun Huan,4 Jianjun Yu,4 Hao Zhang,1,2 Jianning Zhang,1,2 Shuyuan Yang,1,2 Degang Liang,5,* Weidong Yang,1,2,* Xinyu Yang1,2,* 1Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China; 2Key Laboratory of Post-Neurotrauma Neurorepair and Regeneration in Central Nervous System, Ministry of Education in China and Tianjin, Tianjin Neurological Institute, Tianjin, People’s Republic of China; 3Department of Neurosurgery, Linyi People’s Hospital, Shandong, People’s Republic of China; 4Department of Cardio-Thoracic Surgery, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China; 5Department of Neurosurgery, Tianjin Fifth Central Hospital, Tianjin, People’s Republic of China *These authors contributed equally to this work Purpose: Genetic factors play a vital role in intracranial aneurysm (IA) onset and development. Studying the relationship between IA and the Sox17 polymorphisms in diverse populations is essential for establishing credibility.Patients and methods: We collected blood samples derived from a total of 596 sporadic IA patients and 600 individual controls in several medical institutes in China. We used the Sequenom MassArray system for single nucleotide polymorphisms (SNPs) genotyping after DNA extraction. The SNPs data was tested and analyzed in PLINK (version 1.9). Multiple-testing was performed in PLINK to make the statistics more rigorous and accurate.Results: We found that the allelic G of rs1072737 (OR=1.303, genomic-control corrected P-value =0.001032) is a risk allele, while the allelic G of rs9298506 (OR=0.7253, genomic-control corrected P-value =0.01559) is a protective allele in Chinese Han people.Conclusion: The allelic G of rs1072737 is a risk factor for IA, while the allelic G of rs9298506 serves as a protective factor for IA in Chinese Han people. Keywords: intracranial aneurysm, Sox17, genetics, cerebral vascular disease
format	article
author	Li M Wang W Zhang L Xin W Zhao Y Huan L Yu J Zhang H Zhang J Yang S Liang D Yang W Yang X
author_facet	Li M Wang W Zhang L Xin W Zhao Y Huan L Yu J Zhang H Zhang J Yang S Liang D Yang W Yang X
author_sort	Li M
title	Genetic polymorphisms in Sox17 associated with intracranial aneurysm in Chinese Han people: a genotype-phenotype study
title_short	Genetic polymorphisms in Sox17 associated with intracranial aneurysm in Chinese Han people: a genotype-phenotype study
title_full	Genetic polymorphisms in Sox17 associated with intracranial aneurysm in Chinese Han people: a genotype-phenotype study
title_fullStr	Genetic polymorphisms in Sox17 associated with intracranial aneurysm in Chinese Han people: a genotype-phenotype study
title_full_unstemmed	Genetic polymorphisms in Sox17 associated with intracranial aneurysm in Chinese Han people: a genotype-phenotype study
title_sort	genetic polymorphisms in sox17 associated with intracranial aneurysm in chinese han people: a genotype-phenotype study
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/5f9b206edaf34197aca51179b54ecc4b
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Genetic polymorphisms in Sox17 associated with intracranial aneurysm in Chinese Han people: a genotype-phenotype study

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