High-fidelity DNA replication in Mycobacterium tuberculosis relies on a trinuclear zinc center

The polymerase and histidinol phosphatase (PHP) domain in the DNA polymerase DnaE1 is essential for mycobacterial high-fidelity DNA replication. Here, the authors determine the DnaE1 crystal structure, which reveals the PHP-exonuclease mechanism that can be exploited for antibiotic development.

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Autores principales:	Soledad Baños-Mateos, Anne-Marie M. van Roon, Ulla F. Lang, Sarah L. Maslen, J. Mark Skehel, Meindert H. Lamers
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5fc944f0ddb6405aa8447da27bcce74f
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spelling	oai:doaj.org-article:5fc944f0ddb6405aa8447da27bcce74f2021-12-02T14:42:39ZHigh-fidelity DNA replication in Mycobacterium tuberculosis relies on a trinuclear zinc center10.1038/s41467-017-00886-w2041-1723https://doaj.org/article/5fc944f0ddb6405aa8447da27bcce74f2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00886-whttps://doaj.org/toc/2041-1723The polymerase and histidinol phosphatase (PHP) domain in the DNA polymerase DnaE1 is essential for mycobacterial high-fidelity DNA replication. Here, the authors determine the DnaE1 crystal structure, which reveals the PHP-exonuclease mechanism that can be exploited for antibiotic development.Soledad Baños-MateosAnne-Marie M. van RoonUlla F. LangSarah L. MaslenJ. Mark SkehelMeindert H. LamersNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Soledad Baños-Mateos Anne-Marie M. van Roon Ulla F. Lang Sarah L. Maslen J. Mark Skehel Meindert H. Lamers High-fidelity DNA replication in Mycobacterium tuberculosis relies on a trinuclear zinc center
description	The polymerase and histidinol phosphatase (PHP) domain in the DNA polymerase DnaE1 is essential for mycobacterial high-fidelity DNA replication. Here, the authors determine the DnaE1 crystal structure, which reveals the PHP-exonuclease mechanism that can be exploited for antibiotic development.
format	article
author	Soledad Baños-Mateos Anne-Marie M. van Roon Ulla F. Lang Sarah L. Maslen J. Mark Skehel Meindert H. Lamers
author_facet	Soledad Baños-Mateos Anne-Marie M. van Roon Ulla F. Lang Sarah L. Maslen J. Mark Skehel Meindert H. Lamers
author_sort	Soledad Baños-Mateos
title	High-fidelity DNA replication in Mycobacterium tuberculosis relies on a trinuclear zinc center
title_short	High-fidelity DNA replication in Mycobacterium tuberculosis relies on a trinuclear zinc center
title_full	High-fidelity DNA replication in Mycobacterium tuberculosis relies on a trinuclear zinc center
title_fullStr	High-fidelity DNA replication in Mycobacterium tuberculosis relies on a trinuclear zinc center
title_full_unstemmed	High-fidelity DNA replication in Mycobacterium tuberculosis relies on a trinuclear zinc center
title_sort	high-fidelity dna replication in mycobacterium tuberculosis relies on a trinuclear zinc center
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5fc944f0ddb6405aa8447da27bcce74f
work_keys_str_mv	AT soledadbanosmateos highfidelitydnareplicationinmycobacteriumtuberculosisreliesonatrinuclearzinccenter AT annemariemvanroon highfidelitydnareplicationinmycobacteriumtuberculosisreliesonatrinuclearzinccenter AT ullaflang highfidelitydnareplicationinmycobacteriumtuberculosisreliesonatrinuclearzinccenter AT sarahlmaslen highfidelitydnareplicationinmycobacteriumtuberculosisreliesonatrinuclearzinccenter AT jmarkskehel highfidelitydnareplicationinmycobacteriumtuberculosisreliesonatrinuclearzinccenter AT meinderthlamers highfidelitydnareplicationinmycobacteriumtuberculosisreliesonatrinuclearzinccenter
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High-fidelity DNA replication in Mycobacterium tuberculosis relies on a trinuclear zinc center

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