Dysbiosis in the Human Microbiome of Cholangiocarcinoma
Cholangiocarcinoma (CCA) is the most common malignant tumor of the biliary system with a very poor prognosis. The human microbiome, which is the sum of the genetic information of human microorganisms, plays an important role in regulating the digestion, absorption, immune response, and metabolism of...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:5fb04b28d04140aa91b3f326b6d89dab2021-11-12T05:47:18ZDysbiosis in the Human Microbiome of Cholangiocarcinoma1664-042X10.3389/fphys.2021.715536https://doaj.org/article/5fb04b28d04140aa91b3f326b6d89dab2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.715536/fullhttps://doaj.org/toc/1664-042XCholangiocarcinoma (CCA) is the most common malignant tumor of the biliary system with a very poor prognosis. The human microbiome, which is the sum of the genetic information of human microorganisms, plays an important role in regulating the digestion, absorption, immune response, and metabolism of the host. Increasing evidence indicates a close relationship between CCA and the human microbiome. Specific alterations occur in the human microbiome of patients with CCA. Therefore, in this review, we aimed to summarize the recent evidence on dysbiosis in the human microbiome of CCA. Then, we generalized the effect of Helicobacter pylori on CCA. Additionally, the potential mechanism of human microbial dysbiosis promoted the progress of CCA, and its precancerous disease was also explored. Furthermore, the possibility of the human microbiome as a diagnostic and therapeutic target of CCA was discussed.Benchen RaoBenchen RaoTong RenXuemei WangXuemei WangHaiyu WangHaiyu WangYawen ZouYawen ZouYing SunYing SunShanshuo LiuShanshuo LiuZhigang RenZhigang RenZujiang YuZujiang YuFrontiers Media S.A.articlecholangiocarcinoma (CCA)human microbiomegut microbiomebile microbiomemicrobial dysbiosisPhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
cholangiocarcinoma (CCA) human microbiome gut microbiome bile microbiome microbial dysbiosis Physiology QP1-981 |
| spellingShingle |
cholangiocarcinoma (CCA) human microbiome gut microbiome bile microbiome microbial dysbiosis Physiology QP1-981 Benchen Rao Benchen Rao Tong Ren Xuemei Wang Xuemei Wang Haiyu Wang Haiyu Wang Yawen Zou Yawen Zou Ying Sun Ying Sun Shanshuo Liu Shanshuo Liu Zhigang Ren Zhigang Ren Zujiang Yu Zujiang Yu Dysbiosis in the Human Microbiome of Cholangiocarcinoma |
| description |
Cholangiocarcinoma (CCA) is the most common malignant tumor of the biliary system with a very poor prognosis. The human microbiome, which is the sum of the genetic information of human microorganisms, plays an important role in regulating the digestion, absorption, immune response, and metabolism of the host. Increasing evidence indicates a close relationship between CCA and the human microbiome. Specific alterations occur in the human microbiome of patients with CCA. Therefore, in this review, we aimed to summarize the recent evidence on dysbiosis in the human microbiome of CCA. Then, we generalized the effect of Helicobacter pylori on CCA. Additionally, the potential mechanism of human microbial dysbiosis promoted the progress of CCA, and its precancerous disease was also explored. Furthermore, the possibility of the human microbiome as a diagnostic and therapeutic target of CCA was discussed. |
| format |
article |
| author |
Benchen Rao Benchen Rao Tong Ren Xuemei Wang Xuemei Wang Haiyu Wang Haiyu Wang Yawen Zou Yawen Zou Ying Sun Ying Sun Shanshuo Liu Shanshuo Liu Zhigang Ren Zhigang Ren Zujiang Yu Zujiang Yu |
| author_facet |
Benchen Rao Benchen Rao Tong Ren Xuemei Wang Xuemei Wang Haiyu Wang Haiyu Wang Yawen Zou Yawen Zou Ying Sun Ying Sun Shanshuo Liu Shanshuo Liu Zhigang Ren Zhigang Ren Zujiang Yu Zujiang Yu |
| author_sort |
Benchen Rao |
| title |
Dysbiosis in the Human Microbiome of Cholangiocarcinoma |
| title_short |
Dysbiosis in the Human Microbiome of Cholangiocarcinoma |
| title_full |
Dysbiosis in the Human Microbiome of Cholangiocarcinoma |
| title_fullStr |
Dysbiosis in the Human Microbiome of Cholangiocarcinoma |
| title_full_unstemmed |
Dysbiosis in the Human Microbiome of Cholangiocarcinoma |
| title_sort |
dysbiosis in the human microbiome of cholangiocarcinoma |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/5fb04b28d04140aa91b3f326b6d89dab |
| work_keys_str_mv |
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