The Clinical and Epidemiological Study of Children with Hand, Foot, and Mouth Disease in Hunan, China from 2013 to 2017

Abstract Hand, foot, and mouth disease (HFMD) is endemic in the Pacific region, especially in mainland China. The case-fatality ratio of HFMD is increasing steadily. Knowledge of the changing epidemiology of HFMD in different regions is necessary for implementing appropriate intervention strategies....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jun Qiu, Haipeng Yan, Nianci Cheng, Xiulan Lu, Xia Hu, Lijuan Liang, Zhenghui Xiao, Lihong Tan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5f9b5dbfa9554e3ca5380d2f25187eef
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5f9b5dbfa9554e3ca5380d2f25187eef
record_format	dspace
spelling	oai:doaj.org-article:5f9b5dbfa9554e3ca5380d2f25187eef2021-12-02T16:07:53ZThe Clinical and Epidemiological Study of Children with Hand, Foot, and Mouth Disease in Hunan, China from 2013 to 201710.1038/s41598-019-48259-12045-2322https://doaj.org/article/5f9b5dbfa9554e3ca5380d2f25187eef2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-48259-1https://doaj.org/toc/2045-2322Abstract Hand, foot, and mouth disease (HFMD) is endemic in the Pacific region, especially in mainland China. The case-fatality ratio of HFMD is increasing steadily. Knowledge of the changing epidemiology of HFMD in different regions is necessary for implementing appropriate intervention strategies. In this study, we describe the clinical and epidemiological characteristics of HFMD in Hunan Children’s Hospital between 2013 and 2017. A total of 7203 patients with HFMD were admitted, with complication and mortality rates of 35.62% and 0.78%, respectively. The total number of children with HFMD, proportion of severely ill children, and HFMD mortality rate were the highest in 2014. The number of cases caused by EV-A71 and CV-A16 decreased continuously, while the number of cases caused by ‘other enteroviruses’ increased yearly since 2014, suggesting that other enteric viruses will gradually replace EV-A71 and CV-A16 as the main pathogenic HFMD agents. Furthermore, EV-A71 and mixed infections accounted for the high case fatality rates in children with severe HFMD, among whom EV-A71 infection resulted in the highest complication and mortality rates; the mild form of the disease was dominated by ‘other enteroviruses’. In conclusion, the changing etiological pattern highlights the need to improve pathogen surveillance and vaccine strategies for HFMD control.Jun QiuHaipeng YanNianci ChengXiulan LuXia HuLijuan LiangZhenghui XiaoLihong TanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-7 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jun Qiu Haipeng Yan Nianci Cheng Xiulan Lu Xia Hu Lijuan Liang Zhenghui Xiao Lihong Tan The Clinical and Epidemiological Study of Children with Hand, Foot, and Mouth Disease in Hunan, China from 2013 to 2017
description	Abstract Hand, foot, and mouth disease (HFMD) is endemic in the Pacific region, especially in mainland China. The case-fatality ratio of HFMD is increasing steadily. Knowledge of the changing epidemiology of HFMD in different regions is necessary for implementing appropriate intervention strategies. In this study, we describe the clinical and epidemiological characteristics of HFMD in Hunan Children’s Hospital between 2013 and 2017. A total of 7203 patients with HFMD were admitted, with complication and mortality rates of 35.62% and 0.78%, respectively. The total number of children with HFMD, proportion of severely ill children, and HFMD mortality rate were the highest in 2014. The number of cases caused by EV-A71 and CV-A16 decreased continuously, while the number of cases caused by ‘other enteroviruses’ increased yearly since 2014, suggesting that other enteric viruses will gradually replace EV-A71 and CV-A16 as the main pathogenic HFMD agents. Furthermore, EV-A71 and mixed infections accounted for the high case fatality rates in children with severe HFMD, among whom EV-A71 infection resulted in the highest complication and mortality rates; the mild form of the disease was dominated by ‘other enteroviruses’. In conclusion, the changing etiological pattern highlights the need to improve pathogen surveillance and vaccine strategies for HFMD control.
format	article
author	Jun Qiu Haipeng Yan Nianci Cheng Xiulan Lu Xia Hu Lijuan Liang Zhenghui Xiao Lihong Tan
author_facet	Jun Qiu Haipeng Yan Nianci Cheng Xiulan Lu Xia Hu Lijuan Liang Zhenghui Xiao Lihong Tan
author_sort	Jun Qiu
title	The Clinical and Epidemiological Study of Children with Hand, Foot, and Mouth Disease in Hunan, China from 2013 to 2017
title_short	The Clinical and Epidemiological Study of Children with Hand, Foot, and Mouth Disease in Hunan, China from 2013 to 2017
title_full	The Clinical and Epidemiological Study of Children with Hand, Foot, and Mouth Disease in Hunan, China from 2013 to 2017
title_fullStr	The Clinical and Epidemiological Study of Children with Hand, Foot, and Mouth Disease in Hunan, China from 2013 to 2017
title_full_unstemmed	The Clinical and Epidemiological Study of Children with Hand, Foot, and Mouth Disease in Hunan, China from 2013 to 2017
title_sort	clinical and epidemiological study of children with hand, foot, and mouth disease in hunan, china from 2013 to 2017
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/5f9b5dbfa9554e3ca5380d2f25187eef
work_keys_str_mv	AT junqiu theclinicalandepidemiologicalstudyofchildrenwithhandfootandmouthdiseaseinhunanchinafrom2013to2017 AT haipengyan theclinicalandepidemiologicalstudyofchildrenwithhandfootandmouthdiseaseinhunanchinafrom2013to2017 AT niancicheng theclinicalandepidemiologicalstudyofchildrenwithhandfootandmouthdiseaseinhunanchinafrom2013to2017 AT xiulanlu theclinicalandepidemiologicalstudyofchildrenwithhandfootandmouthdiseaseinhunanchinafrom2013to2017 AT xiahu theclinicalandepidemiologicalstudyofchildrenwithhandfootandmouthdiseaseinhunanchinafrom2013to2017 AT lijuanliang theclinicalandepidemiologicalstudyofchildrenwithhandfootandmouthdiseaseinhunanchinafrom2013to2017 AT zhenghuixiao theclinicalandepidemiologicalstudyofchildrenwithhandfootandmouthdiseaseinhunanchinafrom2013to2017 AT lihongtan theclinicalandepidemiologicalstudyofchildrenwithhandfootandmouthdiseaseinhunanchinafrom2013to2017 AT junqiu clinicalandepidemiologicalstudyofchildrenwithhandfootandmouthdiseaseinhunanchinafrom2013to2017 AT haipengyan clinicalandepidemiologicalstudyofchildrenwithhandfootandmouthdiseaseinhunanchinafrom2013to2017 AT niancicheng clinicalandepidemiologicalstudyofchildrenwithhandfootandmouthdiseaseinhunanchinafrom2013to2017 AT xiulanlu clinicalandepidemiologicalstudyofchildrenwithhandfootandmouthdiseaseinhunanchinafrom2013to2017 AT xiahu clinicalandepidemiologicalstudyofchildrenwithhandfootandmouthdiseaseinhunanchinafrom2013to2017 AT lijuanliang clinicalandepidemiologicalstudyofchildrenwithhandfootandmouthdiseaseinhunanchinafrom2013to2017 AT zhenghuixiao clinicalandepidemiologicalstudyofchildrenwithhandfootandmouthdiseaseinhunanchinafrom2013to2017 AT lihongtan clinicalandepidemiologicalstudyofchildrenwithhandfootandmouthdiseaseinhunanchinafrom2013to2017
_version_	1718384658185453568

The Clinical and Epidemiological Study of Children with Hand, Foot, and Mouth Disease in Hunan, China from 2013 to 2017

Ejemplares similares