High-fidelity DNA replication in Mycobacterium tuberculosis relies on a trinuclear zinc center

High-fidelity DNA replication in Mycobacterium tuberculosis relies on a trinuclear zinc center

The polymerase and histidinol phosphatase (PHP) domain in the DNA polymerase DnaE1 is essential for mycobacterial high-fidelity DNA replication. Here, the authors determine the DnaE1 crystal structure, which reveals the PHP-exonuclease mechanism that can be exploited for antibiotic development.

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Autores principales: Soledad Baños-Mateos, Anne-Marie M. van Roon, Ulla F. Lang, Sarah L. Maslen, J. Mark Skehel, Meindert H. Lamers
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
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Acceso en línea:https://doaj.org/article/5fc944f0ddb6405aa8447da27bcce74f
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