Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis
Pro-inflammatory factors implicated for the onset of arthritis often have systematic effects, yet arthritis symptoms are mostly limited to the joints. Here the authors show that mechanical strain at the joints promotes the recruitment of monocyte and their differentiation into bone-eroding osteoclas...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2018
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/5fa215e2c56e419da80bbe7ffa24acba |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:5fa215e2c56e419da80bbe7ffa24acba |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:5fa215e2c56e419da80bbe7ffa24acba2021-12-02T16:50:05ZMechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis10.1038/s41467-018-06933-42041-1723https://doaj.org/article/5fa215e2c56e419da80bbe7ffa24acba2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06933-4https://doaj.org/toc/2041-1723Pro-inflammatory factors implicated for the onset of arthritis often have systematic effects, yet arthritis symptoms are mostly limited to the joints. Here the authors show that mechanical strain at the joints promotes the recruitment of monocyte and their differentiation into bone-eroding osteoclast to contribute this tissue specificity.Isabelle CambréDjoere GaublommeArne BurssensPeggy JacquesNadia SchryversAmélie De MuynckLeander MeurisStijn LambrechtShea CarterPieter de BleserYvan SaeysLuc Van HoorebekeGeorge KolliasMatthias MackPaul SimoensRik LoriesNico CallewaertGeorg SchettDirk ElewautNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Isabelle Cambré Djoere Gaublomme Arne Burssens Peggy Jacques Nadia Schryvers Amélie De Muynck Leander Meuris Stijn Lambrecht Shea Carter Pieter de Bleser Yvan Saeys Luc Van Hoorebeke George Kollias Matthias Mack Paul Simoens Rik Lories Nico Callewaert Georg Schett Dirk Elewaut Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis |
| description |
Pro-inflammatory factors implicated for the onset of arthritis often have systematic effects, yet arthritis symptoms are mostly limited to the joints. Here the authors show that mechanical strain at the joints promotes the recruitment of monocyte and their differentiation into bone-eroding osteoclast to contribute this tissue specificity. |
| format |
article |
| author |
Isabelle Cambré Djoere Gaublomme Arne Burssens Peggy Jacques Nadia Schryvers Amélie De Muynck Leander Meuris Stijn Lambrecht Shea Carter Pieter de Bleser Yvan Saeys Luc Van Hoorebeke George Kollias Matthias Mack Paul Simoens Rik Lories Nico Callewaert Georg Schett Dirk Elewaut |
| author_facet |
Isabelle Cambré Djoere Gaublomme Arne Burssens Peggy Jacques Nadia Schryvers Amélie De Muynck Leander Meuris Stijn Lambrecht Shea Carter Pieter de Bleser Yvan Saeys Luc Van Hoorebeke George Kollias Matthias Mack Paul Simoens Rik Lories Nico Callewaert Georg Schett Dirk Elewaut |
| author_sort |
Isabelle Cambré |
| title |
Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis |
| title_short |
Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis |
| title_full |
Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis |
| title_fullStr |
Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis |
| title_full_unstemmed |
Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis |
| title_sort |
mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/5fa215e2c56e419da80bbe7ffa24acba |
| work_keys_str_mv |
AT isabellecambre mechanicalstraindeterminesthesitespecificlocalizationofinflammationandtissuedamageinarthritis AT djoeregaublomme mechanicalstraindeterminesthesitespecificlocalizationofinflammationandtissuedamageinarthritis AT arneburssens mechanicalstraindeterminesthesitespecificlocalizationofinflammationandtissuedamageinarthritis AT peggyjacques mechanicalstraindeterminesthesitespecificlocalizationofinflammationandtissuedamageinarthritis AT nadiaschryvers mechanicalstraindeterminesthesitespecificlocalizationofinflammationandtissuedamageinarthritis AT ameliedemuynck mechanicalstraindeterminesthesitespecificlocalizationofinflammationandtissuedamageinarthritis AT leandermeuris mechanicalstraindeterminesthesitespecificlocalizationofinflammationandtissuedamageinarthritis AT stijnlambrecht mechanicalstraindeterminesthesitespecificlocalizationofinflammationandtissuedamageinarthritis AT sheacarter mechanicalstraindeterminesthesitespecificlocalizationofinflammationandtissuedamageinarthritis AT pieterdebleser mechanicalstraindeterminesthesitespecificlocalizationofinflammationandtissuedamageinarthritis AT yvansaeys mechanicalstraindeterminesthesitespecificlocalizationofinflammationandtissuedamageinarthritis AT lucvanhoorebeke mechanicalstraindeterminesthesitespecificlocalizationofinflammationandtissuedamageinarthritis AT georgekollias mechanicalstraindeterminesthesitespecificlocalizationofinflammationandtissuedamageinarthritis AT matthiasmack mechanicalstraindeterminesthesitespecificlocalizationofinflammationandtissuedamageinarthritis AT paulsimoens mechanicalstraindeterminesthesitespecificlocalizationofinflammationandtissuedamageinarthritis AT riklories mechanicalstraindeterminesthesitespecificlocalizationofinflammationandtissuedamageinarthritis AT nicocallewaert mechanicalstraindeterminesthesitespecificlocalizationofinflammationandtissuedamageinarthritis AT georgschett mechanicalstraindeterminesthesitespecificlocalizationofinflammationandtissuedamageinarthritis AT dirkelewaut mechanicalstraindeterminesthesitespecificlocalizationofinflammationandtissuedamageinarthritis |
| _version_ |
1718383102315724800 |