Magnitude and Associated Factors of Pulmonary Tuberculosis Among HIV/AIDS Patients Attending Antiretroviral Therapy Clinic at Debre Tabor Specialized Hospital, Northwest Ethiopia, 2019

Teklehaimanot Kiros,1 Eninur Dejen,1 Mulu Tiruneh,2 Tegenaw Tiruneh,1 Tahir Eyayu,1 Shewaneh Damtie,1 Kefyalew Amogne3 1Department of Medical Laboratory Sciences, College of Health Sciences and School of Medicine, Debre Tabor University, Debre Tabor, Ethiopia; 2Department of Social and Public Health...

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Autores principales:	Kiros T, Dejen E, Tiruneh M, Tiruneh T, Eyayu T, Damtie S, Amogne K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	art genexpert pulmonary tuberculosis predictors sputum viral load Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/5fadea9129ea49b1b9275e90f4198694
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spelling	oai:doaj.org-article:5fadea9129ea49b1b9275e90f41986942021-12-02T15:16:29ZMagnitude and Associated Factors of Pulmonary Tuberculosis Among HIV/AIDS Patients Attending Antiretroviral Therapy Clinic at Debre Tabor Specialized Hospital, Northwest Ethiopia, 20191179-1373https://doaj.org/article/5fadea9129ea49b1b9275e90f41986942020-12-01T00:00:00Zhttps://www.dovepress.com/magnitude-and-associated-factors-of-pulmonary-tuberculosis-among-hivai-peer-reviewed-article-HIVhttps://doaj.org/toc/1179-1373Teklehaimanot Kiros,1 Eninur Dejen,1 Mulu Tiruneh,2 Tegenaw Tiruneh,1 Tahir Eyayu,1 Shewaneh Damtie,1 Kefyalew Amogne3 1Department of Medical Laboratory Sciences, College of Health Sciences and School of Medicine, Debre Tabor University, Debre Tabor, Ethiopia; 2Department of Social and Public Health, College of Health Sciences and School of Medicine, Debre Tabor University, Debre Tabor, Ethiopia; 3Debre Tabor College of Health Sciences, Debre Tabor, EthiopiaCorrespondence: Teklehaimanot KirosCollege of Health Sciences and School of Medicine, Debre Tabor University, Debre Tabor, EthiopiaTel +251911009588Email tkt0932@gmail.comBackground: Tuberculosis (TB) has remained as a top global public health concern of the 21st century. It is the leading cause of morbidity and mortality among people living with human immunodeficiency virus (HIV) worldwide.Objective: The study aimed to investigate the magnitude of pulmonary tuberculosis and its associated factors among HIV-positive patients attending antiretroviral treatment (ART) clinic in Debre Tabor specialized hospital, Northwest, Ethiopia.Methods: A hospital-based cross-sectional study was conducted among 362 HIV-positive adult participants attending the ART clinic from October 1st to December 30th 2019. Socio-demographic data were collected using a pre-tested questionnaire. Sputum was collected aseptically into a sterile and leak-proof container. Following aseptic techniques, each sample was processed using the GeneXpert assay based on the manufacturer’s instructions. Similarly, about 3– 5 mL of whole blood was drawn for CD4+ T-cell count and plasma viral load tests following standard blood collection procedures. CD4+ T-cell count was performed using the BD FACS caliber flow cytometry while the plasma viral load was performed by using a quantitative real-time polymerase chain reaction. Then, collected data were double-checked, cleaned and entered into Epi-Info version 7.2.0.1 and exported to SPSS version 20.0 for further statistical analysis. The bivariate and multivariate logistic regression were conducted to address risk factor analysis. The 95%confidence interval with its corresponding cure and adjusted odds ratio was computed. Finally, p-value ≤ 0.05 was considered as a statistically significant association.Results: In this study, the overall prevalence of tuberculosis among HIV-positive patients was 18 [(5%), 95% CI: 2.8– 7.5]. A high viral load (≥ 1000 copies/mL) was positively associated [AOR (95% CI: 6.4 (1.6– 25.7)), p < 0.001] with developing tuberculosis among HIV-positive patients.Conclusion: The prevalence of TB is low among ART-receiving patients in our study site.Keywords: ART, GeneXpert, pulmonary tuberculosis, predictors, sputum, viral loadKiros TDejen ETiruneh MTiruneh TEyayu TDamtie SAmogne KDove Medical Pressarticleartgenexpertpulmonary tuberculosispredictorssputumviral loadImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol Volume 12, Pp 849-858 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	art genexpert pulmonary tuberculosis predictors sputum viral load Immunologic diseases. Allergy RC581-607
spellingShingle	art genexpert pulmonary tuberculosis predictors sputum viral load Immunologic diseases. Allergy RC581-607 Kiros T Dejen E Tiruneh M Tiruneh T Eyayu T Damtie S Amogne K Magnitude and Associated Factors of Pulmonary Tuberculosis Among HIV/AIDS Patients Attending Antiretroviral Therapy Clinic at Debre Tabor Specialized Hospital, Northwest Ethiopia, 2019
description	Teklehaimanot Kiros,1 Eninur Dejen,1 Mulu Tiruneh,2 Tegenaw Tiruneh,1 Tahir Eyayu,1 Shewaneh Damtie,1 Kefyalew Amogne3 1Department of Medical Laboratory Sciences, College of Health Sciences and School of Medicine, Debre Tabor University, Debre Tabor, Ethiopia; 2Department of Social and Public Health, College of Health Sciences and School of Medicine, Debre Tabor University, Debre Tabor, Ethiopia; 3Debre Tabor College of Health Sciences, Debre Tabor, EthiopiaCorrespondence: Teklehaimanot KirosCollege of Health Sciences and School of Medicine, Debre Tabor University, Debre Tabor, EthiopiaTel +251911009588Email tkt0932@gmail.comBackground: Tuberculosis (TB) has remained as a top global public health concern of the 21st century. It is the leading cause of morbidity and mortality among people living with human immunodeficiency virus (HIV) worldwide.Objective: The study aimed to investigate the magnitude of pulmonary tuberculosis and its associated factors among HIV-positive patients attending antiretroviral treatment (ART) clinic in Debre Tabor specialized hospital, Northwest, Ethiopia.Methods: A hospital-based cross-sectional study was conducted among 362 HIV-positive adult participants attending the ART clinic from October 1st to December 30th 2019. Socio-demographic data were collected using a pre-tested questionnaire. Sputum was collected aseptically into a sterile and leak-proof container. Following aseptic techniques, each sample was processed using the GeneXpert assay based on the manufacturer’s instructions. Similarly, about 3– 5 mL of whole blood was drawn for CD4+ T-cell count and plasma viral load tests following standard blood collection procedures. CD4+ T-cell count was performed using the BD FACS caliber flow cytometry while the plasma viral load was performed by using a quantitative real-time polymerase chain reaction. Then, collected data were double-checked, cleaned and entered into Epi-Info version 7.2.0.1 and exported to SPSS version 20.0 for further statistical analysis. The bivariate and multivariate logistic regression were conducted to address risk factor analysis. The 95%confidence interval with its corresponding cure and adjusted odds ratio was computed. Finally, p-value ≤ 0.05 was considered as a statistically significant association.Results: In this study, the overall prevalence of tuberculosis among HIV-positive patients was 18 [(5%), 95% CI: 2.8– 7.5]. A high viral load (≥ 1000 copies/mL) was positively associated [AOR (95% CI: 6.4 (1.6– 25.7)), p < 0.001] with developing tuberculosis among HIV-positive patients.Conclusion: The prevalence of TB is low among ART-receiving patients in our study site.Keywords: ART, GeneXpert, pulmonary tuberculosis, predictors, sputum, viral load
format	article
author	Kiros T Dejen E Tiruneh M Tiruneh T Eyayu T Damtie S Amogne K
author_facet	Kiros T Dejen E Tiruneh M Tiruneh T Eyayu T Damtie S Amogne K
author_sort	Kiros T
title	Magnitude and Associated Factors of Pulmonary Tuberculosis Among HIV/AIDS Patients Attending Antiretroviral Therapy Clinic at Debre Tabor Specialized Hospital, Northwest Ethiopia, 2019
title_short	Magnitude and Associated Factors of Pulmonary Tuberculosis Among HIV/AIDS Patients Attending Antiretroviral Therapy Clinic at Debre Tabor Specialized Hospital, Northwest Ethiopia, 2019
title_full	Magnitude and Associated Factors of Pulmonary Tuberculosis Among HIV/AIDS Patients Attending Antiretroviral Therapy Clinic at Debre Tabor Specialized Hospital, Northwest Ethiopia, 2019
title_fullStr	Magnitude and Associated Factors of Pulmonary Tuberculosis Among HIV/AIDS Patients Attending Antiretroviral Therapy Clinic at Debre Tabor Specialized Hospital, Northwest Ethiopia, 2019
title_full_unstemmed	Magnitude and Associated Factors of Pulmonary Tuberculosis Among HIV/AIDS Patients Attending Antiretroviral Therapy Clinic at Debre Tabor Specialized Hospital, Northwest Ethiopia, 2019
title_sort	magnitude and associated factors of pulmonary tuberculosis among hiv/aids patients attending antiretroviral therapy clinic at debre tabor specialized hospital, northwest ethiopia, 2019
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/5fadea9129ea49b1b9275e90f4198694
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Magnitude and Associated Factors of Pulmonary Tuberculosis Among HIV/AIDS Patients Attending Antiretroviral Therapy Clinic at Debre Tabor Specialized Hospital, Northwest Ethiopia, 2019

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