nr3c1 null mutant zebrafish are viable and reveal DNA-binding-independent activities of the glucocorticoid receptor

Abstract Glucocorticoids (GCs) play important roles in developmental and physiological processes through the transcriptional activity of their cognate receptor (Gr). Using CRISPR/Cas9 technology, we established a zebrafish null Gr mutant line and compared its phenotypes with wild type and a zebrafis...

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Autores principales: N. Facchinello, T. Skobo, G. Meneghetti, E. Colletti, A. Dinarello, N. Tiso, R. Costa, G. Gioacchini, O. Carnevali, F. Argenton, L. Colombo, L. Dalla Valle
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/5fc0ac8c9079415a80ca8b2300792049
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