LECT2 drives haematopoietic stem cell expansion and mobilization via regulating the macrophages and osteolineage cells

LECT2 drives haematopoietic stem cell expansion and mobilization via regulating the macrophages and osteolineage cells

How extramedullar cytokines regulate hematopoietic stem cell (HSC) homeostasis is unclear. Here, the authors show that the cytokine leukocyte cell-derived chemotaxin 2 regulates HSC expansion and mobilisation via tumour necrosis factor and interaction with CD209a in macrophages.

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Autores principales: Xin-Jiang Lu, Qiang Chen, Ye-Jing Rong, Guan-Jun Yang, Chang-Hong Li, Ning-Yi Xu, Chao-Hui Yu, Hui-Ying Wang, Shun Zhang, Yu-Hong Shi, Jiong Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/5fc69ea1db63499d875bc68599c36908
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spelling oai:doaj.org-article:5fc69ea1db63499d875bc68599c369082021-12-02T17:33:08ZLECT2 drives haematopoietic stem cell expansion and mobilization via regulating the macrophages and osteolineage cells10.1038/ncomms127192041-1723https://doaj.org/article/5fc69ea1db63499d875bc68599c369082016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12719https://doaj.org/toc/2041-1723How extramedullar cytokines regulate hematopoietic stem cell (HSC) homeostasis is unclear. Here, the authors show that the cytokine leukocyte cell-derived chemotaxin 2 regulates HSC expansion and mobilisation via tumour necrosis factor and interaction with CD209a in macrophages.Xin-Jiang LuQiang ChenYe-Jing RongGuan-Jun YangChang-Hong LiNing-Yi XuChao-Hui YuHui-Ying WangShun ZhangYu-Hong ShiJiong ChenNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xin-Jiang Lu
Qiang Chen
Ye-Jing Rong
Guan-Jun Yang
Chang-Hong Li
Ning-Yi Xu
Chao-Hui Yu
Hui-Ying Wang
Shun Zhang
Yu-Hong Shi
Jiong Chen
LECT2 drives haematopoietic stem cell expansion and mobilization via regulating the macrophages and osteolineage cells
description How extramedullar cytokines regulate hematopoietic stem cell (HSC) homeostasis is unclear. Here, the authors show that the cytokine leukocyte cell-derived chemotaxin 2 regulates HSC expansion and mobilisation via tumour necrosis factor and interaction with CD209a in macrophages.
format article
author Xin-Jiang Lu
Qiang Chen
Ye-Jing Rong
Guan-Jun Yang
Chang-Hong Li
Ning-Yi Xu
Chao-Hui Yu
Hui-Ying Wang
Shun Zhang
Yu-Hong Shi
Jiong Chen
author_facet Xin-Jiang Lu
Qiang Chen
Ye-Jing Rong
Guan-Jun Yang
Chang-Hong Li
Ning-Yi Xu
Chao-Hui Yu
Hui-Ying Wang
Shun Zhang
Yu-Hong Shi
Jiong Chen
author_sort Xin-Jiang Lu
title LECT2 drives haematopoietic stem cell expansion and mobilization via regulating the macrophages and osteolineage cells
title_short LECT2 drives haematopoietic stem cell expansion and mobilization via regulating the macrophages and osteolineage cells
title_full LECT2 drives haematopoietic stem cell expansion and mobilization via regulating the macrophages and osteolineage cells
title_fullStr LECT2 drives haematopoietic stem cell expansion and mobilization via regulating the macrophages and osteolineage cells
title_full_unstemmed LECT2 drives haematopoietic stem cell expansion and mobilization via regulating the macrophages and osteolineage cells
title_sort lect2 drives haematopoietic stem cell expansion and mobilization via regulating the macrophages and osteolineage cells
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/5fc69ea1db63499d875bc68599c36908
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AT shunzhang lect2driveshaematopoieticstemcellexpansionandmobilizationviaregulatingthemacrophagesandosteolineagecells
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