WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis
Uda Ho et al find that loss of centriolar scaffold protein WDR62 in mouse testis leads to defects in spermatogenesis. They find that WDR62 deficiency leads to centriole underduplication in spermatocytes and delayed manchette removal in spermatids due to delayed Katanin p80 accumulation.
Saved in:
Main Authors: | Uda Y. Ho, Chun-Wei Allen Feng, Yvonne Y. Yeap, Amanda L. Bain, Zhe Wei, Belal Shohayeb, Melissa E. Reichelt, Hayden Homer, Kum Kum Khanna, Josephine Bowles, Dominic C. H. Ng |
---|---|
Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2021
|
Subjects: | |
Online Access: | https://doaj.org/article/5fa87d30eabf4504b9c5fb5bd757b344 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Loss of Profilin3 Impairs Spermiogenesis by Affecting Acrosome Biogenesis, Autophagy, Manchette Development and Mitochondrial Organization
by: Naila Umer, et al.
Published: (2021) -
Targeting and fusion proteins during mammalian spermiogenesis
by: RAMALHO-SANTOS,JOÃO, et al.
Published: (2001) -
Modeling microcephaly with cerebral organoids reveals a WDR62–CEP170–KIF2A pathway promoting cilium disassembly in neural progenitors
by: Wei Zhang, et al.
Published: (2019) -
Coping with centriole loss: pericentriolar material maintenance after centriole degeneration
by: Carla M. C. Abreu, et al.
Published: (2021) -
Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation
by: Gaëlle Marteil, et al.
Published: (2018)