Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism

Histone acetylations are important epigenetic marks for transcriptional activation and respond to metabolic changes. Here the authors develop a lifespan screen and show that inactivation of the histone deacetylase complex activates longevity and protects against stress via trehalose metabolism.

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Autores principales:	Ruofan Yu, Xiaohua Cao, Luyang Sun, Jun-yi Zhu, Brian M Wasko, Wei Liu, Emeline Crutcher, Haiying Liu, Myeong Chan Jo, Lidong Qin, Matt Kaeberlein, Zhe Han, Weiwei Dang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5fc58828c7fb441ca6310e633e6239e1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:5fc58828c7fb441ca6310e633e6239e12021-12-02T14:25:02ZInactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism10.1038/s41467-021-22257-22041-1723https://doaj.org/article/5fc58828c7fb441ca6310e633e6239e12021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22257-2https://doaj.org/toc/2041-1723Histone acetylations are important epigenetic marks for transcriptional activation and respond to metabolic changes. Here the authors develop a lifespan screen and show that inactivation of the histone deacetylase complex activates longevity and protects against stress via trehalose metabolism.Ruofan YuXiaohua CaoLuyang SunJun-yi ZhuBrian M WaskoWei LiuEmeline CrutcherHaiying LiuMyeong Chan JoLidong QinMatt KaeberleinZhe HanWeiwei DangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ruofan Yu Xiaohua Cao Luyang Sun Jun-yi Zhu Brian M Wasko Wei Liu Emeline Crutcher Haiying Liu Myeong Chan Jo Lidong Qin Matt Kaeberlein Zhe Han Weiwei Dang Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism
description	Histone acetylations are important epigenetic marks for transcriptional activation and respond to metabolic changes. Here the authors develop a lifespan screen and show that inactivation of the histone deacetylase complex activates longevity and protects against stress via trehalose metabolism.
format	article
author	Ruofan Yu Xiaohua Cao Luyang Sun Jun-yi Zhu Brian M Wasko Wei Liu Emeline Crutcher Haiying Liu Myeong Chan Jo Lidong Qin Matt Kaeberlein Zhe Han Weiwei Dang
author_facet	Ruofan Yu Xiaohua Cao Luyang Sun Jun-yi Zhu Brian M Wasko Wei Liu Emeline Crutcher Haiying Liu Myeong Chan Jo Lidong Qin Matt Kaeberlein Zhe Han Weiwei Dang
author_sort	Ruofan Yu
title	Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism
title_short	Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism
title_full	Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism
title_fullStr	Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism
title_full_unstemmed	Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism
title_sort	inactivating histone deacetylase hda promotes longevity by mobilizing trehalose metabolism
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5fc58828c7fb441ca6310e633e6239e1
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Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism

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