Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming

Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming

Understanding how regulators of inflammation affect nucleic acid sensing is important for targeting research against inflammatory diseases and conditions. Here, the authors identify Nrf2 as an important negative regulator of STING and suggest a link between metabolic reprogramming and antiviral cyto...

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Autores principales: David Olagnier, Aske M. Brandtoft, Camilla Gunderstofte, Nikolaj L. Villadsen, Christian Krapp, Anne L. Thielke, Anders Laustsen, Suraj Peri, Anne Louise Hansen, Lene Bonefeld, Jacob Thyrsted, Victor Bruun, Marie B. Iversen, Lin Lin, Virginia M. Artegoitia, Chenhe Su, Long Yang, Rongtuan Lin, Siddharth Balachandran, Yonglun Luo, Mette Nyegaard, Bernadette Marrero, Raphaela Goldbach-Mansky, Mona Motwani, Dylan G. Ryan, Katherine A. Fitzgerald, Luke A. O’Neill, Anne K. Hollensen, Christian K. Damgaard, Frank v. de Paoli, Hanne C. Bertram, Martin R. Jakobsen, Thomas B. Poulsen, Christian K. Holm
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/5fc54bf6fbd8427c94401b47231854b6
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spelling oai:doaj.org-article:5fc54bf6fbd8427c94401b47231854b62021-12-02T16:49:23ZNrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming10.1038/s41467-018-05861-72041-1723https://doaj.org/article/5fc54bf6fbd8427c94401b47231854b62018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05861-7https://doaj.org/toc/2041-1723Understanding how regulators of inflammation affect nucleic acid sensing is important for targeting research against inflammatory diseases and conditions. Here, the authors identify Nrf2 as an important negative regulator of STING and suggest a link between metabolic reprogramming and antiviral cytosolic DNA sensing in human cells.David OlagnierAske M. BrandtoftCamilla GunderstofteNikolaj L. VilladsenChristian KrappAnne L. ThielkeAnders LaustsenSuraj PeriAnne Louise HansenLene BonefeldJacob ThyrstedVictor BruunMarie B. IversenLin LinVirginia M. ArtegoitiaChenhe SuLong YangRongtuan LinSiddharth BalachandranYonglun LuoMette NyegaardBernadette MarreroRaphaela Goldbach-ManskyMona MotwaniDylan G. RyanKatherine A. FitzgeraldLuke A. O’NeillAnne K. HollensenChristian K. DamgaardFrank v. de PaoliHanne C. BertramMartin R. JakobsenThomas B. PoulsenChristian K. HolmNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
David Olagnier
Aske M. Brandtoft
Camilla Gunderstofte
Nikolaj L. Villadsen
Christian Krapp
Anne L. Thielke
Anders Laustsen
Suraj Peri
Anne Louise Hansen
Lene Bonefeld
Jacob Thyrsted
Victor Bruun
Marie B. Iversen
Lin Lin
Virginia M. Artegoitia
Chenhe Su
Long Yang
Rongtuan Lin
Siddharth Balachandran
Yonglun Luo
Mette Nyegaard
Bernadette Marrero
Raphaela Goldbach-Mansky
Mona Motwani
Dylan G. Ryan
Katherine A. Fitzgerald
Luke A. O’Neill
Anne K. Hollensen
Christian K. Damgaard
Frank v. de Paoli
Hanne C. Bertram
Martin R. Jakobsen
Thomas B. Poulsen
Christian K. Holm
Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming
description Understanding how regulators of inflammation affect nucleic acid sensing is important for targeting research against inflammatory diseases and conditions. Here, the authors identify Nrf2 as an important negative regulator of STING and suggest a link between metabolic reprogramming and antiviral cytosolic DNA sensing in human cells.
format article
author David Olagnier
Aske M. Brandtoft
Camilla Gunderstofte
Nikolaj L. Villadsen
Christian Krapp
Anne L. Thielke
Anders Laustsen
Suraj Peri
Anne Louise Hansen
Lene Bonefeld
Jacob Thyrsted
Victor Bruun
Marie B. Iversen
Lin Lin
Virginia M. Artegoitia
Chenhe Su
Long Yang
Rongtuan Lin
Siddharth Balachandran
Yonglun Luo
Mette Nyegaard
Bernadette Marrero
Raphaela Goldbach-Mansky
Mona Motwani
Dylan G. Ryan
Katherine A. Fitzgerald
Luke A. O’Neill
Anne K. Hollensen
Christian K. Damgaard
Frank v. de Paoli
Hanne C. Bertram
Martin R. Jakobsen
Thomas B. Poulsen
Christian K. Holm
author_facet David Olagnier
Aske M. Brandtoft
Camilla Gunderstofte
Nikolaj L. Villadsen
Christian Krapp
Anne L. Thielke
Anders Laustsen
Suraj Peri
Anne Louise Hansen
Lene Bonefeld
Jacob Thyrsted
Victor Bruun
Marie B. Iversen
Lin Lin
Virginia M. Artegoitia
Chenhe Su
Long Yang
Rongtuan Lin
Siddharth Balachandran
Yonglun Luo
Mette Nyegaard
Bernadette Marrero
Raphaela Goldbach-Mansky
Mona Motwani
Dylan G. Ryan
Katherine A. Fitzgerald
Luke A. O’Neill
Anne K. Hollensen
Christian K. Damgaard
Frank v. de Paoli
Hanne C. Bertram
Martin R. Jakobsen
Thomas B. Poulsen
Christian K. Holm
author_sort David Olagnier
title Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming
title_short Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming
title_full Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming
title_fullStr Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming
title_full_unstemmed Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming
title_sort nrf2 negatively regulates sting indicating a link between antiviral sensing and metabolic reprogramming
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/5fc54bf6fbd8427c94401b47231854b6
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