Respective prognostic value of genomic grade and histological proliferation markers in early stage (pN0) breast carcinoma.

<h4>Background</h4>Genomic grade (GG) is a 97-gene signature which improves the accuracy and prognostic value of histological grade (HG) in invasive breast carcinoma. Since most of the genes included in the GG are involved in cell proliferation, we performed a retrospective study to comp...

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Autores principales:	Fabien Reyal, Marc A Bollet, Martial Caly, David Gentien, Sabrina Carpentier, Hélène Peyro-Saint-Paul, Jean-Yves Pierga, Paul Cottu, Véronique Dieras, Brigitte Sigal-Zafrani, Anne Vincent-Salomon, Xavier Sastre-Garau
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5fb78c25da984a5aac970b7d17abc3eb
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spelling	oai:doaj.org-article:5fb78c25da984a5aac970b7d17abc3eb2021-11-18T07:21:46ZRespective prognostic value of genomic grade and histological proliferation markers in early stage (pN0) breast carcinoma.1932-620310.1371/journal.pone.0035184https://doaj.org/article/5fb78c25da984a5aac970b7d17abc3eb2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22529987/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Genomic grade (GG) is a 97-gene signature which improves the accuracy and prognostic value of histological grade (HG) in invasive breast carcinoma. Since most of the genes included in the GG are involved in cell proliferation, we performed a retrospective study to compare the prognostic value of GG, Mitotic Index and Ki67 score.<h4>Methods</h4>A series of 163 consecutive breast cancers was retained (pT1-2, pN0, pM0, 10-yr follow-up). GG was computed using MapQuant Dx(R).<h4>Results</h4>GG was low (GG-1) in 48%, high (GG-3) in 31% and equivocal in 21% of cases. For HG-2 tumors, 50% were classified as GG-1, 18% as GG-3 whereas 31% remained equivocal. In a subgroup of 132 ER+/HER2- tumors GG was the most significant prognostic factor in multivariate Cox regression analysis adjusted for age and tumor size (HR = 5.23, p = 0.02).<h4>Conclusions</h4>In a reference comprehensive cancer center setting, compared to histological grade, GG added significant information on cell proliferation in breast cancers. In patients with HG-2 carcinoma, applying the GG to guide the treatment scheme could lead to a reduction in adjuvant therapy prescription. However, based on the results observed and considering (i) the relatively close prognostic values of GG and Ki67, (ii) the reclassification of about 30% of HG-2 tumors as Equivocal GG and (iii) the economical and technical requirements of the MapQuant micro-array GG test, the availability in the near future of a PCR-based Genomic Grade test with improved performances may lead to an introduction in clinical routine of this test for histological grade 2, ER positive, HER2 negative breast carcinoma.Fabien ReyalMarc A BolletMartial CalyDavid GentienSabrina CarpentierHélène Peyro-Saint-PaulJean-Yves PiergaPaul CottuVéronique DierasBrigitte Sigal-ZafraniAnne Vincent-SalomonXavier Sastre-GarauPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 4, p e35184 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fabien Reyal Marc A Bollet Martial Caly David Gentien Sabrina Carpentier Hélène Peyro-Saint-Paul Jean-Yves Pierga Paul Cottu Véronique Dieras Brigitte Sigal-Zafrani Anne Vincent-Salomon Xavier Sastre-Garau Respective prognostic value of genomic grade and histological proliferation markers in early stage (pN0) breast carcinoma.
description	<h4>Background</h4>Genomic grade (GG) is a 97-gene signature which improves the accuracy and prognostic value of histological grade (HG) in invasive breast carcinoma. Since most of the genes included in the GG are involved in cell proliferation, we performed a retrospective study to compare the prognostic value of GG, Mitotic Index and Ki67 score.<h4>Methods</h4>A series of 163 consecutive breast cancers was retained (pT1-2, pN0, pM0, 10-yr follow-up). GG was computed using MapQuant Dx(R).<h4>Results</h4>GG was low (GG-1) in 48%, high (GG-3) in 31% and equivocal in 21% of cases. For HG-2 tumors, 50% were classified as GG-1, 18% as GG-3 whereas 31% remained equivocal. In a subgroup of 132 ER+/HER2- tumors GG was the most significant prognostic factor in multivariate Cox regression analysis adjusted for age and tumor size (HR = 5.23, p = 0.02).<h4>Conclusions</h4>In a reference comprehensive cancer center setting, compared to histological grade, GG added significant information on cell proliferation in breast cancers. In patients with HG-2 carcinoma, applying the GG to guide the treatment scheme could lead to a reduction in adjuvant therapy prescription. However, based on the results observed and considering (i) the relatively close prognostic values of GG and Ki67, (ii) the reclassification of about 30% of HG-2 tumors as Equivocal GG and (iii) the economical and technical requirements of the MapQuant micro-array GG test, the availability in the near future of a PCR-based Genomic Grade test with improved performances may lead to an introduction in clinical routine of this test for histological grade 2, ER positive, HER2 negative breast carcinoma.
format	article
author	Fabien Reyal Marc A Bollet Martial Caly David Gentien Sabrina Carpentier Hélène Peyro-Saint-Paul Jean-Yves Pierga Paul Cottu Véronique Dieras Brigitte Sigal-Zafrani Anne Vincent-Salomon Xavier Sastre-Garau
author_facet	Fabien Reyal Marc A Bollet Martial Caly David Gentien Sabrina Carpentier Hélène Peyro-Saint-Paul Jean-Yves Pierga Paul Cottu Véronique Dieras Brigitte Sigal-Zafrani Anne Vincent-Salomon Xavier Sastre-Garau
author_sort	Fabien Reyal
title	Respective prognostic value of genomic grade and histological proliferation markers in early stage (pN0) breast carcinoma.
title_short	Respective prognostic value of genomic grade and histological proliferation markers in early stage (pN0) breast carcinoma.
title_full	Respective prognostic value of genomic grade and histological proliferation markers in early stage (pN0) breast carcinoma.
title_fullStr	Respective prognostic value of genomic grade and histological proliferation markers in early stage (pN0) breast carcinoma.
title_full_unstemmed	Respective prognostic value of genomic grade and histological proliferation markers in early stage (pN0) breast carcinoma.
title_sort	respective prognostic value of genomic grade and histological proliferation markers in early stage (pn0) breast carcinoma.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/5fb78c25da984a5aac970b7d17abc3eb
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Respective prognostic value of genomic grade and histological proliferation markers in early stage (pN0) breast carcinoma.

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