Hyperbaric oxygen therapy as a potential treatment for post-traumatic stress disorder associated with traumatic brain injury

David J Eve,1 Martin R Steele,2 Paul R Sanberg,1 Cesar V Borlongan1 1Department of Neurosurgery and Brain Repair, Center of Excellence for Aging and Brain Repair, Morsani College of Medicine, 2Veterans Reintegration Steering Committee, Veterans Research, University of South Florida, Tampa, FL, USA...

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Autores principales:	Eve DJ, Steele MR, Sanberg PR, Borlongan CV
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	traumatic brain injury post-traumatic stress disorder hyperbaric oxygen therapy preconditioning inflammation acute and chronic treatment. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/5fc13c6dcff0492991541a01743063e1
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spelling	oai:doaj.org-article:5fc13c6dcff0492991541a01743063e12021-12-02T01:48:15ZHyperbaric oxygen therapy as a potential treatment for post-traumatic stress disorder associated with traumatic brain injury1178-2021https://doaj.org/article/5fc13c6dcff0492991541a01743063e12016-10-01T00:00:00Zhttps://www.dovepress.com/hyperbaric-oxygen-therapy-as-a-potential-treatment-for-post-traumatic--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021David J Eve,1 Martin R Steele,2 Paul R Sanberg,1 Cesar V Borlongan1 1Department of Neurosurgery and Brain Repair, Center of Excellence for Aging and Brain Repair, Morsani College of Medicine, 2Veterans Reintegration Steering Committee, Veterans Research, University of South Florida, Tampa, FL, USA Abstract: Traumatic brain injury (TBI) describes the presence of physical damage to the brain as a consequence of an insult and frequently possesses psychological and neurological symptoms depending on the severity of the injury. The recent increased military presence of US troops in Iraq and Afghanistan has coincided with greater use of improvised exploding devices, resulting in many returning soldiers suffering from some degree of TBI. A biphasic response is observed which is first directly injury-related, and second due to hypoxia, increased oxidative stress, and inflammation. A proportion of the returning soldiers also suffer from post-traumatic stress disorder (PTSD), and in some cases, this may be a consequence of TBI. Effective treatments are still being identified, and a possible therapeutic candidate is hyperbaric oxygen therapy (HBOT). Some clinical trials have been performed which suggest benefits with regard to survival and disease severity of TBI and/or PTSD, while several other studies do not see any improvement compared to a possibly poorly controlled sham. HBOT has been shown to reduce apoptosis, upregulate growth factors, promote antioxidant levels, and inhibit inflammatory cytokines in animal models, and hence, it is likely that HBOT could be advantageous in treating at least the secondary phase of TBI and PTSD. There is some evidence of a putative prophylactic or preconditioning benefit of HBOT exposure in animal models of brain injury, and the optimal time frame for treatment is yet to be determined. HBOT has potential side effects such as acute cerebral toxicity and more reactive oxygen species with long-term use, and therefore, optimizing exposure duration to maximize the reward and decrease the detrimental effects of HBOT is necessary. This review provides a summary of the current understanding of HBOT as well as suggests future directions including prophylactic use and chronic treatment. Keywords: mild moderate and severe TBI, clinical trials, reactive oxygen species, acoustic startle response, elevated plus maze, cutoff behavioral criteria, prophylactic use, preconditioning, inflammation, acute and chronic treatmentEve DJSteele MRSanberg PRBorlongan CVDove Medical Pressarticletraumatic brain injurypost-traumatic stress disorderhyperbaric oxygen therapypreconditioninginflammationacute and chronic treatment.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 12, Pp 2689-2705 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	traumatic brain injury post-traumatic stress disorder hyperbaric oxygen therapy preconditioning inflammation acute and chronic treatment. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	traumatic brain injury post-traumatic stress disorder hyperbaric oxygen therapy preconditioning inflammation acute and chronic treatment. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Eve DJ Steele MR Sanberg PR Borlongan CV Hyperbaric oxygen therapy as a potential treatment for post-traumatic stress disorder associated with traumatic brain injury
description	David J Eve,1 Martin R Steele,2 Paul R Sanberg,1 Cesar V Borlongan1 1Department of Neurosurgery and Brain Repair, Center of Excellence for Aging and Brain Repair, Morsani College of Medicine, 2Veterans Reintegration Steering Committee, Veterans Research, University of South Florida, Tampa, FL, USA Abstract: Traumatic brain injury (TBI) describes the presence of physical damage to the brain as a consequence of an insult and frequently possesses psychological and neurological symptoms depending on the severity of the injury. The recent increased military presence of US troops in Iraq and Afghanistan has coincided with greater use of improvised exploding devices, resulting in many returning soldiers suffering from some degree of TBI. A biphasic response is observed which is first directly injury-related, and second due to hypoxia, increased oxidative stress, and inflammation. A proportion of the returning soldiers also suffer from post-traumatic stress disorder (PTSD), and in some cases, this may be a consequence of TBI. Effective treatments are still being identified, and a possible therapeutic candidate is hyperbaric oxygen therapy (HBOT). Some clinical trials have been performed which suggest benefits with regard to survival and disease severity of TBI and/or PTSD, while several other studies do not see any improvement compared to a possibly poorly controlled sham. HBOT has been shown to reduce apoptosis, upregulate growth factors, promote antioxidant levels, and inhibit inflammatory cytokines in animal models, and hence, it is likely that HBOT could be advantageous in treating at least the secondary phase of TBI and PTSD. There is some evidence of a putative prophylactic or preconditioning benefit of HBOT exposure in animal models of brain injury, and the optimal time frame for treatment is yet to be determined. HBOT has potential side effects such as acute cerebral toxicity and more reactive oxygen species with long-term use, and therefore, optimizing exposure duration to maximize the reward and decrease the detrimental effects of HBOT is necessary. This review provides a summary of the current understanding of HBOT as well as suggests future directions including prophylactic use and chronic treatment. Keywords: mild moderate and severe TBI, clinical trials, reactive oxygen species, acoustic startle response, elevated plus maze, cutoff behavioral criteria, prophylactic use, preconditioning, inflammation, acute and chronic treatment
format	article
author	Eve DJ Steele MR Sanberg PR Borlongan CV
author_facet	Eve DJ Steele MR Sanberg PR Borlongan CV
author_sort	Eve DJ
title	Hyperbaric oxygen therapy as a potential treatment for post-traumatic stress disorder associated with traumatic brain injury
title_short	Hyperbaric oxygen therapy as a potential treatment for post-traumatic stress disorder associated with traumatic brain injury
title_full	Hyperbaric oxygen therapy as a potential treatment for post-traumatic stress disorder associated with traumatic brain injury
title_fullStr	Hyperbaric oxygen therapy as a potential treatment for post-traumatic stress disorder associated with traumatic brain injury
title_full_unstemmed	Hyperbaric oxygen therapy as a potential treatment for post-traumatic stress disorder associated with traumatic brain injury
title_sort	hyperbaric oxygen therapy as a potential treatment for post-traumatic stress disorder associated with traumatic brain injury
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/5fc13c6dcff0492991541a01743063e1
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Hyperbaric oxygen therapy as a potential treatment for post-traumatic stress disorder associated with traumatic brain injury

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