Oxidative Stress in the Pathogenesis of Antiphospholipid Syndrome: Implications for the Atherothrombotic Process

Atherothrombosis is a frequent complication of the clinical history of patients with antiphospholipid syndrome (APS). Both atherothrombosis and APS are characterized by increased oxidative stress. Oxidative modifications are implicated in the formation of antiphospholipid antibodies, which in turn m...

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Autores principales:	Cristina Nocella, Simona Bartimoccia, Vittoria Cammisotto, Alessandra D’Amico, Daniele Pastori, Giacomo Frati, Sebastiano Sciarretta, Paolo Rosa, Chiara Felici, Oliviero Riggio, Antonella Calogero, Roberto Carnevale, SMiLe Group
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	oxidative stress thrombosis antiphospholipid syndrome antioxidant treatment Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/5fb7f318c7aa41db855ce0f9a17aad4c
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spelling	oai:doaj.org-article:5fb7f318c7aa41db855ce0f9a17aad4c2021-11-25T16:28:38ZOxidative Stress in the Pathogenesis of Antiphospholipid Syndrome: Implications for the Atherothrombotic Process10.3390/antiox101117902076-3921https://doaj.org/article/5fb7f318c7aa41db855ce0f9a17aad4c2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1790https://doaj.org/toc/2076-3921Atherothrombosis is a frequent complication of the clinical history of patients with antiphospholipid syndrome (APS). Both atherothrombosis and APS are characterized by increased oxidative stress. Oxidative modifications are implicated in the formation of antiphospholipid antibodies, which in turn may favour the oxidative imbalance by increasing the production of reactive oxidant species (ROS) or by a direct interaction with pro-oxidant/antioxidant enzymes. As a result of these processes, APS patients suffer from an oxidative imbalance that may contribute to the progression of the atherosclerotic process and to the onset of ischemic thrombotic complications. The aim of this review is to describe mechanisms implicated in the formation of ROS in APS patients and their involvement in the atherothrombotic process. We also provide an overview of potential therapeutic approaches to blunt oxidative stress and to prevent atherothrombotic complications in these patients.Cristina NocellaSimona BartimocciaVittoria CammisottoAlessandra D’AmicoDaniele PastoriGiacomo FratiSebastiano SciarrettaPaolo RosaChiara FeliciOliviero RiggioAntonella CalogeroRoberto CarnevaleSMiLe GroupMDPI AGarticleoxidative stressthrombosisantiphospholipid syndromeantioxidant treatmentTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1790, p 1790 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	oxidative stress thrombosis antiphospholipid syndrome antioxidant treatment Therapeutics. Pharmacology RM1-950
spellingShingle	oxidative stress thrombosis antiphospholipid syndrome antioxidant treatment Therapeutics. Pharmacology RM1-950 Cristina Nocella Simona Bartimoccia Vittoria Cammisotto Alessandra D’Amico Daniele Pastori Giacomo Frati Sebastiano Sciarretta Paolo Rosa Chiara Felici Oliviero Riggio Antonella Calogero Roberto Carnevale SMiLe Group Oxidative Stress in the Pathogenesis of Antiphospholipid Syndrome: Implications for the Atherothrombotic Process
description	Atherothrombosis is a frequent complication of the clinical history of patients with antiphospholipid syndrome (APS). Both atherothrombosis and APS are characterized by increased oxidative stress. Oxidative modifications are implicated in the formation of antiphospholipid antibodies, which in turn may favour the oxidative imbalance by increasing the production of reactive oxidant species (ROS) or by a direct interaction with pro-oxidant/antioxidant enzymes. As a result of these processes, APS patients suffer from an oxidative imbalance that may contribute to the progression of the atherosclerotic process and to the onset of ischemic thrombotic complications. The aim of this review is to describe mechanisms implicated in the formation of ROS in APS patients and their involvement in the atherothrombotic process. We also provide an overview of potential therapeutic approaches to blunt oxidative stress and to prevent atherothrombotic complications in these patients.
format	article
author	Cristina Nocella Simona Bartimoccia Vittoria Cammisotto Alessandra D’Amico Daniele Pastori Giacomo Frati Sebastiano Sciarretta Paolo Rosa Chiara Felici Oliviero Riggio Antonella Calogero Roberto Carnevale SMiLe Group
author_facet	Cristina Nocella Simona Bartimoccia Vittoria Cammisotto Alessandra D’Amico Daniele Pastori Giacomo Frati Sebastiano Sciarretta Paolo Rosa Chiara Felici Oliviero Riggio Antonella Calogero Roberto Carnevale SMiLe Group
author_sort	Cristina Nocella
title	Oxidative Stress in the Pathogenesis of Antiphospholipid Syndrome: Implications for the Atherothrombotic Process
title_short	Oxidative Stress in the Pathogenesis of Antiphospholipid Syndrome: Implications for the Atherothrombotic Process
title_full	Oxidative Stress in the Pathogenesis of Antiphospholipid Syndrome: Implications for the Atherothrombotic Process
title_fullStr	Oxidative Stress in the Pathogenesis of Antiphospholipid Syndrome: Implications for the Atherothrombotic Process
title_full_unstemmed	Oxidative Stress in the Pathogenesis of Antiphospholipid Syndrome: Implications for the Atherothrombotic Process
title_sort	oxidative stress in the pathogenesis of antiphospholipid syndrome: implications for the atherothrombotic process
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5fb7f318c7aa41db855ce0f9a17aad4c
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Oxidative Stress in the Pathogenesis of Antiphospholipid Syndrome: Implications for the Atherothrombotic Process

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