Immunomodulatory and antioxidant effects of total flavonoids of Spatholobus suberectus Dunn on PCV2 infected mice

Abstract Oxidative stress plays an important role in the pathogenesis of virus infection and antioxidants are becoming promising candidates as therapeutic agents. This study is designed to investigate the effect of total flavonoids of Spatholobus suberectus Dunn (TFSD) on oxidative stress in mice in...

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Autores principales:	Yuan-fang Fu, Li-he Jiang, Wei-dan Zhao, Meng Xi-nan, Shi-qi Huang, Jian Yang, Ting-jun Hu, Hai-lan Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5fb6f75be3eb433993a5e241c7c28c9d
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spelling	oai:doaj.org-article:5fb6f75be3eb433993a5e241c7c28c9d2021-12-02T16:06:03ZImmunomodulatory and antioxidant effects of total flavonoids of Spatholobus suberectus Dunn on PCV2 infected mice10.1038/s41598-017-09340-92045-2322https://doaj.org/article/5fb6f75be3eb433993a5e241c7c28c9d2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09340-9https://doaj.org/toc/2045-2322Abstract Oxidative stress plays an important role in the pathogenesis of virus infection and antioxidants are becoming promising candidates as therapeutic agents. This study is designed to investigate the effect of total flavonoids of Spatholobus suberectus Dunn (TFSD) on oxidative stress in mice induced by porcine circovirus type 2 (PCV2) infection. The PCV2 infection leads to significant decrease in thymus and spleen indices, elevation of xanthine oxidase (XOD) and myeloperoxidase (MPO) activities, reduction in GSH level and GSH to GSSG ratio and decline of superoxide dismutase (SOD) activity, indicating the formation of immunosuppression and oxidative stress. TFSD treatment recovered the alteration of viscera index, antioxidant content and activities of oxidative-associated enzymes to a level similar to control. Our findings suggested that PCV2 induced immunosuppression and oxidative stress in mice and TFSD might be able to protect animals from virus infection via regulation of immune function and inhibition of oxidative stress.Yuan-fang FuLi-he JiangWei-dan ZhaoMeng Xi-nanShi-qi HuangJian YangTing-jun HuHai-lan ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuan-fang Fu Li-he Jiang Wei-dan Zhao Meng Xi-nan Shi-qi Huang Jian Yang Ting-jun Hu Hai-lan Chen Immunomodulatory and antioxidant effects of total flavonoids of Spatholobus suberectus Dunn on PCV2 infected mice
description	Abstract Oxidative stress plays an important role in the pathogenesis of virus infection and antioxidants are becoming promising candidates as therapeutic agents. This study is designed to investigate the effect of total flavonoids of Spatholobus suberectus Dunn (TFSD) on oxidative stress in mice induced by porcine circovirus type 2 (PCV2) infection. The PCV2 infection leads to significant decrease in thymus and spleen indices, elevation of xanthine oxidase (XOD) and myeloperoxidase (MPO) activities, reduction in GSH level and GSH to GSSG ratio and decline of superoxide dismutase (SOD) activity, indicating the formation of immunosuppression and oxidative stress. TFSD treatment recovered the alteration of viscera index, antioxidant content and activities of oxidative-associated enzymes to a level similar to control. Our findings suggested that PCV2 induced immunosuppression and oxidative stress in mice and TFSD might be able to protect animals from virus infection via regulation of immune function and inhibition of oxidative stress.
format	article
author	Yuan-fang Fu Li-he Jiang Wei-dan Zhao Meng Xi-nan Shi-qi Huang Jian Yang Ting-jun Hu Hai-lan Chen
author_facet	Yuan-fang Fu Li-he Jiang Wei-dan Zhao Meng Xi-nan Shi-qi Huang Jian Yang Ting-jun Hu Hai-lan Chen
author_sort	Yuan-fang Fu
title	Immunomodulatory and antioxidant effects of total flavonoids of Spatholobus suberectus Dunn on PCV2 infected mice
title_short	Immunomodulatory and antioxidant effects of total flavonoids of Spatholobus suberectus Dunn on PCV2 infected mice
title_full	Immunomodulatory and antioxidant effects of total flavonoids of Spatholobus suberectus Dunn on PCV2 infected mice
title_fullStr	Immunomodulatory and antioxidant effects of total flavonoids of Spatholobus suberectus Dunn on PCV2 infected mice
title_full_unstemmed	Immunomodulatory and antioxidant effects of total flavonoids of Spatholobus suberectus Dunn on PCV2 infected mice
title_sort	immunomodulatory and antioxidant effects of total flavonoids of spatholobus suberectus dunn on pcv2 infected mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5fb6f75be3eb433993a5e241c7c28c9d
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Immunomodulatory and antioxidant effects of total flavonoids of Spatholobus suberectus Dunn on PCV2 infected mice

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