Association of serum lipopolysaccharide-binding protein level with sensitization to food allergens in children

Abstract Lipopolysaccharide (LPS)-binding protein (LBP) is an acute-phase reactant that mediates innate immune responses triggered by LPS. Recent studies indicated a positive correlation of circulating LBP level with chronic low-grade inflammation, a condition present in many non-communicable diseas...

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Autores principales:	Eun Kyo Ha, Ju Hee Kim, Dong Keon Yon, Seung Won Lee, Mi Ae Kim, Kyung Suk Lee, Myongsoon Sung, Hye Mi Jee, Youn Ho Shin, Man Yong Han
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5fb318e1d54a4f14b50802b001bad523
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spelling	oai:doaj.org-article:5fb318e1d54a4f14b50802b001bad5232021-12-02T10:48:30ZAssociation of serum lipopolysaccharide-binding protein level with sensitization to food allergens in children10.1038/s41598-020-79241-x2045-2322https://doaj.org/article/5fb318e1d54a4f14b50802b001bad5232021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79241-xhttps://doaj.org/toc/2045-2322Abstract Lipopolysaccharide (LPS)-binding protein (LBP) is an acute-phase reactant that mediates innate immune responses triggered by LPS. Recent studies indicated a positive correlation of circulating LBP level with chronic low-grade inflammation, a condition present in many non-communicable diseases. We determined the association of serum LBP concentration with allergic sensitization in a general pediatric population. Serum LBP was measured in a sample of children (n = 356; mean age = 9.6 ± 0.2 years) in this population-based cross-sectional study. Skin prick tests (SPTs) were performed to assess allergic sensitization to 22 common inhalant and food allergens. One hundred and seven children (30.1%) were nonsensitized, 160 (44.9%) were monosensitized, and 89 (25.0%) were polysensitized. Children who were mono- or polysensitized had a significantly higher median serum LBP level (25.5 ng/mL, inter-quartile range [IQR] 20.3–30.7) than those who were nonsensitized (20.3 ng/mL, IQR = 14.81–25.8, P < 0.0001). Multivariate logistic regression analysis with adjustment for confounders indicated that serum LBP level was positively associated with allergic sensitization overall (adjusted odds ratio [aOR] 1.041; 95% CI 1.007–1.076, P = 0.016), with sensitization to food allergens in particular (aOR 1.080, 95% CI 1.029–1.133, P = 0.002), but not with sensitization to aeroallergens (aOR 1.010, 95% CI 0.982–1.040, P = 0.467). LBP level was not associated with allergic diseases after adjustment. We suggest the possibility of sensitization to food allergens may be related to gut-derived low-grade inflammation, and large sized longitudinal investigations are needed to elucidate the relationship.Eun Kyo HaJu Hee KimDong Keon YonSeung Won LeeMi Ae KimKyung Suk LeeMyongsoon SungHye Mi JeeYoun Ho ShinMan Yong HanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eun Kyo Ha Ju Hee Kim Dong Keon Yon Seung Won Lee Mi Ae Kim Kyung Suk Lee Myongsoon Sung Hye Mi Jee Youn Ho Shin Man Yong Han Association of serum lipopolysaccharide-binding protein level with sensitization to food allergens in children
description	Abstract Lipopolysaccharide (LPS)-binding protein (LBP) is an acute-phase reactant that mediates innate immune responses triggered by LPS. Recent studies indicated a positive correlation of circulating LBP level with chronic low-grade inflammation, a condition present in many non-communicable diseases. We determined the association of serum LBP concentration with allergic sensitization in a general pediatric population. Serum LBP was measured in a sample of children (n = 356; mean age = 9.6 ± 0.2 years) in this population-based cross-sectional study. Skin prick tests (SPTs) were performed to assess allergic sensitization to 22 common inhalant and food allergens. One hundred and seven children (30.1%) were nonsensitized, 160 (44.9%) were monosensitized, and 89 (25.0%) were polysensitized. Children who were mono- or polysensitized had a significantly higher median serum LBP level (25.5 ng/mL, inter-quartile range [IQR] 20.3–30.7) than those who were nonsensitized (20.3 ng/mL, IQR = 14.81–25.8, P < 0.0001). Multivariate logistic regression analysis with adjustment for confounders indicated that serum LBP level was positively associated with allergic sensitization overall (adjusted odds ratio [aOR] 1.041; 95% CI 1.007–1.076, P = 0.016), with sensitization to food allergens in particular (aOR 1.080, 95% CI 1.029–1.133, P = 0.002), but not with sensitization to aeroallergens (aOR 1.010, 95% CI 0.982–1.040, P = 0.467). LBP level was not associated with allergic diseases after adjustment. We suggest the possibility of sensitization to food allergens may be related to gut-derived low-grade inflammation, and large sized longitudinal investigations are needed to elucidate the relationship.
format	article
author	Eun Kyo Ha Ju Hee Kim Dong Keon Yon Seung Won Lee Mi Ae Kim Kyung Suk Lee Myongsoon Sung Hye Mi Jee Youn Ho Shin Man Yong Han
author_facet	Eun Kyo Ha Ju Hee Kim Dong Keon Yon Seung Won Lee Mi Ae Kim Kyung Suk Lee Myongsoon Sung Hye Mi Jee Youn Ho Shin Man Yong Han
author_sort	Eun Kyo Ha
title	Association of serum lipopolysaccharide-binding protein level with sensitization to food allergens in children
title_short	Association of serum lipopolysaccharide-binding protein level with sensitization to food allergens in children
title_full	Association of serum lipopolysaccharide-binding protein level with sensitization to food allergens in children
title_fullStr	Association of serum lipopolysaccharide-binding protein level with sensitization to food allergens in children
title_full_unstemmed	Association of serum lipopolysaccharide-binding protein level with sensitization to food allergens in children
title_sort	association of serum lipopolysaccharide-binding protein level with sensitization to food allergens in children
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5fb318e1d54a4f14b50802b001bad523
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Association of serum lipopolysaccharide-binding protein level with sensitization to food allergens in children

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