LECT2 drives haematopoietic stem cell expansion and mobilization via regulating the macrophages and osteolineage cells

LECT2 drives haematopoietic stem cell expansion and mobilization via regulating the macrophages and osteolineage cells

How extramedullar cytokines regulate hematopoietic stem cell (HSC) homeostasis is unclear. Here, the authors show that the cytokine leukocyte cell-derived chemotaxin 2 regulates HSC expansion and mobilisation via tumour necrosis factor and interaction with CD209a in macrophages.

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Detalles Bibliográficos
Autores principales: Xin-Jiang Lu, Qiang Chen, Ye-Jing Rong, Guan-Jun Yang, Chang-Hong Li, Ning-Yi Xu, Chao-Hui Yu, Hui-Ying Wang, Shun Zhang, Yu-Hong Shi, Jiong Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/5fc69ea1db63499d875bc68599c36908
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