Impact of age and gender on the prevalence and prognostic importance of the metabolic syndrome and its components in Europeans. The MORGAM Prospective Cohort Project.

<h4>Objective</h4>To investigate the influence of age and gender on the prevalence and cardiovascular disease (CVD) risk in Europeans presenting with the Metabolic Syndrome (MetS).<h4>Methods</h4>Using 36 cohorts from the MORGAM-Project with baseline between 1982-1997, 69094...

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Autores principales:	Julie K K Vishram, Anders Borglykke, Anne H Andreasen, Jørgen Jeppesen, Hans Ibsen, Torben Jørgensen, Luigi Palmieri, Simona Giampaoli, Chiara Donfrancesco, Frank Kee, Giuseppe Mancia, Giancarlo Cesana, Kari Kuulasmaa, Veikko Salomaa, Susana Sans, Jean Ferrieres, Jean Dallongeville, Stefan Söderberg, Dominique Arveiler, Aline Wagner, Hugh Tunstall-Pedoe, Wojciech Drygas, Michael H Olsen, MORGAM Project
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5faf75e4d3f944ddb98dc001cf4e706c
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spelling	oai:doaj.org-article:5faf75e4d3f944ddb98dc001cf4e706c2021-11-25T05:59:48ZImpact of age and gender on the prevalence and prognostic importance of the metabolic syndrome and its components in Europeans. The MORGAM Prospective Cohort Project.1932-620310.1371/journal.pone.0107294https://doaj.org/article/5faf75e4d3f944ddb98dc001cf4e706c2014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0107294https://doaj.org/toc/1932-6203<h4>Objective</h4>To investigate the influence of age and gender on the prevalence and cardiovascular disease (CVD) risk in Europeans presenting with the Metabolic Syndrome (MetS).<h4>Methods</h4>Using 36 cohorts from the MORGAM-Project with baseline between 1982-1997, 69094 men and women aged 19-78 years, without known CVD, were included. During 12.2 years of follow-up, 3.7%/2.1% of men/women died due to CVD. The corresponding percentages for fatal and nonfatal coronary heart disease (CHD) and stroke were 8.3/3.8 and 3.1/2.5.<h4>Results</h4>The prevalence of MetS, according to modified definitions of the International Diabetes Federation (IDF) and the revised National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATPIII), increased across age groups for both genders (P<0.0001); with a 5-fold increase in women from ages 19-39 years to 60-78 years (7.4%/7.6% to 35.4%/37.6% for IDF/NCEP-ATPIII) and a 2-fold increase in men (5.3%/10.5% to 11.5%/21.8%). Using multivariate-adjusted Cox regressions, the associations between MetS and all three CVD events were significant (P<0.0001). For IDF/NCEP-ATPIII in men and women, hazard ratio (HR) for CHD was 1.60/1.62 and 1.93/2.03, for CVD mortality 1.73/1.65 and 1.77/2.06, and for stroke 1.51/1.53 and 1.58/1.77. Whereas in men the HRs for CVD events were independent of age (MetSage, P>0.05), in women the HRs for CHD declined with age (HRs 3.23/3.98 to 1.55/1.56; MetSage, P=0.01/P=0.001 for IDF/NCEP-ATPIII) while the HRs for stroke tended to increase (HRs 1.31/1.25 to 1.55/1.83; MetS*age, P>0.05).<h4>Conclusion</h4>In Europeans, both age and gender influenced the prevalence of MetS and its prognostic significance. The present results emphasise the importance of being critical of MetS in its current form as a marker of CVD especially in women, and advocate for a redefinition of MetS taking into account age especially in women.Julie K K VishramAnders BorglykkeAnne H AndreasenJørgen JeppesenHans IbsenTorben JørgensenLuigi PalmieriSimona GiampaoliChiara DonfrancescoFrank KeeGiuseppe ManciaGiancarlo CesanaKari KuulasmaaVeikko SalomaaSusana SansJean FerrieresJean DallongevilleStefan SöderbergDominique ArveilerAline WagnerHugh Tunstall-PedoeWojciech DrygasMichael H OlsenMORGAM ProjectPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 9, p e107294 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Julie K K Vishram Anders Borglykke Anne H Andreasen Jørgen Jeppesen Hans Ibsen Torben Jørgensen Luigi Palmieri Simona Giampaoli Chiara Donfrancesco Frank Kee Giuseppe Mancia Giancarlo Cesana Kari Kuulasmaa Veikko Salomaa Susana Sans Jean Ferrieres Jean Dallongeville Stefan Söderberg Dominique Arveiler Aline Wagner Hugh Tunstall-Pedoe Wojciech Drygas Michael H Olsen MORGAM Project Impact of age and gender on the prevalence and prognostic importance of the metabolic syndrome and its components in Europeans. The MORGAM Prospective Cohort Project.
description	<h4>Objective</h4>To investigate the influence of age and gender on the prevalence and cardiovascular disease (CVD) risk in Europeans presenting with the Metabolic Syndrome (MetS).<h4>Methods</h4>Using 36 cohorts from the MORGAM-Project with baseline between 1982-1997, 69094 men and women aged 19-78 years, without known CVD, were included. During 12.2 years of follow-up, 3.7%/2.1% of men/women died due to CVD. The corresponding percentages for fatal and nonfatal coronary heart disease (CHD) and stroke were 8.3/3.8 and 3.1/2.5.<h4>Results</h4>The prevalence of MetS, according to modified definitions of the International Diabetes Federation (IDF) and the revised National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATPIII), increased across age groups for both genders (P<0.0001); with a 5-fold increase in women from ages 19-39 years to 60-78 years (7.4%/7.6% to 35.4%/37.6% for IDF/NCEP-ATPIII) and a 2-fold increase in men (5.3%/10.5% to 11.5%/21.8%). Using multivariate-adjusted Cox regressions, the associations between MetS and all three CVD events were significant (P<0.0001). For IDF/NCEP-ATPIII in men and women, hazard ratio (HR) for CHD was 1.60/1.62 and 1.93/2.03, for CVD mortality 1.73/1.65 and 1.77/2.06, and for stroke 1.51/1.53 and 1.58/1.77. Whereas in men the HRs for CVD events were independent of age (MetSage, P>0.05), in women the HRs for CHD declined with age (HRs 3.23/3.98 to 1.55/1.56; MetSage, P=0.01/P=0.001 for IDF/NCEP-ATPIII) while the HRs for stroke tended to increase (HRs 1.31/1.25 to 1.55/1.83; MetS*age, P>0.05).<h4>Conclusion</h4>In Europeans, both age and gender influenced the prevalence of MetS and its prognostic significance. The present results emphasise the importance of being critical of MetS in its current form as a marker of CVD especially in women, and advocate for a redefinition of MetS taking into account age especially in women.
format	article
author	Julie K K Vishram Anders Borglykke Anne H Andreasen Jørgen Jeppesen Hans Ibsen Torben Jørgensen Luigi Palmieri Simona Giampaoli Chiara Donfrancesco Frank Kee Giuseppe Mancia Giancarlo Cesana Kari Kuulasmaa Veikko Salomaa Susana Sans Jean Ferrieres Jean Dallongeville Stefan Söderberg Dominique Arveiler Aline Wagner Hugh Tunstall-Pedoe Wojciech Drygas Michael H Olsen MORGAM Project
author_facet	Julie K K Vishram Anders Borglykke Anne H Andreasen Jørgen Jeppesen Hans Ibsen Torben Jørgensen Luigi Palmieri Simona Giampaoli Chiara Donfrancesco Frank Kee Giuseppe Mancia Giancarlo Cesana Kari Kuulasmaa Veikko Salomaa Susana Sans Jean Ferrieres Jean Dallongeville Stefan Söderberg Dominique Arveiler Aline Wagner Hugh Tunstall-Pedoe Wojciech Drygas Michael H Olsen MORGAM Project
author_sort	Julie K K Vishram
title	Impact of age and gender on the prevalence and prognostic importance of the metabolic syndrome and its components in Europeans. The MORGAM Prospective Cohort Project.
title_short	Impact of age and gender on the prevalence and prognostic importance of the metabolic syndrome and its components in Europeans. The MORGAM Prospective Cohort Project.
title_full	Impact of age and gender on the prevalence and prognostic importance of the metabolic syndrome and its components in Europeans. The MORGAM Prospective Cohort Project.
title_fullStr	Impact of age and gender on the prevalence and prognostic importance of the metabolic syndrome and its components in Europeans. The MORGAM Prospective Cohort Project.
title_full_unstemmed	Impact of age and gender on the prevalence and prognostic importance of the metabolic syndrome and its components in Europeans. The MORGAM Prospective Cohort Project.
title_sort	impact of age and gender on the prevalence and prognostic importance of the metabolic syndrome and its components in europeans. the morgam prospective cohort project.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/5faf75e4d3f944ddb98dc001cf4e706c
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Impact of age and gender on the prevalence and prognostic importance of the metabolic syndrome and its components in Europeans. The MORGAM Prospective Cohort Project.

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