Cytokine and Chemokine Profiling in Patients with Hand, Foot and Mouth Disease in Singapore and Malaysia

Abstract Hand, foot and mouth disease (HFMD) is a prevalent contagious childhood disease typically associated with fever, oral lesions and limb exanthema. While HFMD is caused by a plethora of serotypes of viruses under the genus Enterovirus within the Picornaviridae family, Coxsackievirus A16 (CV-A...

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Autores principales:	Fiona Mei Shan Teo, Min Nyo, Anng Anng Wong, Natalie Woon Hui Tan, Mia Tuang Koh, Yoke Fun Chan, Chia Yin Chong, Justin Jang Hann Chu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5f9c3f12b30e48d685bfe030beea734d
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spelling	oai:doaj.org-article:5f9c3f12b30e48d685bfe030beea734d2021-12-02T15:07:49ZCytokine and Chemokine Profiling in Patients with Hand, Foot and Mouth Disease in Singapore and Malaysia10.1038/s41598-018-22379-62045-2322https://doaj.org/article/5f9c3f12b30e48d685bfe030beea734d2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-22379-6https://doaj.org/toc/2045-2322Abstract Hand, foot and mouth disease (HFMD) is a prevalent contagious childhood disease typically associated with fever, oral lesions and limb exanthema. While HFMD is caused by a plethora of serotypes of viruses under the genus Enterovirus within the Picornaviridae family, Coxsackievirus A16 (CV-A16) and Enterovirus 71 (EV-A71) are considered the main etiological agents. In recent years however, other viruses have also been isolated in considerable numbers from infected individuals in many regions, joining the legion commonly associated with HFMD. The present study investigated the cytokine and chemokine profiles of HFMD patients from Singapore and Malaysia for the first time. Comparative cohort studies of EV-A71-associated HFMD cases revealed that the Malaysia cohort had a distinct profile from the Singapore cohort, and this could be partly attributed by different EV-A71 genotypes. As the isolation of CV-A6, instead of CV-A16, had become prevalent in the Singapore cohort, it was also of particular interest to study the differential cytokine and chemokine profiles. Our data revealed that overlapping as well as unique profiles exist between the two major causative clinical isolates in the Singapore cohort. Having a better understanding of the respective immunological profiles could be useful for more accurate HFMD diagnosis, which is imperative for disease transmission control until multi-valent vaccines and/or broad-spectrum anti-viral drugs become available.Fiona Mei Shan TeoMin NyoAnng Anng WongNatalie Woon Hui TanMia Tuang KohYoke Fun ChanChia Yin ChongJustin Jang Hann ChuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fiona Mei Shan Teo Min Nyo Anng Anng Wong Natalie Woon Hui Tan Mia Tuang Koh Yoke Fun Chan Chia Yin Chong Justin Jang Hann Chu Cytokine and Chemokine Profiling in Patients with Hand, Foot and Mouth Disease in Singapore and Malaysia
description	Abstract Hand, foot and mouth disease (HFMD) is a prevalent contagious childhood disease typically associated with fever, oral lesions and limb exanthema. While HFMD is caused by a plethora of serotypes of viruses under the genus Enterovirus within the Picornaviridae family, Coxsackievirus A16 (CV-A16) and Enterovirus 71 (EV-A71) are considered the main etiological agents. In recent years however, other viruses have also been isolated in considerable numbers from infected individuals in many regions, joining the legion commonly associated with HFMD. The present study investigated the cytokine and chemokine profiles of HFMD patients from Singapore and Malaysia for the first time. Comparative cohort studies of EV-A71-associated HFMD cases revealed that the Malaysia cohort had a distinct profile from the Singapore cohort, and this could be partly attributed by different EV-A71 genotypes. As the isolation of CV-A6, instead of CV-A16, had become prevalent in the Singapore cohort, it was also of particular interest to study the differential cytokine and chemokine profiles. Our data revealed that overlapping as well as unique profiles exist between the two major causative clinical isolates in the Singapore cohort. Having a better understanding of the respective immunological profiles could be useful for more accurate HFMD diagnosis, which is imperative for disease transmission control until multi-valent vaccines and/or broad-spectrum anti-viral drugs become available.
format	article
author	Fiona Mei Shan Teo Min Nyo Anng Anng Wong Natalie Woon Hui Tan Mia Tuang Koh Yoke Fun Chan Chia Yin Chong Justin Jang Hann Chu
author_facet	Fiona Mei Shan Teo Min Nyo Anng Anng Wong Natalie Woon Hui Tan Mia Tuang Koh Yoke Fun Chan Chia Yin Chong Justin Jang Hann Chu
author_sort	Fiona Mei Shan Teo
title	Cytokine and Chemokine Profiling in Patients with Hand, Foot and Mouth Disease in Singapore and Malaysia
title_short	Cytokine and Chemokine Profiling in Patients with Hand, Foot and Mouth Disease in Singapore and Malaysia
title_full	Cytokine and Chemokine Profiling in Patients with Hand, Foot and Mouth Disease in Singapore and Malaysia
title_fullStr	Cytokine and Chemokine Profiling in Patients with Hand, Foot and Mouth Disease in Singapore and Malaysia
title_full_unstemmed	Cytokine and Chemokine Profiling in Patients with Hand, Foot and Mouth Disease in Singapore and Malaysia
title_sort	cytokine and chemokine profiling in patients with hand, foot and mouth disease in singapore and malaysia
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5f9c3f12b30e48d685bfe030beea734d
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Cytokine and Chemokine Profiling in Patients with Hand, Foot and Mouth Disease in Singapore and Malaysia

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