Dynamics in IgM and IgG antibodies against a polysaccharide capsule-containing complex of various <i>S. pneumonia</i> and <i>H. influenza</i> type b serotypes in children with chronic lung and bronchial inflammatory diseases after vaccination with “Pneumo-23” and “Act-HIB”

A lead place among pathogens resulting in pediatric chronic bronchopulmonary diseases is held by S. pneumoniae and Haemophilus influenzae. Vaccination against pneumococcal and hemophilic infections is approved and recommended for patients with chronic pathologies, but no clear recommendations for co...

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Autores principales:	E. S. Korovkina, A. V. Krakovskaya, M. P. Kostinov, V. K. Kozlov, N. E. Jastrebova, O. O. Magarshak, V. B. Polishchuk
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2020
Materias:	igg igm streptococcus pneumoniae haemophilus influenzae type b vaccination children chronic inflammatory lung diseases bronchial asthma adaptive immunity Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/5f9c0d7d927d4d21a63281fb87843959
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spelling	oai:doaj.org-article:5f9c0d7d927d4d21a63281fb878439592021-11-22T07:09:53ZDynamics in IgM and IgG antibodies against a polysaccharide capsule-containing complex of various <i>S. pneumonia</i> and <i>H. influenza</i> type b serotypes in children with chronic lung and bronchial inflammatory diseases after vaccination with “Pneumo-23” and “Act-HIB”2220-76192313-739810.15789/2220-7619-2019-5-6-713-722https://doaj.org/article/5f9c0d7d927d4d21a63281fb878439592020-02-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/640https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398A lead place among pathogens resulting in pediatric chronic bronchopulmonary diseases is held by S. pneumoniae and Haemophilus influenzae. Vaccination against pneumococcal and hemophilic infections is approved and recommended for patients with chronic pathologies, but no clear recommendations for combined use of Pneumo-23 and Act-HIB vaccines in children with congenital pulmonary malformations and bronchial asthma were proposed.Materials and methods. There were enrolled 92 children aged 0–17 years old with chronic bronchopulmonary diseases; 55 healthy children, and 57 unvaccinated children with chronic broncho-pulmonary pathology were included into control group. Mono- and combination vaccination by Pneumo-23 and/or Act-HIB was performed in remission period. IgM and IgG level against H. influenzae antigens, H. influenzae type b, to S. pneumoniae (serotypes 3, 6B, 9N, 23F) vaccine-specific polysaccharide as well as polysaccharide complex antigens were measured by using ELISA developed by us. Statistical processing was carried out by methods of descriptive, parametric and nonparametric statistics by using Statistica 5.0 software.Results. Vaccination with Pneumo 23 was accompanied by IgG production against serotypes 3, 6, 9N, 23F-derived polysaccharide. A markedly increased anti-serotype 3 and 23F antibody level was observed 6 months after vaccination. Moreover, a significant increase in anti-polysaccharide 23F and anti-vaccine-derived polysaccharide IgM levels was found 1 month after the onset. In addition, anti-serotype 6B and 9N IgM antibodies were maintained 18 months after vaccination at high level, whereas it was significantly elevated against serotypes 3, 23F. Assessing an effectiveness of vaccine prophylaxis against Hemophilus type b infection, it was shown that a significantly increased anti-vaccine-derived polysaccharide IgM level was found 1, 6, 18 months after Act-HIB vaccination. In addition, IgG to the anti-H. influenzae type b polysaccharide tended to rise 1 month after the vaccination.Summary. Children with chronic bronchopulmonary diseases vaccinated by Pneumo-23 and Act-HIB demonstrated activated adaptive immunity manifested by increased vaccine-derived antigen-specific IgM and IgG antibodies.E. S. KorovkinaA. V. KrakovskayaM. P. KostinovV. K. KozlovN. E. JastrebovaO. O. MagarshakV. B. PolishchukSankt-Peterburg : NIIÈM imeni Pasteraarticleiggigmstreptococcus pneumoniaehaemophilus influenzae type bvaccinationchildrenchronic inflammatory lung diseasesbronchial asthmaadaptive immunityInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 9, Iss 5-6, Pp 713-722 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	igg igm streptococcus pneumoniae haemophilus influenzae type b vaccination children chronic inflammatory lung diseases bronchial asthma adaptive immunity Infectious and parasitic diseases RC109-216
spellingShingle	igg igm streptococcus pneumoniae haemophilus influenzae type b vaccination children chronic inflammatory lung diseases bronchial asthma adaptive immunity Infectious and parasitic diseases RC109-216 E. S. Korovkina A. V. Krakovskaya M. P. Kostinov V. K. Kozlov N. E. Jastrebova O. O. Magarshak V. B. Polishchuk Dynamics in IgM and IgG antibodies against a polysaccharide capsule-containing complex of various <i>S. pneumonia</i> and <i>H. influenza</i> type b serotypes in children with chronic lung and bronchial inflammatory diseases after vaccination with “Pneumo-23” and “Act-HIB”
description	A lead place among pathogens resulting in pediatric chronic bronchopulmonary diseases is held by S. pneumoniae and Haemophilus influenzae. Vaccination against pneumococcal and hemophilic infections is approved and recommended for patients with chronic pathologies, but no clear recommendations for combined use of Pneumo-23 and Act-HIB vaccines in children with congenital pulmonary malformations and bronchial asthma were proposed.Materials and methods. There were enrolled 92 children aged 0–17 years old with chronic bronchopulmonary diseases; 55 healthy children, and 57 unvaccinated children with chronic broncho-pulmonary pathology were included into control group. Mono- and combination vaccination by Pneumo-23 and/or Act-HIB was performed in remission period. IgM and IgG level against H. influenzae antigens, H. influenzae type b, to S. pneumoniae (serotypes 3, 6B, 9N, 23F) vaccine-specific polysaccharide as well as polysaccharide complex antigens were measured by using ELISA developed by us. Statistical processing was carried out by methods of descriptive, parametric and nonparametric statistics by using Statistica 5.0 software.Results. Vaccination with Pneumo 23 was accompanied by IgG production against serotypes 3, 6, 9N, 23F-derived polysaccharide. A markedly increased anti-serotype 3 and 23F antibody level was observed 6 months after vaccination. Moreover, a significant increase in anti-polysaccharide 23F and anti-vaccine-derived polysaccharide IgM levels was found 1 month after the onset. In addition, anti-serotype 6B and 9N IgM antibodies were maintained 18 months after vaccination at high level, whereas it was significantly elevated against serotypes 3, 23F. Assessing an effectiveness of vaccine prophylaxis against Hemophilus type b infection, it was shown that a significantly increased anti-vaccine-derived polysaccharide IgM level was found 1, 6, 18 months after Act-HIB vaccination. In addition, IgG to the anti-H. influenzae type b polysaccharide tended to rise 1 month after the vaccination.Summary. Children with chronic bronchopulmonary diseases vaccinated by Pneumo-23 and Act-HIB demonstrated activated adaptive immunity manifested by increased vaccine-derived antigen-specific IgM and IgG antibodies.
format	article
author	E. S. Korovkina A. V. Krakovskaya M. P. Kostinov V. K. Kozlov N. E. Jastrebova O. O. Magarshak V. B. Polishchuk
author_facet	E. S. Korovkina A. V. Krakovskaya M. P. Kostinov V. K. Kozlov N. E. Jastrebova O. O. Magarshak V. B. Polishchuk
author_sort	E. S. Korovkina
title	Dynamics in IgM and IgG antibodies against a polysaccharide capsule-containing complex of various <i>S. pneumonia</i> and <i>H. influenza</i> type b serotypes in children with chronic lung and bronchial inflammatory diseases after vaccination with “Pneumo-23” and “Act-HIB”
title_short	Dynamics in IgM and IgG antibodies against a polysaccharide capsule-containing complex of various <i>S. pneumonia</i> and <i>H. influenza</i> type b serotypes in children with chronic lung and bronchial inflammatory diseases after vaccination with “Pneumo-23” and “Act-HIB”
title_full	Dynamics in IgM and IgG antibodies against a polysaccharide capsule-containing complex of various <i>S. pneumonia</i> and <i>H. influenza</i> type b serotypes in children with chronic lung and bronchial inflammatory diseases after vaccination with “Pneumo-23” and “Act-HIB”
title_fullStr	Dynamics in IgM and IgG antibodies against a polysaccharide capsule-containing complex of various <i>S. pneumonia</i> and <i>H. influenza</i> type b serotypes in children with chronic lung and bronchial inflammatory diseases after vaccination with “Pneumo-23” and “Act-HIB”
title_full_unstemmed	Dynamics in IgM and IgG antibodies against a polysaccharide capsule-containing complex of various <i>S. pneumonia</i> and <i>H. influenza</i> type b serotypes in children with chronic lung and bronchial inflammatory diseases after vaccination with “Pneumo-23” and “Act-HIB”
title_sort	dynamics in igm and igg antibodies against a polysaccharide capsule-containing complex of various <i>s. pneumonia</i> and <i>h. influenza</i> type b serotypes in children with chronic lung and bronchial inflammatory diseases after vaccination with “pneumo-23” and “act-hib”
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2020
url	https://doaj.org/article/5f9c0d7d927d4d21a63281fb87843959
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Dynamics in IgM and IgG antibodies against a polysaccharide capsule-containing complex of various <i>S. pneumonia</i> and <i>H. influenza</i> type b serotypes in children with chronic lung and bronchial inflammatory diseases after vaccination with “Pneumo-23” and “Act-HIB”

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